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    CG3776 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37996, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG3776provided by FlyBase
    Primary source
    FLYBASE:FBgn0035088
    Locus tag
    Dmel_CG3776
    See related
    AllianceGenome:FB:FBgn0035088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3776; DmP29; EP(2)0835; Jhebp29; P29
    Summary
    Predicted to enable ribosome binding activity. Predicted to be involved in inner mitochondrial membrane organization and protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrion. Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to human MAIP1 (matrix AAA peptidase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    60E11-60E11; 2-107 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24969678..24970855)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20857201..20858378)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene cGAS-like receptor 2 Neighboring gene Ribosomal protein L19 Neighboring gene Pherokine 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45252

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Drosophila juvenile hormone esterase binding protein results in anti-JH effects and reduced pheromone abundance. Liu Z, et al. Gen Comp Endocrinol, 2008 Mar 1. PMID 18275960
    2. Localization of a Drosophila melanogaster homolog of the putative juvenile hormone esterase binding protein of Manduca sexta. Liu Z, et al. Insect Biochem Mol Biol, 2007 Feb. PMID 17244544
    3. Potential ligands of DmP29, a putative juvenile hormone esterase binding protein of Drosophila melanogaster. Liu Z, et al. Insect Biochem Mol Biol, 2007 Aug. PMID 17628282
    4. Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC). Borrás T, et al. Genetics, 2003 Feb. PMID 12618402, Free PMC Article
    5. A misexpression study examining dorsal thorax formation in Drosophila melanogaster. Peña-Rangel MT, et al. Genetics, 2002 Mar. PMID 11901120, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Underexpression of DmP29 resulted in reduced longevity, increased fecundity and reduced titers of pupal juvenile hormone esterase.
      Title: Overexpression of Drosophila juvenile hormone esterase binding protein results in anti-JH effects and reduced pheromone abundance.
    2. Recombinant DmP29 was shown by ligand blot and co-immunoprecipitation analyses to bind recombinant juvenile hormone esterase as well as to larval serum proteins (LSP).
      Title: Potential ligands of DmP29, a putative juvenile hormone esterase binding protein of Drosophila melanogaster.
    3. homolog of P29, a putative juvenile hormone esterase binding protein isolated from the tobacco hornworm Manduca sexta
      Title: Localization of a Drosophila melanogaster homolog of the putative juvenile hormone esterase binding protein of Manduca sexta.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial inner membrane from matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3776-PA
    CG3776-PB
    CG3776-PC
    drosophila P29
    juvenile hormone esterase binding protein 29

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24969678..24970855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299939.1 → NP_001286868.1  uncharacterized protein Dmel_CG3776, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0X3
      Conserved Domains (1) summary
      cl09208
      Location:101 → 144
      Tim44; Tim44-like domain

    2. NM_138145.3 → NP_611989.1  uncharacterized protein Dmel_CG3776, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611989.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0X3
      Related
      FBpp0072302
      Conserved Domains (1) summary
      cl09208
      Location:101 → 144
      Tim44; Tim44-like domain

    3. NM_001299940.1 → NP_001286869.1  uncharacterized protein Dmel_CG3776, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHN1
      Conserved Domains (1) summary
      cl09208
      Location:101 → 144
      Tim44; Tim44-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHN1 A0A0B4LHN1
    Q9W0X3 Q9W0X3

    Gene LinkOut

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