CDC13 telomere-binding protein CDC13 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: CDC13
Gene description: telomere-binding protein CDC13
Primary source: SGD:S000002379
Locus tag: YDL220C
See related: AllianceGenome:SGD:S000002379
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: EST4
Summary: Enables single-stranded telomeric DNA binding activity; telomerase inhibitor activity; and translation elongation factor binding activity. Involved in regulation of DNA biosynthetic process; ribonucleoprotein complex localization; and telomere maintenance. Located in chromosome, telomeric region. Part of CST complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (62244..65018, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pif1 Helicase Mediates Remodeling of Protein-Nucleic Acid Complexes by Promoting Dissociation of Sub1 from G-Quadruplex DNA and Cdc13 from G-Rich Single-Stranded DNA.
Title: Pif1 Helicase Mediates Remodeling of Protein-Nucleic Acid Complexes by Promoting Dissociation of Sub1 from G-Quadruplex DNA and Cdc13 from G-Rich Single-Stranded DNA.
Deletion of MEC1 suppresses the replicative senescence of the cdc13-2 mutant in Saccharomyces cerevisiae.
Title: Deletion of MEC1 suppresses the replicative senescence of the cdc13-2 mutant in Saccharomyces cerevisiae.
Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast.
Title: Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast.
Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions.
Title: Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions.
Loss of Cdc13 causes deficiency in replication-dependent telomere capping and leads to genome instability.
Title: Loss of Cdc13 causes genome instability by a deficiency in replication-dependent telomere capping.
Ten1, Cdc13 and Stn1, were found to physically associate with Spt5. This study proposes that Spt5 represents the target of the Cdc13-Stn1-Ten1 complex in transcription regulation.
Title: The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription.
Data show that telomere-binding protein CDC13 (Cdc13) homodimerization occurs even if the protein is not bound to DNA and is in the cytoplasm.
Title: Nuclear import of Cdc13 limits chromosomal capping.
Studies chow that subcellular localisation of telomere-binding protein CDC13 (Cdc13) is critically important [Review].
Title: Fine tuning the level of the Cdc13 telomere-capping protein for maximal chromosome stability performance.
The N-terminal interface of Cdc13-Est1 backstops TLC1-Ku-Sir4 to recruit telomerase. The C-terminal interface of Cdc13-Est1 is crucial for telomere maintenance in vivo.
Title: Structural Insights into Yeast Telomerase Recruitment to Telomeres.
DNA binding by Cdc13 employs a highly cooperative interface whereby sequence diversity is accommodated through plastic binding modes.
Title: Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables G-rich strand telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded telomeric DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded telomeric DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables telomerase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables telomerase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation elongation factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomerase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of telomere maintenance via telomerase	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of telomere maintenance via telomerase	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of telomere maintenance via telomerase	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribonucleoprotein complex localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance via telomerase	IGI Inferred from Genetic Interaction more info	PubMed
involved_in telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CST complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in intracellular organelle	IEA Inferred from Electronic Annotation more info
part_of nuclear telomere cap complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: telomere-binding protein CDC13

NP_010061.1

Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles in regulation of telomerase, telomere end protection, conventional telomere replication; regulates telomere replication through recruitment of specific sub-complexes, essential function is telomere capping; forms homodimer via N-terminus; disruption of dimerization leads to short telomeres; autophagy and proteasome are involved in Cdc13p degradation; differentially phosphorylated through cell cycle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

62244..65018 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180280.1 → NP_010061.1 TPA: telomere-binding protein CDC13 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010061.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRD4, P32797, Q07650

UniProtKB/TrEMBL

A0A8H8UM82, G2WBU7, N1P4F9

Conserved Domains (4) summary

smart00976
Location:510 → 665

Telo_bind; Telomeric single stranded DNA binding POT1/CDC13

pfam16853
Location:14 → 241

CDC13_N; Cell division control protein 13 N-terminus

pfam18233
Location:749 → 871

Cdc13_OB4_dimer; Cdc13 OB4 dimerization domain

pfam18691
Location:359 → 471

Cdc13_OB2; Cell division control protein 13, OB2 domain