csp-2 Putative inactive caspase subunit p14 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: csp-2
Gene description: Putative inactive caspase subunit p14
Primary source: WormBase:WBGene00000820
Locus tag: CELE_Y73B6BL.7
See related: AllianceGenome:WB:WBGene00000820
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables caspase binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and zymogen binding activity. Involved in positive regulation of brood size; positive regulation of fertilization; and regulation of apoptotic process. Part of protease inhibitor complex. Is expressed in germ line. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CASP6 (caspase 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 16

Sequence:: Chromosome: IV; NC_003282.8 (6307739..6315719)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caspase homologs CSP-2 lacking protease activities serve as dedicated caspase inhibitors in C. elegans to prevent CED-3 from inadvertent autoactivation and cells from apoptosis.
Title: Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables caspase binding	IPI Inferred from Physical Interaction more info	PubMed
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables zymogen binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in inhibition of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic process involved in development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of brood size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fertilization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of protease inhibitor complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Putative inactive caspase subunit p14

NP_001368631.1

Confirmed by transcript evidence

NP_001368632.1

Confirmed by transcript evidence

NP_001370851.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6307739..6315719

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383103.2 → NP_001370851.1 Putative inactive caspase subunit p14 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

PHA03418
Location:475 → 563

PHA03418; hypothetical E4 protein; Provisional

cd00032
Location:581 → 824

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

NF033930
Location:239 → 533

pneumo_PspA; pneumococcal surface protein A
NM_001380264.1 → NP_001368632.1 Putative inactive caspase subunit p14 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

PHA03418
Location:376 → 464

PHA03418; hypothetical E4 protein; Provisional

cd00032
Location:482 → 725

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

NF033930
Location:140 → 434

pneumo_PspA; pneumococcal surface protein A
NM_001380265.1 → NP_001368631.1 Putative inactive caspase subunit p14 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1N7SZF9, G5ECY5, Q9TZP5

Conserved Domains (1) summary

cd00032
Location:18 → 261

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...