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    Zftraf1 zinc finger TRAF type containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 54151, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zftraf1provided by MGI
    Official Full Name
    zinc finger TRAF type containing 1provided by MGI
    Primary source
    MGI:MGI:1859320
    See related
    Ensembl:ENSMUSG00000053929 AllianceGenome:MGI:1859320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chrp; Cyhr1; 1110031M01Rik
    Summary
    Predicted to enable zinc ion binding activity. Located in cytoplasm and nuclear envelope. Orthologous to human CYHR1 (cysteine and histidine rich 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 18.7), ovary adult (RPKM 16.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D3; 15 36.2 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76527586..76541120, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76643395..76660208, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 28 Neighboring gene tonsoku-like, DNA repair protein Neighboring gene STARR-positive B cell enhancer ABC_E1481 Neighboring gene predicted gene, 57852 Neighboring gene STARR-positive B cell enhancer ABC_E760 Neighboring gene STARR-positive B cell enhancer ABC_E9419 Neighboring gene STARR-positive B cell enhancer ABC_E3145 Neighboring gene transmembrane protein 276 Neighboring gene kinesin family member C2 Neighboring gene forkhead box H1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3. Savarese A, et al. Psychoneuroendocrinology, 2018 Jun. PMID 29609111, Free PMC Article
    2. Interaction of a novel cysteine and histidine-rich cytoplasmic protein with galectin-3 in a carbohydrate-independent manner. Menon RP, et al. FEBS Lett, 2000 Mar 31. PMID 10745073
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough Gm57852

    Readthrough gene: Gm57852, Included gene: Tmem276

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger TRAF-type-containing protein 1
    Names
    Zinc finger TRAF-type-containing protein 1
    cysteine and histidine rich 1
    cysteine and histidine-rich cytoplasmic protein
    cysteine and histidine-rich protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276321.2 → NP_001263250.1  zinc finger TRAF-type-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156550
      Consensus CDS
      CCDS70643.1
      UniProtKB/TrEMBL
      H3BIV6
      Related
      ENSMUSP00000134739.2, ENSMUST00000176274.2
      Conserved Domains (1) summary
      cl19105
      Location:161 → 222
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...

    2. NM_001357882.2 → NP_001344811.1  zinc finger TRAF-type-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156550
      UniProtKB/Swiss-Prot
      H3BIV6, P0DW87
      Conserved Domains (2) summary
      cd16505
      Location:103 → 151
      RING-HC_CYHR1; RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
      cl19105
      Location:161 → 222
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...

    3. NM_001408103.1 → NP_001395032.1  zinc finger TRAF-type-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC156550

    4. NM_001408104.1 → NP_001395033.1  zinc finger TRAF-type-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC156550

    5. NM_001408207.1 → NP_001395136.1  zinc finger TRAF-type-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC156550

    6. NM_001408208.1 → NP_001395137.1  zinc finger TRAF-type-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC156550

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76527586..76541120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DW87.1 GenPept UniProtKB/Swiss-Prot:P0DW87

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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