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    Ift46 intraflagellar transport 46 [ Mus musculus (house mouse) ]

    Gene ID: 76568, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ift46provided by MGI
    Official Full Name
    intraflagellar transport 46provided by MGI
    Primary source
    MGI:MGI:1923818
    See related
    Ensembl:ENSMUSG00000002031 AllianceGenome:MGI:1923818
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    c11orf2; 1500035H01Rik
    Summary
    Acts upstream of or within cilium assembly and smoothened signaling pathway. Located in centrosome and motile cilium. Part of intraciliary transport particle B. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; hindlimb; and otocyst. Orthologous to human IFT46 (intraflagellar transport 46). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 16.0), CNS E14 (RPKM 11.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44683074..44704011)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44770456..44792714)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology like domain, family B, member 1 Neighboring gene predicted gene, 24166 Neighboring gene archain 1 Neighboring gene STARR-positive B cell enhancer ABC_E9756 Neighboring gene transmembrane protein 25 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene lysine (K)-specific methyltransferase 2A Neighboring gene predicted gene, 39326 Neighboring gene STARR-positive B cell enhancer ABC_E6728

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery. Ahmed NT, et al. J Cell Biol, 2008 Oct 20. PMID 18852297, Free PMC Article
    2. Autophagy induction promotes renal cyst growth in polycystic kidney disease. Lee EJ, et al. EBioMedicine, 2020 Oct. PMID 32949996, Free PMC Article
    3. A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling. Swiderski RE, et al. PLoS Genet, 2014 Oct. PMID 25340710, Free PMC Article
    4. IFT46 plays an essential role in cilia development. Lee MS, et al. Dev Biol, 2015 Apr 15. PMID 25722189, Free PMC Article
    5. Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish. Gouttenoire J, et al. J Biol Chem, 2007 Oct 19. PMID 17720815

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the ciliary protein IFT46 has a specific function in chondrocytes and is also essential for normal development of vertebrates.
      Title: Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium organization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium-dependent cell motility ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in intraciliary anterograde transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intraciliary transport IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary base ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cilium TAS
    Traceable Author Statement
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of intraciliary transport particle B ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    intraflagellar transport protein 46 homolog
    Names
    intraflagellar transport 46 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023831.3 → NP_076320.2  intraflagellar transport protein 46 homolog

      See identical proteins and their annotated locations for NP_076320.2

      Status: PROVISIONAL

      Source sequence(s)
      AK032880
      Consensus CDS
      CCDS23119.1
      UniProtKB/Swiss-Prot
      Q91Z06, Q9DB07, Q9JHT1
      UniProtKB/TrEMBL
      A0A5F8MPR6
      Related
      ENSMUSP00000159011.2, ENSMUST00000239014.2
      Conserved Domains (1) summary
      pfam12317
      Location:62 → 264
      IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44683074..44704011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510671.5 → XP_006510734.1  intraflagellar transport protein 46 homolog isoform X1

      See identical proteins and their annotated locations for XP_006510734.1

      UniProtKB/Swiss-Prot
      Q91Z06, Q9DB07, Q9JHT1
      UniProtKB/TrEMBL
      A0A5F8MPR6
      Conserved Domains (1) summary
      pfam12317
      Location:62 → 264
      IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

    2. XM_006510672.5 → XP_006510735.1  intraflagellar transport protein 46 homolog isoform X2

      UniProtKB/TrEMBL
      A0A1L1SR19
      Related
      ENSMUSP00000149271.3, ENSMUST00000214854.3
      Conserved Domains (1) summary
      pfam12317
      Location:62 → 222
      IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

    3. XM_036155404.1 → XP_036011297.1  intraflagellar transport protein 46 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q91Z06, Q9DB07, Q9JHT1
      UniProtKB/TrEMBL
      A0A5F8MPR6
      Related
      ENSMUSP00000113845.2, ENSMUST00000118186.2
      Conserved Domains (1) summary
      pfam12317
      Location:62 → 264
      IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

    RNA

    1. XR_001779069.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB07.1 GenPept UniProtKB/Swiss-Prot:Q9DB07

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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