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    nifk-1 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175614, updated on 23-Nov-2023

    Summary

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    Gene symbol
    nifk-1
    Gene description
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00011408
    Locus tag
    CELE_T04A8.6
    See related
    AllianceGenome:WB:WBGene00011408
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleolus. Is expressed in several structures, including anal depressor muscle; body wall musculature; excretory cell; nervous system; and pharynx. Orthologous to human NIFK (nucleolar protein interacting with the FHA domain of MKI67). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (4692098..4693307, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Costars domain-containing protein Neighboring gene Amidophosphoribosyltransferase Neighboring gene ncRNA Neighboring gene Rad60/SUMO-like domain-containing protein Neighboring gene 1,4-alpha-glucan branching enzyme

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesis. Voutev R, et al. Dev Biol, 2006 Oct 1. PMID 16876152
    2. Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs. Kelley LC, et al. Dev Cell, 2019 Feb 11. PMID 30686527, Free PMC Article
    3. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
    4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_497959.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4692098..4693307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065558.7 → NP_497959.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22135
      Conserved Domains (2) summary
      TIGR01645
      Location:45 → 249
      half-pint; poly-U binding splicing factor, half-pint family
      cd12307
      Location:33 → 106
      RRM_NIFK_like; RNA recognition motif in nucleolar protein interacting with the FHA domain of pKI-67 (NIFK) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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