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    Nmdmc NAD-dependent methylenetetrahydrofolate dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47895, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Nmdmcprovided by FlyBase
    Official Full Name
    NAD-dependent methylenetetrahydrofolate dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010222
    Locus tag
    Dmel_CG18466
    See related
    AllianceGenome:FB:FBgn0010222
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    151767_at; CG18466; Dmdmc; Dmel\CG18466; dNMDMC; Dnmdmc; DNMDMC; Mthfd2; nmdmc
    Summary
    Predicted to enable several functions, including magnesium ion binding activity; methenyltetrahydrofolate cyclohydrolase activity; and methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to be active in mitochondrion. Is expressed in adult head; amnioserosa; embryonic rectum; rectum primordium; and yolk nucleus. Orthologous to human MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like) and MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    85C3-85C3; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9042508..9050555, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4868230..4876277, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR31429 Neighboring gene neuralized Neighboring gene hyrax Neighboring gene Relish Neighboring gene Mst85C Neighboring gene Lysine demethylase 2 Neighboring gene beag Neighboring gene Adenosine deaminase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is targeted to the cytoplasm in insect cell lines. Tremblay GB, et al. FEBS Lett, 1995 Jul 10. PMID 7615077
    2. The Drosophila neuralized gene encodes a C3HC4 zinc finger. Price BD, et al. EMBO J, 1993 Jun. PMID 8508767, Free PMC Article
    3. Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin. Garrido-Maraver J, et al. Cell Death Dis, 2019 Mar 25. PMID 30911005, Free PMC Article
    4. Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species. Yu S, et al. Biochem Biophys Res Commun, 2015 Oct 2. PMID 26319556
    5. The isolation and characterization of a Drosophila gene encoding a putative NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase. Price BD, et al. Biochim Biophys Acta, 1993 Apr 29. PMID 8485162

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables methenyltetrahydrofolate cyclohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methenyltetrahydrofolate cyclohydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methylenetetrahydrofolate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylenetetrahydrofolate dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphate ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrofolate interconversion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrahydrofolate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NAD-dependent methylenetetrahydrofolate dehydrogenase
    Names
    CG18466-PA
    CG18466-PB
    CG18466-PC
    NAD dependent methylenetetrahydrofolate dehydrogenase
    Nmdmc-PA
    Nmdmc-PB
    Nmdmc-PC
    NP_001262398.1
    NP_476929.1
    NP_476930.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9042508..9050555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057581.5 → NP_476929.1  NAD-dependent methylenetetrahydrofolate dehydrogenase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476929.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q04448, Q7KSU1, Q9U6H6, Q9V3H4
      Related
      FBpp0081476
      Conserved Domains (3) summary
      COG0190
      Location:9 → 304
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:10 → 126
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      pfam02882
      Location:129 → 303
      THF_DHG_CYH_C; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

    2. NM_057582.5 → NP_476930.1  NAD-dependent methylenetetrahydrofolate dehydrogenase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476930.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFE5
      Related
      FBpp0081477
      Conserved Domains (3) summary
      COG0190
      Location:3 → 298
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:4 → 120
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      pfam02882
      Location:123 → 297
      THF_DHG_CYH_C; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

    3. NM_001275469.1 → NP_001262398.1  NAD-dependent methylenetetrahydrofolate dehydrogenase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262398.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFE5
      Conserved Domains (3) summary
      COG0190
      Location:3 → 298
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:4 → 120
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      pfam02882
      Location:123 → 297
      THF_DHG_CYH_C; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFE5 A0A0B4KFE5
    Q04448.2 Q04448

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