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    A34R temporal expression: late [ Vaccinia virus ]

    Gene ID: 3707687, updated on 18-Aug-2023

    Summary

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    Gene symbol
    A34R
    Gene description
    temporal expression: late
    Locus tag
    VACWR157
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Vaccinia virus (strain: WR (Western Reserve))
    Lineage
    Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; Orthopoxvirus
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    Genomic context

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    Sequence:
    NC_006998.1 (143912..144418)

    NC_006998.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene temporal expression: late Neighboring gene EEV membrane phosphoglycoprotein Neighboring gene hypothetical protein Neighboring gene temporal expression: early/late

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_006998.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vaccinia virus A34 glycoprotein determines the protein composition of the extracellular virus envelope. Perdiguero B, et al. J Virol, 2008 Mar. PMID 18094186, Free PMC Article
    2. The vaccinia virus B5 protein requires A34 for efficient intracellular trafficking from the endoplasmic reticulum to the site of wrapping and incorporation into progeny virions. Earley AK, et al. J Virol, 2008 Mar. PMID 18094183, Free PMC Article
    3. Resistance of a vaccinia virus A34R deletion mutant to spontaneous rupture of the outer membrane of progeny virions on the surface of infected cells. Husain M, et al. Virology, 2007 Sep 30. PMID 17553539, Free PMC Article
    4. Transport and stability of the vaccinia virus A34 protein is affected by the A33 protein. Breiman A, et al. J Gen Virol, 2013 Apr. PMID 23255618, Free PMC Article
    5. Vaccinia Virus Glycoproteins A33, A34, and B5 Form a Complex for Efficient Endoplasmic Reticulum to trans-Golgi Network Transport. Monticelli SR, et al. J Virol, 2020 Mar 17. PMID 31941777, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vaccinia Virus Glycoproteins A33, A34, and B5 Form a Complex for Efficient Endoplasmic Reticulum to trans-Golgi Network Transport.
      Title: Vaccinia Virus Glycoproteins A33, A34, and B5 Form a Complex for Efficient Endoplasmic Reticulum to trans-Golgi Network Transport.
    2. The localization and stability of A34 is affected by B5 and here data are presented showing that A34 is also affected by A33.
      Title: Transport and stability of the vaccinia virus A34 protein is affected by the A33 protein.
    3. the envelope of A34-deficient virus contained normal amounts of F13 but decreased amounts of A33 and B5 with respect to the parental WR virus. These results point to A34 as a major determinant in the protein composition of the vaccinia virus envelope
      Title: Vaccinia virus A34 glycoprotein determines the protein composition of the extracellular virus envelope.
    4. studies confirmed that B5 and A34 interact through their luminal domains, and further analysis revealed that in the absence of A34, B5 is not efficiently incorporated into virions released from the cell
      Title: The vaccinia virus B5 protein requires A34 for efficient intracellular trafficking from the endoplasmic reticulum to the site of wrapping and incorporation into progeny virions.
    5. Studies with several mutant viruses indicated that EV membranes lacking the A34 protein were unbroken.
      Title: Resistance of a vaccinia virus A34R deletion mutant to spontaneous rupture of the outer membrane of progeny virions on the surface of infected cells.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    IEV and EEV membrane glycoprotein
    YP_233039.1
    • IEV and EEV membrane glycoprotein; similar to vaccinia virus strain Copenhagen A34R; C-type lectin-like protein found on extracellular enveloped virions (EEV); The poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_006998.1 Reference assembly

      Range
      143912..144418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_233039.1 EEV glycoprotein [Vaccinia virus]

      See identical proteins and their annotated locations for YP_233039.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P24761, Q76ZP2
      UniProtKB/TrEMBL
      A0A2I2MDQ1, A0A2I6TE07, A0A2P1JPW1, A9J0X0, O57237, Q1M1G2, Q9JF62
      Conserved Domains (1) summary
      PHA02953
      Location:1 → 168
      PHA02953; IEV and EEV membrane glycoprotein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAO89436.1

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