Format

Send to:

Choose Destination
    • Showing Current items.

    CD34 CD34 molecule [ Homo sapiens (human) ]

    Gene ID: 947, updated on 22-May-2016
    Official Symbol
    CD34provided by HGNC
    Official Full Name
    CD34 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1662
    See related
    Ensembl:ENSG00000174059 HPRD:00790; MIM:142230; Vega:OTTHUMG00000036565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
    Orthologs
    Location:
    1q32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (207881028..207911338, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (208059883..208084742, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 132 Neighboring gene uncharacterized LOC148696 Neighboring gene uncharacterized LOC105372882 Neighboring gene uncharacterized LOC105372883 Neighboring gene plexin A2 Neighboring gene uncharacterized LOC105372887

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common variants associated with general and MMR vaccine-related febrile seizures.
    NHGRI GWA Catalog
    Genome-wide association analysis identifies multiple loci related to resting heart rate.
    NHGRI GWA Catalog
    Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
    NHGRI GWA Catalog
    Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sulfate binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell motility IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endothelium development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    extracellular exosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glomerular endothelium development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    glomerular filtration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    hematopoietic stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukocyte migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mesangial cell-matrix adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metanephric glomerular mesangial cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of blood coagulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-2 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    paracrine signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of glial cell-derived neurotrophic factor secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of granulocyte colony-stimulating factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of granulocyte colony-stimulating factor production IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of interleukin-10 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of odontogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transforming growth factor beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of vasculogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    signal transduction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    single organismal cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stem cell proliferation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    tissue homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transdifferentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    vascular wound healing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    basal plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glomerular endothelium fenestra ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intercellular bridge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    hematopoietic progenitor cell antigen CD34
    Names
    CD34 antigen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025109.1NP_001020280.1  hematopoietic progenitor cell antigen CD34 isoform a precursor

      See identical proteins and their annotated locations for NP_001020280.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AA022917, BC039146, M81104
      Consensus CDS
      CCDS31011.1
      UniProtKB/Swiss-Prot
      P28906
      Related
      ENSP00000310036, OTTHUMP00000034733, ENST00000310833, OTTHUMT00000088933
      Conserved Domains (1) summary
      pfam06365
      Location:190385
      CD34_antigen; CD34/Podocalyxin family
    2. NM_001773.2NP_001764.1  hematopoietic progenitor cell antigen CD34 isoform b precursor

      See identical proteins and their annotated locations for NP_001764.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AA022917, AL356275, BC039146, M81104
      Consensus CDS
      CCDS31012.1
      UniProtKB/Swiss-Prot
      P28906
      Related
      ENSP00000348916, OTTHUMP00000034734, ENST00000356522, OTTHUMT00000088934
      Conserved Domains (1) summary
      pfam06365
      Location:190328
      CD34_antigen; CD34/Podocalyxin family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      207881028..207911338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510170.1XP_011508472.1  

      See identical proteins and their annotated locations for XP_011508472.1

      Conserved Domains (1) summary
      pfam06365
      Location:190324
      CD34_antigen; CD34/Podocalyxin family

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      209332232..209357037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)