AT2G26230 uricase / urate oxidase / nodulin 35 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: AT2G26230
Gene description: uricase / urate oxidase / nodulin 35
Primary source: Araport:AT2G26230
Locus tag: AT2G26230
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: T1D16.13; T1D16_13; UOX; urate oxidase
Summary: Encodes a urate oxidase that is involved in peroxisome maintenance.
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Genomic context

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Location:: chromosome: 2

Exon count:: 9

Sequence:: Chromosome: 2; NC_003071.7 (11164575..11167346)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The peroxisomal defect explains the developmental phenotypes of the uox mutant, drawing a novel link between uric acid and peroxisome function, which may be relevant beyond plants.
Title: Uric acid accumulation in an Arabidopsis urate oxidase mutant impairs seedling establishment by blocking peroxisome maintenance.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_128180.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables urate oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urate catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in peroxisome	HDA more info	PubMed

General protein information

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Preferred Names: uricase / urate oxidase / nodulin 35

NP_180191.1

uricase / urate oxidase / nodulin 35, putative; FUNCTIONS IN: urate oxidase activity, oxidoreductase activity; INVOLVED IN: oxidation reduction, purine base metabolic process; LOCATED IN: peroxisome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Uricase, conserved site (InterPro:IPR019842), Uricase (InterPro:IPR002042); Has 677 Blast hits to 673 proteins in 262 species: Archae - 5; Bacteria - 239; Metazoa - 140; Fungi - 185; Plants - 90; Viruses - 0; Other Eukaryotes - 18 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

11164575..11167346

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128180.5 → NP_180191.1 uricase / urate oxidase / nodulin 35 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180191.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O04420, O64848, Q94A71

UniProtKB/TrEMBL

A0A178VYS6

Conserved Domains (2) summary

PLN02415
Location:4 → 309

PLN02415; uricase

cd00445
Location:13 → 304

Uricase; Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the ...