U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    sptl-1 Aminotransferase class I/classII domain-containing protein;Serine palmitoyltransferase 1 [ Caenorhabditis elegans ]

    Gene ID: 173389, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    sptl-1
    Gene description
    Aminotransferase class I/classII domain-containing protein;Serine palmitoyltransferase 1
    Primary source
    WormBase:WBGene00016020
    Locus tag
    CELE_C23H3.4
    See related
    AllianceGenome:WB:WBGene00016020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine C-palmitoyltransferase activity. Involved in establishment or maintenance of epithelial cell apical/basal polarity. Predicted to be active in endoplasmic reticulum. Is expressed in head and intestine. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1A. Orthologous to human SPTLC1 (serine palmitoyltransferase long chain base subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (51652..57570)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative 26S proteasome regulatory subunit 10B Neighboring gene RNA polymerase I associated factor, A49-like protein Neighboring gene Nucleolus and neural progenitor protein-like N-terminal domain-containing protein Neighboring gene Trehalase Neighboring gene K Homology domain-containing protein Neighboring gene DUF3810 domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A Model of Hereditary Sensory and Autonomic Neuropathy Type 1 Reveals a Role of Glycosphingolipids in Neuronal Polarity. Cui M, et al. J Neurosci, 2019 Jul 17. PMID 31138658, Free PMC Article
    2. Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans. Cutler RG, et al. Mech Ageing Dev, 2014 Dec 15. PMID 25437839, Free PMC Article
    3. Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis. Zhang H, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926990, Free PMC Article
    4. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Deng X, et al. Science, 2008 Oct 3. PMID 18832646, Free PMC Article
    5. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine C-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine C-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Aminotransferase class I/classII domain-containing protein;Serine palmitoyltransferase 1
    NP_001021979.1
    • Confirmed by transcript evidence
    NP_001300513.1
    • Confirmed by transcript evidence
    NP_001379707.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      51652..57570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392983.1 → NP_001379707.1  Serine palmitoyltransferase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91079, Q5R3Y5
      Conserved Domains (1) summary
      cl18945
      Location:9 → 455
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    2. NM_001026808.4 → NP_001021979.1  Serine palmitoyltransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021979.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91079
      Conserved Domains (2) summary
      COG0156
      Location:50 → 427
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
      cl18945
      Location:13 → 431
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    3. NM_001313584.3 → NP_001300513.1  Aminotransferase class I/classII domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARH7
      Conserved Domains (1) summary
      cl18945
      Location:2 → 171
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91079.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous