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    FBXL15 F-box and leucine rich repeat protein 15 [ Homo sapiens (human) ]

    Gene ID: 79176, updated on 5-Mar-2024

    Summary

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    Official Symbol
    FBXL15provided by HGNC
    Official Full Name
    F-box and leucine rich repeat protein 15provided by HGNC
    Primary source
    HGNC:HGNC:28155
    See related
    Ensembl:ENSG00000107872 MIM:610287; AllianceGenome:HGNC:28155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JET; PSD; Fbl15; FBXO37
    Summary
    Involved in G2/M transition of mitotic cell cycle; cellular protein metabolic process; and positive regulation of BMP signaling pathway. Located in cytoplasm. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney (RPKM 4.8), colon (RPKM 3.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10q24.32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (102420836..102423136)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103304934..103308100)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104180593..104182893)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3929 Neighboring gene Sharpr-MPRA regulatory region 13585 Neighboring gene nuclear factor kappa B subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104160632-104161328 Neighboring gene Sharpr-MPRA regulatory region 3575 Neighboring gene pleckstrin and Sec7 domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104169870-104170552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104170553-104171234 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3934 Neighboring gene CUE domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3935 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104192697-104193332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104193333-104193966 Neighboring gene microRNA 146b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A cell based screening approach for identifying protein degradation regulators. Simanski S, et al. Cell Cycle, 2017 May 19. PMID 28296622, Free PMC Article
    2. Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2. Choi J, et al. Nat Cell Biol, 2018 May. PMID 29695787, Free PMC Article
    3. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Busino L, et al. Science, 2007 May 11. PMID 17463251
    4. FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells. Saffie R, et al. Cancer Res, 2020 Jun 15. PMID 32350066, Free PMC Article
    5. The ULK1-FBXW5-SEC23B nexus controls autophagy. Jeong YT, et al. Elife, 2018 Dec 31. PMID 30596474, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16137, MGC11279

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dorsal/ventral pattern formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 15
    Names
    F-box only protein 37
    pleckstrin and Sec7 domain protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001387294.1 → NP_001374223.1  F-box/LRR-repeat protein 15

      Status: VALIDATED

      Source sequence(s)
      AL121928
      Consensus CDS
      CCDS31273.1
      UniProtKB/Swiss-Prot
      A1L4J8, B1AKX8, B1AKX9, B1AKY0, B1AKY1, C9JWA4, Q0D2Q3, Q49AL7, Q5JWA5, Q9H469
      UniProtKB/TrEMBL
      A0A0C4DFV0
      Conserved Domains (3) summary
      cd09293
      Location:139 → 266
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:62 → 88
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00646
      Location:18 → 55
      F-box; F-box domain

    2. NM_024326.4 → NP_077302.3  F-box/LRR-repeat protein 15

      See identical proteins and their annotated locations for NP_077302.3

      Status: VALIDATED

      Source sequence(s)
      AL121928
      Consensus CDS
      CCDS31273.1
      UniProtKB/Swiss-Prot
      A1L4J8, B1AKX8, B1AKX9, B1AKY0, B1AKY1, C9JWA4, Q0D2Q3, Q49AL7, Q5JWA5, Q9H469
      UniProtKB/TrEMBL
      A0A0C4DFV0
      Related
      ENSP00000358972.3, ENST00000369956.8
      Conserved Domains (3) summary
      cd09293
      Location:139 → 266
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:62 → 88
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00646
      Location:18 → 55
      F-box; F-box domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      102420836..102423136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      103304934..103308100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366712.1 → XP_054222687.1  F-box/LRR-repeat protein 15 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H469.2 GenPept UniProtKB/Swiss-Prot:Q9H469

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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