anmt-1 Nicotinamide N-methyltransferase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: anmt-1
Gene description: Nicotinamide N-methyltransferase
Primary source: WormBase:WBGene00015124
Locus tag: CELE_B0303.2
See related: AllianceGenome:WB:WBGene00015124
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable N-methyltransferase activity. Predicted to be involved in methylation. Located in striated muscle dense body and striated muscle myosin thick filament. Is expressed in body wall musculature; intestine; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in Alzheimer's disease; hypertension; and multiple sclerosis. Orthologous to human INMT (indolethylamine N-methyltransferase); NNMT (nicotinamide N-methyltransferase); and PNMT (phenylethanolamine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (8684808..8686408)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study reports an important role for N-methyl-transferase (NNMT) in regulation of autophagy during aging, where high neuronal ANMT-1 (the C. elegans NNMT ortholog) activity induces autophagy via NPRL-2, which maintains neuronal function in old wild type animals and various disease models, also affecting longevity.
Title: Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0303.2 (e-PCR)
- UniSTS:313384

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nicotinamide N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle dense body	HDA more info	PubMed
located_in striated muscle myosin thick filament	HDA more info	PubMed

General protein information

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Preferred Names: Nicotinamide N-methyltransferase

NP_498914.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8684808..8686408

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066513.7 → NP_498914.1 Nicotinamide N-methyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498914.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34254

Conserved Domains (1) summary

pfam01234
Location:20 → 272

NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family