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    Glt8d1 glycosyltransferase 8 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 76485, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Glt8d1provided by MGI
    Official Full Name
    glycosyltransferase 8 domain containing 1provided by MGI
    Primary source
    MGI:MGI:1923735
    See related
    Ensembl:ENSMUSG00000021916 AllianceGenome:MGI:1923735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410004H05Rik; 5430414N14Rik
    Summary
    This gene encodes a member of the glycosyltransferase family. The encoded protein is a type II transmembrane protein containing a glycosyltransferase 8 domain in the lumenal (C-terminal) portion. The specific function of this protein has not been determined. Two alternatively spliced variants encoding the same isoform have been described. [provided by RefSeq, Sep 2009]
    Expression
    Broad expression in testis adult (RPKM 75.2), limb E14.5 (RPKM 20.1) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 B; 14 19.09 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30723137..30733948)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31001197..31012441)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3106 Neighboring gene predicted gene, 41121 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 4 Neighboring gene STARR-seq mESC enhancer starr_36312 Neighboring gene signal peptidase complex subunit 1 homolog (S. cerevisiae) Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene predicted gene, 24916 Neighboring gene guanine nucleotide binding protein nucleolar 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes. Yang CP, et al. Nat Commun, 2018 Feb 26. PMID 29483533, Free PMC Article
    2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycosyltransferase 8 domain-containing protein 1
    NP_001159402.1
    NP_001390227.1
    NP_001390228.1
    NP_001390229.1
    NP_001390230.1
    NP_001390234.1
    NP_001390235.1
    NP_001390237.1
    NP_001390239.1
    NP_001390265.1
    NP_001390266.1
    NP_001390267.1
    NP_001390268.1
    NP_001390269.1
    NP_001390270.1
    NP_001390271.1
    NP_001390272.1
    NP_001390273.1
    NP_001390274.1
    NP_083902.2
    XP_036014787.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165930.2 → NP_001159402.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001159402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154727
      Consensus CDS
      CCDS26904.1
      UniProtKB/Swiss-Prot
      Q3TV18, Q6NSU3, Q9CWT8
      Related
      ENSMUSP00000129323.2, ENSMUST00000168584.9
      Conserved Domains (1) summary
      cd06429
      Location:66 → 351
      GT8_like_1; GT8_like_1 represents a subfamily of GT8 with unknown function

    2. NM_001403298.1 → NP_001390227.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154727
      UniProtKB/Swiss-Prot
      Q3TV18, Q6NSU3, Q9CWT8

    3. NM_001403299.1 → NP_001390228.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154727
      UniProtKB/Swiss-Prot
      Q3TV18, Q6NSU3, Q9CWT8

    4. NM_001403300.1 → NP_001390229.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154727
      UniProtKB/Swiss-Prot
      Q3TV18, Q6NSU3, Q9CWT8

    5. NM_001403301.1 → NP_001390230.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154727
      UniProtKB/Swiss-Prot
      Q3TV18, Q6NSU3, Q9CWT8

    6. NM_001403305.1 → NP_001390234.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154727
      UniProtKB/Swiss-Prot
      Q3TV18, Q6NSU3, Q9CWT8

    7. NM_001403306.1 → NP_001390235.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154727
      UniProtKB/Swiss-Prot
      Q3TV18, Q6NSU3, Q9CWT8

    8. NM_001403308.1 → NP_001390237.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154727
      UniProtKB/Swiss-Prot
      Q3TV18, Q6NSU3, Q9CWT8

    9. NM_001403310.1 → NP_001390239.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154727
      UniProtKB/Swiss-Prot
      Q3TV18, Q6NSU3, Q9CWT8

    10. NM_001403336.1 → NP_001390265.1  glycosyltransferase 8 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154727

    11. NM_001403337.1 → NP_001390266.1  glycosyltransferase 8 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154727
      Related
      ENSMUST00000228255.2

    12. NM_001403338.1 → NP_001390267.1  glycosyltransferase 8 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154727

    13. NM_001403339.1 → NP_001390268.1  glycosyltransferase 8 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154727

    14. NM_001403340.1 → NP_001390269.1  glycosyltransferase 8 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154727

    15. NM_001403341.1 → NP_001390270.1  glycosyltransferase 8 domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154727

    16. NM_001403342.1 → NP_001390271.1  glycosyltransferase 8 domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154727

    17. NM_001403343.1 → NP_001390272.1  glycosyltransferase 8 domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154727

    18. NM_001403344.1 → NP_001390273.1  glycosyltransferase 8 domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154727

    19. NM_001403345.1 → NP_001390274.1  glycosyltransferase 8 domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154727

    20. NM_029626.3 → NP_083902.2  glycosyltransferase 8 domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_083902.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154727
      Consensus CDS
      CCDS26904.1
      UniProtKB/Swiss-Prot
      Q3TV18, Q6NSU3, Q9CWT8
      Related
      ENSMUSP00000022476.8, ENSMUST00000022476.9
      Conserved Domains (1) summary
      cd06429
      Location:66 → 351
      GT8_like_1; GT8_like_1 represents a subfamily of GT8 with unknown function

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      30723137..30733948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158894.1 → XP_036014787.1  glycosyltransferase 8 domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      cd06429
      Location:316 → 601
      GT8_like_1; GT8_like_1 represents a subfamily of GT8 with unknown function
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NSU3.1 GenPept UniProtKB/Swiss-Prot:Q6NSU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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