Sod2 Superoxide dismutase 2 (Mn) [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sod2provided by FlyBase
Official Full Name: Superoxide dismutase 2 (Mn)provided by FlyBase
Primary source: FLYBASE:FBgn0010213
Locus tag: Dmel_CG8905
See related: AllianceGenome:FB:FBgn0010213
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8905; Dmel\CG8905; dSod2; dSOD2; Mito SOD; mitSOD2; Mn SOD; Mn-SOD; MN-SOD; Mn-SOD2; mnSOD; MnSod; MnSOD; MnSODa; MnSODII; Mn[2+]SOD; Sod; SOD; Sod-2; SOD-2; SOD-m; sod2; SOD2
Summary: Predicted to enable manganese ion binding activity and superoxide dismutase activity. Involved in several processes, including determination of adult lifespan; paracrine signaling; and regulation of hemocyte proliferation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; embryonic/larval midgut primordium; and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); lipid storage disease (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 53D8-53D8; 2-80 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16772785..16773915, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12660290..12661420, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depletion of superoxide dismutases promotes muscular and neuronal ROS accumulation which may have a significant effect on age-dependent impairment of the Drosophila adults.
Title: A correlation of reactive oxygen species accumulation by depletion of superoxide dismutases with age-dependent impairment in the nervous system and muscles of Drosophila adults.
Paraquat exposure, but not Sod2 knockdown, resulted in increased carbonylated protein relative abundance.
Title: Paraquat exposure and Sod2 knockdown have dissimilar impacts on the Drosophila melanogaster carbonylated protein proteome.
The functional SOD1 and SOD2 genes knockout and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress conditions.
Title: [Influence of tissue-specific superoxide dismutase genes expression in brain cells on Drosophila melanogaster sensitivity to oxidative stress and viability].
ocytes lacking maternal SOD2 protein develop into adults just like normal SOD2-containing oocytes suggesting that maternal SOD2-mediated protection against mitochondrial ROS is not essential for oocyte viability
Title: SOD2, the principal scavenger of mitochondrial superoxide, is dispensable for embryogenesis and imaginal tissue development but essential for adult survival.
knockdown in the musculature has whole-organism consequences
Title: Sod2 knockdown in the musculature has whole-organism consequences in Drosophila.
Muscles appear to be more sensitive to superoxide attack relative to the neurons and such overt phenotypes observed in SOD2-deficient animals can be directly attributed to the muscle.
Title: Mitochondrial superoxide radicals differentially affect muscle activity and neural function.
Data show that the decline of several functional measures of aging occurs, in an accelerated fashion, in Sod2 mutants.
Title: Multiple measures of functionality exhibit progressive decline in a parallel, stochastic fashion in Drosophila Sod2 null mutants.
switching moribund SOD2-deficient adults from normoxia into hypoxia arrests premature mortality and endows the survivors with a near-normal life
Title: Hypoxia rescues early mortality conferred by superoxide dismutase deficiency.
Disruption of the protective effects of SOD2 on mitochondria manifests as profound changes in behavioral and demographic aging as well as exacerbated age-related pathology in the nervous system.
Title: Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging.
SOD1 and SOD2 provide independent protection to compartment-specific protein iron-sulfur clusters against attack by superoxide generated under oxidative stress
Title: Compartment-specific protection of iron-sulfur proteins by superoxide dismutase.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables antioxidant activity	NAS Non-traceable Author Statement more info	PubMed
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	TAS Traceable Author Statement more info	PubMed
involved_in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in paracrine signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy of mitochondrion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in removal of superoxide radicals	ISS Inferred from Sequence or Structural Similarity more info
involved_in superoxide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: superoxide dismutase 2 (Mn)

Names: CG8905-PA; CG8905-PB; Mn superoxide dismutase; Mn-superoxide dismutase; MnSOD; Sod2-PA; Sod2-PB; Superoxidedismutase2 (Mn); manganese superoxide dismutase; manganese-SOD; mitochodnrial SOD; mitochondrial Mn-superoxide dismutase 2; mitochondrial MnSOD; mitochondrial superoxide dismutase 2; superoxide dismutase; superoxide dismutase 2; superoxide dismutase-2; superoxide dismutases 2; superoxide dismutatase 2

NP_001286503.1

EC 1.15.1.1

NP_476925.1

EC 1.15.1.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16772785..16773915 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299574.1 → NP_001286503.1 superoxide dismutase 2 (Mn), isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286503.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q00637, Q9V7T8

UniProtKB/TrEMBL

A0A0B4LGQ1

Conserved Domains (3) summary

COG0605
Location:16 → 214

SodA; Superoxide dismutase [Inorganic ion transport and metabolism]

pfam00081
Location:18 → 99

Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain

pfam02777
Location:105 → 208

Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain
NM_057577.4 → NP_476925.1 superoxide dismutase 2 (Mn), isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476925.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q00637, Q9V7T8

UniProtKB/TrEMBL

A0A0B4LGQ1

Related

FBpp0086226

Conserved Domains (3) summary

COG0605
Location:16 → 214

SodA; Superoxide dismutase [Inorganic ion transport and metabolism]

pfam00081
Location:18 → 99

Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain

pfam02777
Location:105 → 208

Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain