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    Crot carnitine O-octanoyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 74114, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Crotprovided by MGI
    Official Full Name
    carnitine O-octanoyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1921364
    See related
    Ensembl:ENSMUSG00000003623 AllianceGenome:MGI:1921364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200003H03Rik
    Summary
    Enables carnitine O-octanoyltransferase activity. Involved in carnitine metabolic process; coenzyme A metabolic process; and fatty acid metabolic process. Acts upstream of or within fatty acid transport. Located in peroxisome. Is expressed in several structures, including brain; ganglia; gut; liver; and spleen. Orthologous to human CROT (carnitine O-octanoyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 39.3), liver E18 (RPKM 15.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Crot in Genome Data Viewer
    Location:
    5 A1; 5 3.5 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (9016033..9047926, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8966033..8997146, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B member 4 Neighboring gene STARR-seq mESC enhancer starr_12399 Neighboring gene calponin 3, acidic pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6299 Neighboring gene predicted gene, 31388 Neighboring gene STARR-seq mESC enhancer starr_12400 Neighboring gene coiled-coil domain-containing protein 72 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr5:8997064-8997365 Neighboring gene STARR-seq mESC enhancer starr_12401 Neighboring gene STARR-seq mESC enhancer starr_12402 Neighboring gene STARR-seq mESC enhancer starr_12403 Neighboring gene predicted gene, 40264 Neighboring gene STARR-seq mESC enhancer starr_12404 Neighboring gene STARR-seq mESC enhancer starr_12405 Neighboring gene STARR-seq mESC enhancer starr_12406 Neighboring gene transmembrane protein 243, mitochondrial Neighboring gene cyclin D binding myb like transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Regulators of Peroxisomal Acyl-Carnitine Shuttle CROT and CRAT Promote Metastasis in Melanoma. Lasheras-Otero I, et al. J Invest Dermatol, 2023 Feb. PMID 36058299
    2. Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. Jogl G, et al. J Biol Chem, 2005 Jan 7. PMID 15492013
    3. Localization of an exonic splicing enhancer responsible for mammalian natural trans-splicing. Caudevilla C, et al. Nucleic Acids Res, 2001 Jul 15. PMID 11452036, Free PMC Article
    4. Properties of purified carnitine acyltransferases of mouse liver peroxisomes. Farrell SO, et al. J Biol Chem, 1984 Nov 10. PMID 6436243
    5. CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction. Okui T, et al. Arterioscler Thromb Vasc Biol, 2021 Feb. PMID 33356393, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Regulators of Peroxisomal Acyl-Carnitine Shuttle CROT and CRAT Promote Metastasis in Melanoma.
      Title: The Regulators of Peroxisomal Acyl-Carnitine Shuttle CROT and CRAT Promote Metastasis in Melanoma.
    2. CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.
      Title: CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.
    3. the crystal structures of carnitine octanoyltransferase alone and in complex with the substrate octanoylcarnitine
      Title: Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-octanoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnitine O-octanoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carnitine O-octanoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carnitine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in coenzyme A metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fatty acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in generation of precursor metabolites and energy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in medium-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal carnitine O-octanoyltransferase
    Names
    COT
    NP_001404759.1
    NP_001404760.1
    NP_001404761.1
    NP_001404762.1
    NP_076222.1
    XP_006503673.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417830.1 → NP_001404759.1  peroxisomal carnitine O-octanoyltransferase isoform a

      Status: VALIDATED

      Source sequence(s)
      AC107763
      UniProtKB/Swiss-Prot
      Q921I4, Q9DC50

    2. NM_001417831.1 → NP_001404760.1  peroxisomal carnitine O-octanoyltransferase isoform a

      Status: VALIDATED

      Source sequence(s)
      AC107763
      UniProtKB/Swiss-Prot
      Q921I4, Q9DC50

    3. NM_001417832.1 → NP_001404761.1  peroxisomal carnitine O-octanoyltransferase isoform a

      Status: VALIDATED

      Source sequence(s)
      AC107763
      UniProtKB/Swiss-Prot
      Q921I4, Q9DC50

    4. NM_001417833.1 → NP_001404762.1  peroxisomal carnitine O-octanoyltransferase isoform b

      Status: VALIDATED

      Source sequence(s)
      AC107763

    5. NM_023733.3 → NP_076222.1  peroxisomal carnitine O-octanoyltransferase isoform a

      See identical proteins and their annotated locations for NP_076222.1

      Status: VALIDATED

      Source sequence(s)
      AK004567
      Consensus CDS
      CCDS19087.1
      UniProtKB/Swiss-Prot
      Q921I4, Q9DC50
      Related
      ENSMUSP00000003720.5, ENSMUST00000003720.5
      Conserved Domains (1) summary
      pfam00755
      Location:20 → 603
      Carn_acyltransf; Choline/Carnitine o-acyltransferase

    RNA

    1. NR_184637.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      9016033..9047926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503610.4 → XP_006503673.1  peroxisomal carnitine O-octanoyltransferase isoform X2

      Conserved Domains (1) summary
      pfam00755
      Location:152 → 531
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DC50.1 GenPept UniProtKB/Swiss-Prot:Q9DC50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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