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    Ccser2 coiled-coil serine-rich protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306306, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ccser2provided by RGD
    Official Full Name
    coiled-coil serine-rich protein 2provided by RGD
    Primary source
    RGD:1304626
    See related
    Ensembl:ENSRNOG00000022781 AllianceGenome:RGD:1304626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gcap14; Fam190b; RGD1304626
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in microtubule bundle formation. Predicted to be active in microtubule cytoskeleton. Orthologous to human CCSER2 (coiled-coil serine rich protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 290.9), Muscle (RPKM 241.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    16p14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (12633374..12746045, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (12613103..12725764, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (14090547..14210512, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene tumor protein, translationally-controlled 1 like 2 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA15 Neighboring gene uncharacterized LOC134482323 Neighboring gene retinal G protein coupled receptor Neighboring gene leucine-rich repeat, Ig-like and transmembrane domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The murine Gcap14 gene encodes a novel microtubule binding and bundling protein. Hosono H, et al. FEBS Lett, 2012 May 21. PMID 22673506
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine-rich coiled-coil domain-containing protein 2
    Names
    family with sequence similarity 190, member B
    granule cell antiserum positive 14
    protein FAM190B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427501.1 → NP_001414430.1  serine-rich coiled-coil domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D4A4E5

    2. NM_001427502.1 → NP_001414431.1  serine-rich coiled-coil domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6A5N0, A6K9I4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      12633374..12746045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600329.3 → XP_017455818.2  serine-rich coiled-coil domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5N0, A6K9I4

    2. XM_039095013.2 → XP_038950941.1  serine-rich coiled-coil domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A6K9I5

    3. XM_039095014.2 → XP_038950942.1  serine-rich coiled-coil domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A6K9I5

    4. XM_039095016.2 → XP_038950944.1  serine-rich coiled-coil domain-containing protein 2 isoform X6

    5. XM_039095015.2 → XP_038950943.1  serine-rich coiled-coil domain-containing protein 2 isoform X6

    6. XM_063275367.1 → XP_063131437.1  serine-rich coiled-coil domain-containing protein 2 isoform X3

    7. XM_063275366.1 → XP_063131436.1  serine-rich coiled-coil domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GG47

    8. XM_063275368.1 → XP_063131438.1  serine-rich coiled-coil domain-containing protein 2 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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