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    Klf7 Kruppel-like transcription factor 7 (ubiquitous) [ Mus musculus (house mouse) ]

    Gene ID: 93691, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Klf7provided by MGI
    Official Full Name
    Kruppel-like transcription factor 7 (ubiquitous)provided by MGI
    Primary source
    MGI:MGI:1935151
    See related
    Ensembl:ENSMUSG00000025959 AllianceGenome:MGI:1935151
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830124P08Rik
    Summary
    Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within axon guidance; dendrite morphogenesis; and positive regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including genitourinary system; gut; immune system; nervous system; and sensory organ. Orthologous to human KLF7 (Kruppel like factor 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 10.9), whole brain E14.5 (RPKM 9.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C2; 1 32.31 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (64068607..64161504, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (64029448..64122345, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene carboxypeptidase O pseudogene Neighboring gene STARR-seq mESC enhancer starr_01146 Neighboring gene predicted gene 13749 Neighboring gene VISTA enhancer mm997 Neighboring gene STARR-seq mESC enhancer starr_01147 Neighboring gene microRNA 6899 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:64134490-64134740 Neighboring gene STARR-seq mESC enhancer starr_01149 Neighboring gene predicted gene 13748 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:64168151-64168260 Neighboring gene predicted gene, 35880 Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene 1_583.1 Neighboring gene STARR-seq mESC enhancer starr_01150 Neighboring gene STARR-seq mESC enhancer starr_01151 Neighboring gene STARR-seq mESC enhancer starr_01152 Neighboring gene predicted gene, 39654

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KLF7 overexpression in bone marrow stromal stem cells graft transplantation promotes sciatic nerve regeneration. Li WY, et al. J Neural Eng, 2019 Aug 12. PMID 31296795
    2. AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury. Li WY, et al. Neural Plast, 2017. PMID 28884027, Free PMC Article
    3. KLF7 Regulates Satellite Cell Quiescence in Response to Extracellular Signaling. Wang X, et al. Stem Cells, 2016 May. PMID 26930448
    4. Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function. Schuettpelz LG, et al. Blood, 2012 Oct 11. PMID 22936656, Free PMC Article
    5. Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract. Blackmore MG, et al. Proc Natl Acad Sci U S A, 2012 May 8. PMID 22529377, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-520f-3p blocks MNNG-induced gastric precancerous lesions via the KLF7/NFkappaB pathway.
      Title: miR-520f-3p blocks MNNG-induced gastric precancerous lesions via the KLF7/NFκB pathway.
    2. KLF7 promotes adipocyte inflammation and glucose metabolism disorder by activating the PKCzeta/NF-kappaB pathway.
      Title: KLF7 promotes adipocyte inflammation and glucose metabolism disorder by activating the PKCζ/NF-κB pathway.
    3. The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice.
      Title: The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice.
    4. KLF7 Alleviates Atherosclerotic Lesions and Inhibits Glucose Metabolic Reprogramming in Macrophages by Regulating HDAC4/miR-148b-3p/NCOR1.
      Title: KLF7 Alleviates Atherosclerotic Lesions and Inhibits Glucose Metabolic Reprogramming in Macrophages by Regulating HDAC4/miR-148b-3p/NCOR1.
    5. Kruppel-like Transcription Factor 7 Is a Causal Gene in Autism Development.
      Title: Krüppel-like Transcription Factor 7 Is a Causal Gene in Autism Development.
    6. Methylation of miR-19b-3p promoter exacerbates inflammatory responses in sepsis-induced ALI via targeting KLF7.
      Title: Methylation of miR-19b-3p promoter exacerbates inflammatory responses in sepsis-induced ALI via targeting KLF7.
    7. MicroRNA-136-3p inhibits glioma tumorigenesis in vitro and in vivo by targeting KLF7.
      Title: MicroRNA-136-3p inhibits glioma tumorigenesis in vitro and in vivo by targeting KLF7.
    8. KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity.
      Title: KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity.
    9. KLF7 overexpression in bone marrow stromal stem cells graft transplantation promotes sciatic nerve regeneration.
      Title: KLF7 overexpression in bone marrow stromal stem cells graft transplantation promotes sciatic nerve regeneration.
    10. Mechanistically, KLF7 transcriptionally activated argininosuccinate lyase (ASL), which was observed highly expressed in glioma tissues. KLF7 accelerates the xenografted tumor growth of glioma cells. KLF7 potentiates polyamine biosynthesis and glioma cell growth via transcriptionally activates ASL.
      Title: KLF7 promotes polyamine biosynthesis and glioma development through transcriptionally activating ASL.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of epidermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Krueppel-like factor 7
    Names
    Kruppel-like factor 7 (ubiquitous)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033563.2 → NP_291041.2  Krueppel-like factor 7

      See identical proteins and their annotated locations for NP_291041.2

      Status: PROVISIONAL

      Source sequence(s)
      BC019604
      Consensus CDS
      CCDS15003.1
      UniProtKB/Swiss-Prot
      Q99JB0, Q99P62
      UniProtKB/TrEMBL
      Q3UES6
      Related
      ENSMUSP00000109720.3, ENSMUST00000114086.8
      Conserved Domains (5) summary
      COG5048
      Location:211 → 283
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223 → 242
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:278 → 300
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:264 → 289
      zf-H2C2_2; Zinc-finger double domain
      cd21585
      Location:2 → 219
      KLF7_N; N-terminal domain of Kruppel-like factor 7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      64068607..64161504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243769.1 → XP_030099629.1  Krueppel-like factor 7 isoform X2

      UniProtKB/Swiss-Prot
      Q99JB0, Q99P62
      UniProtKB/TrEMBL
      Q3UES6
      Conserved Domains (5) summary
      COG5048
      Location:211 → 283
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223 → 242
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:278 → 300
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:264 → 289
      zf-H2C2_2; Zinc-finger double domain
      cd21585
      Location:2 → 219
      KLF7_N; N-terminal domain of Kruppel-like factor 7

    2. XM_030243770.1 → XP_030099630.1  Krueppel-like factor 7 isoform X2

      UniProtKB/Swiss-Prot
      Q99JB0, Q99P62
      UniProtKB/TrEMBL
      Q3UES6
      Conserved Domains (5) summary
      COG5048
      Location:211 → 283
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223 → 242
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:278 → 300
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:264 → 289
      zf-H2C2_2; Zinc-finger double domain
      cd21585
      Location:2 → 219
      KLF7_N; N-terminal domain of Kruppel-like factor 7

    3. XM_006496352.5 → XP_006496415.1  Krueppel-like factor 7 isoform X1

      See identical proteins and their annotated locations for XP_006496415.1

      UniProtKB/TrEMBL
      Q3UES6
      Conserved Domains (5) summary
      COG5048
      Location:223 → 281
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223 → 242
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:279 → 301
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:265 → 290
      zf-H2C2_2; Zinc-finger double domain
      cd21585
      Location:2 → 219
      KLF7_N; N-terminal domain of Kruppel-like factor 7

    4. XM_006496353.4 → XP_006496416.1  Krueppel-like factor 7 isoform X1

      See identical proteins and their annotated locations for XP_006496416.1

      UniProtKB/TrEMBL
      Q3UES6
      Conserved Domains (5) summary
      COG5048
      Location:223 → 281
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223 → 242
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:279 → 301
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:265 → 290
      zf-H2C2_2; Zinc-finger double domain
      cd21585
      Location:2 → 219
      KLF7_N; N-terminal domain of Kruppel-like factor 7

    5. XM_006496354.4 → XP_006496417.1  Krueppel-like factor 7 isoform X2

      See identical proteins and their annotated locations for XP_006496417.1

      UniProtKB/Swiss-Prot
      Q99JB0, Q99P62
      UniProtKB/TrEMBL
      Q3UES6
      Conserved Domains (5) summary
      COG5048
      Location:211 → 283
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223 → 242
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:278 → 300
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:264 → 289
      zf-H2C2_2; Zinc-finger double domain
      cd21585
      Location:2 → 219
      KLF7_N; N-terminal domain of Kruppel-like factor 7

    6. XM_006496351.4 → XP_006496414.1  Krueppel-like factor 7 isoform X1

      See identical proteins and their annotated locations for XP_006496414.1

      UniProtKB/TrEMBL
      Q3UES6
      Conserved Domains (5) summary
      COG5048
      Location:223 → 281
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223 → 242
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:279 → 301
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:265 → 290
      zf-H2C2_2; Zinc-finger double domain
      cd21585
      Location:2 → 219
      KLF7_N; N-terminal domain of Kruppel-like factor 7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JB0.1 GenPept UniProtKB/Swiss-Prot:Q99JB0

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