rho.L rhodopsin L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: rho.L
Official Full Name: rhodopsin L homeolog
Primary source: Xenbase:XB-GENE-966893
Locus tag: XELAEV_18023944mg
See related: EnsemblRapid:ENSXLAG00005035914
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: rh1; rho; rp4; opn2; xrho
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Genomic context

Location:: chromosome: 4L

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (131404895..131408777)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (126162815..126166697)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We examine and compare the contribution of endoplasmic reticulum stress to retinal degeneration in several vertebrate models of retinitis pigmentosa generated through expression of mutant rhodopsins.
Title: Endoplasmic reticulum stress in vertebrate mutant rhodopsin models of retinal degeneration.
Retinal degeneration in the P23H (proline-to-histidine) rhodopsin mutation is partially reversed, with regeneration of rod photoreceptors recovering normal morphology in a retinitis pigmentosa model.
Title: Dysmorphic photoreceptors in a P23H mutant rhodopsin model of retinitis pigmentosa are metabolically active and capable of regenerating to reverse retinal degeneration.
The newly identified ciliary targeting VxPx motif present in rhodopsin binds the small GTPase Arf4 and regulates its association with the trans-Golgi network.
Title: Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4.
These results support a role for rhoP23H misfolding and inner segment accumulation in rod death.
Title: Characterization of rhodopsin P23H-induced retinal degeneration in a Xenopus laevis model of retinitis pigmentosa.
the Xenopus rhodopsin gene has conserved transcriptional activators
Title: Conserved transcriptional activators of the Xenopus rhodopsin gene.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G protein-coupled photoreceptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables photoreceptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to light stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phototransduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rhodopsin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087048.2 → NP_001080517.1 rhodopsin

See identical proteins and their annotated locations for NP_001080517.1

Status: PROVISIONAL

Source sequence(s)

BC054145

UniProtKB/Swiss-Prot

P29403

UniProtKB/TrEMBL

Q7SZ45

Related

ENSXLAP00005107379.1, ENSXLAT00005109505.1

Conserved Domains (3) summary

pfam00001
Location:55 → 306

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam10413
Location:2 → 37

Rhodopsin_N; Amino terminal of the G-protein receptor rhodopsin

cl21561
Location:127 → 323

7tm_4; Olfactory receptor