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    Selenoh selenoprotein H [ Mus musculus (house mouse) ]

    Gene ID: 72657, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Selenohprovided by MGI
    Official Full Name
    selenoprotein Hprovided by MGI
    Primary source
    MGI:MGI:1919907
    See related
    Ensembl:ENSMUSG00000076437 AllianceGenome:MGI:1919907
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Selh; 2700094K13Rik
    Summary
    This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]
    Expression
    Broad expression in CNS E11.5 (RPKM 111.9), limb E14.5 (RPKM 56.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 D; 2 49.45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84499559..84501052, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84669215..84670708, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene catenin delta 1 Neighboring gene STARR-positive B cell enhancer ABC_E2627 Neighboring gene BTB domain containing 18 Neighboring gene STARR-positive B cell enhancer ABC_E13 Neighboring gene thioredoxin-related transmembrane protein 2 Neighboring gene mediator complex subunit 19 Neighboring gene zinc finger, DHHC domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_05007

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpression of selenoprotein H prevents mitochondrial dynamic imbalance induced by glutamate exposure. Ma YM, et al. Int J Biol Sci, 2017. PMID 29535592, Free PMC Article
    2. Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. Novoselov SV, et al. J Biol Chem, 2007 Apr 20. PMID 17337453
    3. SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Dikiy A, et al. Biochemistry, 2007 Jun 12. PMID 17503775
    4. Characterization of mammalian selenoproteomes. Kryukov GV, et al. Science, 2003 May 30. PMID 12775843
    5. Selenoprotein Gene Nomenclature. Gladyshev VN, et al. J Biol Chem, 2016 Nov 11. PMID 27645994, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of selenoprotein H can protect cells from glutamate toxicity by preserving mitochondrial morphology and suppressing autophagy.
      Title: Overexpression of selenoprotein H prevents mitochondrial dynamic imbalance induced by glutamate exposure.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    selenoprotein H

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033166.3 → NP_001028338.1  selenoprotein H

      See identical proteins and their annotated locations for NP_001028338.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AV508490, BC056177, BY239096
      Consensus CDS
      CCDS16187.1
      UniProtKB/Swiss-Prot
      Q3UQA7, Q7TNQ0
      UniProtKB/TrEMBL
      A0A087WPM0
      Related
      ENSMUSP00000112635.4, ENSMUST00000117299.10
      Conserved Domains (1) summary
      cl01407
      Location:30 → 113
      Rdx; Rdx family

    2. NM_001037279.2 → NP_001032356.1  selenoprotein H

      See identical proteins and their annotated locations for NP_001032356.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon in the 3' non-coding region compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK012609, AV508490, BY239096
      Consensus CDS
      CCDS16187.1
      UniProtKB/Swiss-Prot
      Q3UQA7, Q7TNQ0
      UniProtKB/TrEMBL
      A0A087WPM0
      Related
      ENSMUSP00000099707.5, ENSMUST00000102647.11
      Conserved Domains (1) summary
      cl01407
      Location:30 → 113
      Rdx; Rdx family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      84499559..84501052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UQA7.2 GenPept UniProtKB/Swiss-Prot:Q3UQA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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