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    IPK1 inositol pentakisphosphate 2-kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851910, updated on 13-Apr-2024

    Summary

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    Gene symbol
    IPK1
    Gene description
    inositol pentakisphosphate 2-kinase
    Primary source
    SGD:S000002723
    Locus tag
    YDR315C
    See related
    AllianceGenome:SGD:S000002723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GSL1
    Summary
    Enables inositol pentakisphosphate 2-kinase activity. Involved in inositol phosphate biosynthetic process and nuclear-transcribed mRNA catabolic process, non-stop decay. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1092741..1093586, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase Neighboring gene Rad34p Neighboring gene putative RNA methyltransferase Neighboring gene tRNA-Phe

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential expression of structural genes for the late phase of phytic acid biosynthesis in developing seeds of wheat (Triticum aestivum L.). Bhati KK, et al. Plant Sci, 2014 Jul. PMID 24908508
    2. Molecular and biochemical identification of inositol 1,3,4,5,6-pentakisphosphate 2-kinase encoding mRNA variants in castor bean (Ricinus communis L.) seeds. Yu J, et al. Planta, 2014 May. PMID 24463774
    3. Dual functions for the Schizosaccharomyces pombe inositol kinase Ipk1 in nuclear mRNA export and polarized cell growth. Sarmah B, et al. Eukaryot Cell, 2009 Feb. PMID 19047361, Free PMC Article
    4. Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1). Sweetman D, et al. Biochem J, 2006 Feb 15. PMID 16223361, Free PMC Article
    5. Structure of the C-terminus of the mRNA export factor Dbp5 reveals the interaction surface for the ATPase activator Gle1. Dossani ZY, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805289, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol pentakisphosphate 2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol pentakisphosphate 2-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol pentakisphosphate 2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol pentakisphosphate 2-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in inositol phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, non-stop decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inositol pentakisphosphate 2-kinase
    NP_010601.3
    • Inositol 1,3,4,5,6-pentakisphosphate 2-kinase; nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable; human IPPK can complement ipk1 null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1092741..1093586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180623.3 → NP_010601.3  TPA: inositol pentakisphosphate 2-kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010601.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSU4, Q06667
      UniProtKB/TrEMBL
      A0A8H8UNL4, A6ZYR3, C7GWL2, C8Z5M6, N1P8M0
      Conserved Domains (1) summary
      pfam06090
      Location:4 → 265
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06667.1

    Gene LinkOut

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