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    nPAP nuclear poly(a) polymerase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829421, updated on 15-Oct-2023

    Summary

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    Gene symbol
    nPAP
    Gene description
    nuclear poly(a) polymerase
    Primary source
    Araport:AT4G32850
    Locus tag
    AT4G32850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    nuclear poly(a) polymerase; PAP(IV); PAPS4; poly(A) polymerase 4; poly(A) polymerase IV
    Summary
    Encodes a nuclear poly(A) polymerase. Located in the nucleus.
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    Genomic context

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    See nPAP in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Sequence:
    Chromosome: 4; NC_003075.7 (15849711..15855194)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene carotenoid cleavage dioxygenase 8 Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ataurora1 Neighboring gene phosphofructokinase 6 Neighboring gene Avr9/Cf-9 rapidly elicited protein Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Target specificity among canonical nuclear poly(A) polymerases in plants modulates organ growth and pathogen response. Vi SL, et al. Proc Natl Acad Sci U S A, 2013 Aug 20. PMID 23918356, Free PMC Article
    2. An interaction between an Arabidopsis poly(A) polymerase and a homologue of the 100 kDa subunit of CPSF. Elliott BJ, et al. Plant Mol Biol, 2003 Feb. PMID 12602868
    3. Characterization of genes encoding poly(A) polymerases in plants: evidence for duplication and functional specialization. Meeks LR, et al. PLoS One, 2009 Nov 26. PMID 19956626, Free PMC Article
    4. Novel alternative splicing of mRNAs encoding poly(A) polymerases in Arabidopsis. Addepalli B, et al. Biochim Biophys Acta, 2004 Aug 12. PMID 15297145
    5. An Arabidopsis Fip1 homolog interacts with RNA and provides conceptual links with a number of other polyadenylation factor subunits. Forbes KP, et al. J Biol Chem, 2006 Jan 6. PMID 16282318

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The relative activities of canonical nuclear PAPS isoforms control de novo synthesized poly(A) tail length and hence expression of specific subsets of mRNAs.
      Title: Target specificity among canonical nuclear poly(A) polymerases in plants modulates organ growth and pathogen response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036701.1
    NM_001036702.1
    NM_001125630.1
    NM_001125631.2
    NM_001342179.1
    NM_001342180.1
    NM_001342181.1
    NM_001342182.1
    NM_001342183.1
    NM_001342184.1
    NM_001342185.1
    NM_119438.4
    NM_179230.2
    NM_179231.2
    NM_202939.3
    NM_202940.3
    NM_202941.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    nuclear poly(a) polymerase
    NP_001031778.1
    • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001031779.1
    • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001119102.1
    • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_001119103.1
    • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_195011.4
    • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 808 Blast hits to 801 proteins in 219 species: Archae - 0; Bacteria - 13; Metazoa - 260; Fungi - 212; Plants - 185; Viruses - 0; Other Eukaryotes - 138 (source: NCBI BLink).
    NP_849561.1
    • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 808 Blast hits to 801 proteins in 219 species: Archae - 0; Bacteria - 13; Metazoa - 260; Fungi - 212; Plants - 185; Viruses - 0; Other Eukaryotes - 138 (source: NCBI BLink).
    NP_849562.2
    • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_974668.1
    • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_974669.1
    • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_974670.2
    • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 808 Blast hits to 801 proteins in 219 species: Archae - 0; Bacteria - 13; Metazoa - 260; Fungi - 212; Plants - 185; Viruses - 0; Other Eukaryotes - 138 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15849711..15855194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202939.3 → NP_974668.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974668.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UV15
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    2. NM_001342180.1 → NP_001329664.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UV15
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    3. NM_001342182.1 → NP_001329669.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UV15
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    4. NM_001342181.1 → NP_001329663.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UV15
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    5. NM_001342179.1 → NP_001329665.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UV15
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    6. NM_001125631.2 → NP_001119103.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119103.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UUT9, A0A7G2F7M2
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    7. NM_202940.3 → NP_974669.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974669.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F2N9
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    8. NM_179230.2 → NP_849561.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849561.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H654, B9DFE4, F4JV63, F4JV67, F4JV69, F4JV71, F4JV72, Q0WLA9, Q7XJ91, Q8VYW1, Q9M075
      UniProtKB/TrEMBL
      A0A7G2F7M2
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    9. NM_202941.3 → NP_974670.2  nuclear poly(a) polymerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974670.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F2N9
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    10. NM_001342183.1 → NP_001329668.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UV15
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    11. NM_001342184.1 → NP_001329667.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UV15
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    12. NM_001342185.1 → NP_001329666.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UV15
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    13. NM_001036702.1 → NP_001031779.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031779.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F7M2
      Conserved Domains (3) summary
      COG5186
      Location:15 → 505
      PAP1; Poly(A) polymerase Pap1 [RNA processing and modification]
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    14. NM_001036701.1 → NP_001031778.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031778.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UV15
      Conserved Domains (3) summary
      COG5186
      Location:15 → 505
      PAP1; Poly(A) polymerase Pap1 [RNA processing and modification]
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    15. NM_179231.2 → NP_849562.2  nuclear poly(a) polymerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849562.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F2N9
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    16. NM_119438.4 → NP_195011.4  nuclear poly(a) polymerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195011.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F2N9
      Conserved Domains (3) summary
      COG5186
      Location:15 → 505
      PAP1; Poly(A) polymerase Pap1 [RNA processing and modification]
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain

    17. NM_001125630.1 → NP_001119102.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119102.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F2N9
      Conserved Domains (2) summary
      pfam04926
      Location:369 → 501
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 365
      PAP_central; Poly(A) polymerase central domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VYW1.1

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