Acot7 acyl-CoA thioesterase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acot7provided by RGD
Official Full Name: acyl-CoA thioesterase 7provided by RGD
Primary source: RGD:628856
See related: Ensembl:ENSRNOG00000010580 AllianceGenome:RGD:628856
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bach
Summary: Enables acyl-CoA hydrolase activity. Predicted to be involved in fatty acid biosynthetic process and purine nucleoside bisphosphate metabolic process. Predicted to act upstream of or within fatty acid catabolic process. Located in cytosol. Orthologous to human ACOT7 (acyl-CoA thioesterase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 145.7), Testes (RPKM 126.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (167969284..168062033)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (162686562..162779309)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (169357582..169450215)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

Acot7 (e-PCR), detects polymorphism
- UniSTS:546626

AU042212 (e-PCR)
- UniSTS:159331

RH126892 (e-PCR)
- UniSTS:207733

RH129039 (e-PCR)
- UniSTS:212347

D1S2335E (e-PCR)
- UniSTS:147361

AW557066 (e-PCR)
- UniSTS:179118

ACOT7 (e-PCR)
- UniSTS:503283

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables fatty acyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty-acyl-CoA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in coenzyme A biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in coenzyme A biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fatty acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty-acyl-CoA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty-acyl-CoA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in medium-chain fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in medium-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in medium-chain fatty-acyl-CoA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in medium-chain fatty-acyl-CoA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in palmitic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in palmitic acid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytosolic acyl coenzyme A thioester hydrolase

Names: ACH1; ACT; CTE-II; CTE-IIa; CTE-IIb; LACH1; MTE-II; brain acyl-CoA hydrolase; long chain acyl-CoA thioester hydrolase

NP_001139533.1

EC 3.1.2.2

NP_037346.2

EC 3.1.2.2

XP_006239510.1

EC 3.1.2.2

XP_038965267.1

EC 3.1.2.2

XP_038965268.1

EC 3.1.2.2

XP_038965271.1

EC 3.1.2.2

XP_063143288.1

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146061.1 → NP_001139533.1 cytosolic acyl coenzyme A thioester hydrolase isoform 1

See identical proteins and their annotated locations for NP_001139533.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC087716, D88891

UniProtKB/Swiss-Prot

O08652, O09041, Q64559

UniProtKB/TrEMBL

A0A8L2Q6N9, A6IUH6

Related

ENSRNOP00000014213.3, ENSRNOT00000014213.5

Conserved Domains (1) summary

cd03442
Location:223 → 346

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
NM_013214.4 → NP_037346.2 cytosolic acyl coenzyme A thioester hydrolase isoform 2

See identical proteins and their annotated locations for NP_037346.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (2) with a distinct and shorter N-terminus, compared to isoform 1.

Source sequence(s)

BC087716, DY317682

UniProtKB/TrEMBL

A0A8I6ACH7, A6IUH5

Related

ENSRNOP00000089356.1, ENSRNOT00000118204.1

Conserved Domains (2) summary

cd03442
Location:214 → 337

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

pfam16136
Location:174 → 199

NINJA_B; Putative nuclear localization signal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

167969284..168062033

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109340.2 → XP_038965268.1 cytosolic acyl coenzyme A thioester hydrolase isoform X2

UniProtKB/TrEMBL

A0A8I6ACH7

Conserved Domains (2) summary

PLN02647
Location:243 → 330

PLN02647; acyl-CoA thioesterase

cd03442
Location:50 → 155

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
XM_063287218.1 → XP_063143288.1 cytosolic acyl coenzyme A thioester hydrolase isoform X4
XM_039109339.2 → XP_038965267.1 cytosolic acyl coenzyme A thioester hydrolase isoform X1

UniProtKB/TrEMBL

A0A8L2Q6N9

Conserved Domains (2) summary

PLN02647
Location:252 → 339

PLN02647; acyl-CoA thioesterase

cd03442
Location:59 → 164

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
XM_006239448.3 → XP_006239510.1 cytosolic acyl coenzyme A thioester hydrolase isoform X3

UniProtKB/TrEMBL

F8WG67

Conserved Domains (1) summary

cd03442
Location:163 → 286

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
XM_039109343.2 → XP_038965271.1 cytosolic acyl coenzyme A thioester hydrolase isoform X5

Conserved Domains (1) summary

cd03442
Location:61 → 184

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...