Usp36 ubiquitin specific peptidase 36 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp36provided by MGI
Official Full Name: ubiquitin specific peptidase 36provided by MGI
Primary source: MGI:MGI:1919594
See related: Ensembl:ENSMUSG00000033909 AllianceGenome:MGI:1919594
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1453; 2700002L06Rik
Summary: Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Involved in several processes, including protein deubiquitination; protein stabilization; and regulation of rRNA processing. Predicted to be located in cytoplasm; nuclear speck; and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to human USP36 (ubiquitin specific peptidase 36). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 8.8), limb E14.5 (RPKM 8.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 83.06 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (118150477..118181086, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (118259651..118290260, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Usp36 is essential for cell and organism viability because of its role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, by regulating DHX33 stability.
Title: Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice.
USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.
Title: Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K48-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables histone H2B deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in nucleolus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein deubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of rRNA processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 36

Names: deubiquitinating enzyme 36; ubiquitin specific protease 36; ubiquitin thioesterase 36; ubiquitin-specific-processing protease 36

NP_001028700.1

EC 3.4.19.12

XP_006534365.1

EC 3.4.19.12

XP_006534366.1

EC 3.4.19.12

XP_006534367.1

EC 3.4.19.12

XP_011247575.1

EC 3.4.19.12

XP_036012905.1

EC 3.4.19.12

XP_036012906.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033528.1 → NP_001028700.1 ubiquitin carboxyl-terminal hydrolase 36

See identical proteins and their annotated locations for NP_001028700.1

Status: VALIDATED

Source sequence(s)

AL591404

Consensus CDS

CCDS48998.1

UniProtKB/Swiss-Prot

B1AQJ2, Q6ZPQ7

UniProtKB/TrEMBL

B0QZF8

Related

ENSMUSP00000090036.4, ENSMUST00000092382.10

Conserved Domains (2) summary

PHA03247
Location:479 → 989

PHA03247; large tegument protein UL36; Provisional

cd02661
Location:121 → 421

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

118150477..118181086 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534303.2 → XP_006534366.1 ubiquitin carboxyl-terminal hydrolase 36 isoform X1

See identical proteins and their annotated locations for XP_006534366.1

UniProtKB/Swiss-Prot

B1AQJ2, Q6ZPQ7

UniProtKB/TrEMBL

B0QZF8

Conserved Domains (2) summary

PHA03247
Location:479 → 989

PHA03247; large tegument protein UL36; Provisional

cd02661
Location:121 → 421

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_006534304.5 → XP_006534367.1 ubiquitin carboxyl-terminal hydrolase 36 isoform X1

See identical proteins and their annotated locations for XP_006534367.1

UniProtKB/Swiss-Prot

B1AQJ2, Q6ZPQ7

UniProtKB/TrEMBL

B0QZF8

Conserved Domains (2) summary

PHA03247
Location:479 → 989

PHA03247; large tegument protein UL36; Provisional

cd02661
Location:121 → 421

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_036157013.1 → XP_036012906.1 ubiquitin carboxyl-terminal hydrolase 36 isoform X2

Conserved Domains (2) summary

PHA03247
Location:508 → 1018

PHA03247; large tegument protein UL36; Provisional

cd02661
Location:150 → 450

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_036157012.1 → XP_036012905.1 ubiquitin carboxyl-terminal hydrolase 36 isoform X1

UniProtKB/Swiss-Prot

B1AQJ2, Q6ZPQ7

UniProtKB/TrEMBL

B0QZF8

Conserved Domains (2) summary

PHA03247
Location:479 → 989

PHA03247; large tegument protein UL36; Provisional

cd02661
Location:121 → 421

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_011249273.2 → XP_011247575.1 ubiquitin carboxyl-terminal hydrolase 36 isoform X3

Conserved Domains (1) summary

PHA03247
Location:6 → 516

PHA03247; large tegument protein UL36; Provisional
XM_006534302.5 → XP_006534365.1 ubiquitin carboxyl-terminal hydrolase 36 isoform X1

See identical proteins and their annotated locations for XP_006534365.1

UniProtKB/Swiss-Prot

B1AQJ2, Q6ZPQ7

UniProtKB/TrEMBL

B0QZF8

Related

ENSMUSP00000101903.3, ENSMUST00000106296.9

Conserved Domains (2) summary

PHA03247
Location:479 → 989

PHA03247; large tegument protein UL36; Provisional

cd02661
Location:121 → 421

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...