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    ADCY5 adenylate cyclase 5 [ Canis lupus familiaris (dog) ]

    Gene ID: 403859, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ADCY5provided by VGNC
    Official Full Name
    adenylate cyclase 5provided by VGNC
    Primary source
    VGNC:VGNC:37622
    See related
    Ensembl:ENSCAFG00845024171
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 33
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 33 NC_051837.1 (26577319..26724145, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 33 NC_006615.4 (26367988..26513164, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 33 NC_049254.1 (26977815..27020671, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 33 NC_049293.1 (26374397..26519530, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 33 NC_049774.1 (26418883..26564205, complement)

    Chromosome 33 - NC_051837.1Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase family A member 5 Neighboring gene SEC22 homolog A, vesicle trafficking protein Neighboring gene uncharacterized LOC119867337 Neighboring gene uncharacterized LOC119867339 Neighboring gene uncharacterized LOC119867338 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene uncharacterized LOC111093817 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo generation of an adenylylcyclase isoform with a half-molecule motif. Katsushika S, et al. J Biol Chem, 1993 Feb 5. PMID 8428899
    2. Isolation and characterization of a novel cardiac adenylylcyclase cDNA. Ishikawa Y, et al. J Biol Chem, 1992 Jul 5. PMID 1618857
    3. Two-metal-Ion catalysis in adenylyl cyclase. Tesmer JJ, et al. Science, 1999 Jul 30. PMID 10427002
    4. Adenylyl cyclase type 5 protein expression during cardiac development and stress. Hu CL, et al. Am J Physiol Heart Circ Physiol, 2009 Nov. PMID 19734365, Free PMC Article
    5. Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s. Baragli A, et al. Cell Signal, 2008 Mar. PMID 18164588

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Generate transgenic mice overexpressing canine adenylyl cyclase 5.
      Title: Adenylyl cyclase type 5 protein expression during cardiac development and stress.
    2. Show that adenylyl cyclases 2 and 5 can form a functional heterodimeric complex in HEK293 cells and mouse myocardium.
      Title: Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenylate cyclase type 5
    Names
    ATP pyrophosphate-lyase 5
    adenylate cyclase type V
    adenylyl cyclase 5
    adenylyl cyclase type V
    ca(2+)-inhibitable adenylyl cyclase
    NP_001161932.1
    XP_038300498.1
    XP_038300499.1
    XP_038300500.1
    XP_038300501.1
    XP_038300502.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168460.1 → NP_001161932.1  adenylate cyclase type 5

      See identical proteins and their annotated locations for NP_001161932.1

      Status: PROVISIONAL

      Source sequence(s)
      M88649
      UniProtKB/Swiss-Prot
      P30803
      UniProtKB/TrEMBL
      A0A8C0NP47
      Related
      ENSCAFP00845033585.1, ENSCAFT00845042843.1
      Conserved Domains (3) summary
      pfam00211
      Location:1066 → 1260
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:1 → 461
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:671 → 763
      DUF1053; Domain of Unknown Function (DUF1053)

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051837.1 Reference ROS_Cfam_1.0

      Range
      26577319..26724145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038444571.1 → XP_038300499.1  adenylate cyclase type 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I3S4F1
      Conserved Domains (3) summary
      pfam00211
      Location:1135 → 1329
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:1 → 461
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:671 → 763
      DUF1053; Domain of Unknown Function (DUF1053)

    2. XM_038444572.1 → XP_038300500.1  adenylate cyclase type 5 isoform X3

      UniProtKB/TrEMBL
      A0A8C0RL14, A0A8P0SH25
      Conserved Domains (3) summary
      pfam00211
      Location:1103 → 1297
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:1 → 461
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:671 → 763
      DUF1053; Domain of Unknown Function (DUF1053)

    3. XM_038444570.1 → XP_038300498.1  adenylate cyclase type 5 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RL14, A0A8P0SH25
      Conserved Domains (3) summary
      pfam00211
      Location:1172 → 1366
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:1 → 461
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:671 → 763
      DUF1053; Domain of Unknown Function (DUF1053)

    4. XM_038444574.1 → XP_038300502.1  adenylate cyclase type 5 isoform X5

      Conserved Domains (3) summary
      pfam00211
      Location:832 → 1026
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:42 → 121
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:331 → 423
      DUF1053; Domain of Unknown Function (DUF1053)

    5. XM_038444573.1 → XP_038300501.1  adenylate cyclase type 5 isoform X4

      UniProtKB/TrEMBL
      A0A8C0TMF4
      Conserved Domains (3) summary
      pfam00211
      Location:463 → 636
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:1 → 461
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:671 → 763
      DUF1053; Domain of Unknown Function (DUF1053)

    RNA

    1. XR_005306012.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049293.1 Alternate UMICH_Zoey_3.1

      Range
      26374397..26519530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049774.1 Alternate UNSW_CanFamBas_1.0

      Range
      26418883..26564205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049254.1 Alternate UU_Cfam_GSD_1.0

      Range
      26977815..27020671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006615.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      26367988..26513164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30803.2 GenPept UniProtKB/Swiss-Prot:P30803

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