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    Eif5b eukaryotic translation initiation factor 5B [ Mus musculus (house mouse) ]

    Gene ID: 226982, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Eif5bprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 5Bprovided by MGI
    Primary source
    MGI:MGI:2441772
    See related
    Ensembl:ENSMUSG00000026083 AllianceGenome:MGI:2441772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IF2; A030003E17Rik
    Summary
    Predicted to enable translation initiation factor activity. Predicted to be involved in regulation of translational initiation. Predicted to be located in cytoplasm. Orthologous to human EIF5B (eukaryotic translation initiation factor 5B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 15.1), liver E14 (RPKM 11.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 B; 1 16.4 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (38037091..38094660)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37998010..38055579)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00687 Neighboring gene STARR-positive B cell enhancer ABC_E3269 Neighboring gene STARR-positive B cell enhancer ABC_E10006 Neighboring gene lysozyme G-like 1 Neighboring gene STARR-seq mESC enhancer starr_00688 Neighboring gene thioredoxin domain containing 9 Neighboring gene STARR-seq mESC enhancer starr_00689 Neighboring gene predicted gene, 34448 Neighboring gene STARR-seq mESC enhancer starr_00690 Neighboring gene STARR-seq mESC enhancer starr_00691 Neighboring gene REV1, DNA directed polymerase Neighboring gene predicted gene 5099 Neighboring gene AF4/FMR2 family, member 3 Neighboring gene predicted gene 16150

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages. Lee S, et al. Proc Natl Acad Sci U S A, 2014 Oct 14. PMID 25261552, Free PMC Article
    2. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. Bohnsack MT, et al. EMBO J, 2002 Nov 15. PMID 12426392, Free PMC Article
    3. Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome. Li R, et al. PLoS Genet, 2016 Jun. PMID 27352031, Free PMC Article
    4. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Borgal L, et al. Cell Cycle, 2016. PMID 26919559, Free PMC Article
    5. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. eIF5B overexpression promotes maturation of G0-like immature oocytes and causes cell death, an alternative to G0, in serum-starved THP1 cells.
      Title: Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages.
    2. eIF5B, the homologue of bacterial IF2, is a GTPase implicated in joining the ribosomal subunits.
      Title: Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 5B
    Names
    eIF-5B
    translation initiation factor IF-2
    NP_938045.2
    XP_036020208.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198303.2 → NP_938045.2  eukaryotic translation initiation factor 5B

      See identical proteins and their annotated locations for NP_938045.2

      Status: VALIDATED

      Source sequence(s)
      AK145732, AK173016, BC103806, CN670500, CN724918
      Consensus CDS
      CCDS35544.1
      UniProtKB/Swiss-Prot
      Q05D44, Q3SYI4, Q3TQJ8, Q3UL37, Q3UM39, Q6PAI0, Q8CFF4, Q8CGD6
      Related
      ENSMUSP00000027252.8, ENSMUST00000027252.8
      Conserved Domains (5) summary
      cd01887
      Location:628 → 841
      IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
      PRK04004
      Location:623 → 1198
      PRK04004; translation initiation factor IF-2; Validated
      pfam11987
      Location:962 → 1063
      IF-2; Translation-initiation factor 2
      cd03703
      Location:851 → 961
      aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
      cd16266
      Location:1088 → 1182
      IF2_aeIF5B_IV; Domain IV of prokaryotic Initiation Factor 2 and archaeal and eukaryotic Initiation Factor 5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      38037091..38094660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164315.1 → XP_036020208.1  eukaryotic translation initiation factor 5B isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05D44.2 GenPept UniProtKB/Swiss-Prot:Q05D44

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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