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    SNHG14 small nucleolar RNA host gene 14 [ Homo sapiens (human) ]

    Gene ID: 104472715, updated on 12-Mar-2024

    Summary

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    Official Symbol
    SNHG14provided by HGNC
    Official Full Name
    small nucleolar RNA host gene 14provided by HGNC
    Primary source
    HGNC:HGNC:37462
    See related
    MIM:616259; AllianceGenome:HGNC:37462
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    115HG; LNCAT; UBE3A-AS; UBE3AATS; UBE3A-AS1; UBE3A-ATS; NCRNA00214; U-UBE3A-ATS; IC-SNURF-SNRPN
    Summary
    This gene is located within the Prader-Willi critical region and produces a long, spliced paternally-imprinted RNA that initiates within a common upstream promoter region shared by the SNRPN (small nuclear ribonucleoprotein polypeptide N) and SNURF genes. This transcript serves as a host RNA for the small nucleolar RNA, C/D box 115 and 116 clusters. This RNA extends in antisense into the region of the ubiquitin protein ligase E3A gene (UBE3A), and is thought to regulate imprinted expression of UBE3A in the brain. This transcript undergoes extensive alternative splicing, and may initiate and terminate at multiple locations within this genomic region. The full-length structure of all splice forms is not determined. [provided by RefSeq, Mar 2017]
    Orthologs
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    Genomic context

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    Location:
    15q11.2
    Exon count:
    148
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (24823608..25419462)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (22560260..23156060)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (25068755..25664609)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr15:24877390-24877896 Neighboring gene Prader-Willi region non-protein coding RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:24932126-24932730 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:24941505-24942052 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:24942053-24942599 Neighboring gene H3K27ac hESC enhancers GRCh37_chr15:25017418-25018314 and GRCh37_chr15:25018315-25019210 Neighboring gene nuclear pore associated protein 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25101506-25102019 Neighboring gene Sharpr-MPRA regulatory region 849 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25103559-25104072 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25104073-25104585 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:25107499-25108228 Neighboring gene small nucleolar RNA U13 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25143773-25144405 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:25145037-25145537 Neighboring gene small nuclear ribonucleoprotein polypeptide N Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25196020-25196660 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:25200549-25201114 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:25201115-25201680 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:25201681-25202246 Neighboring gene ribosomal protein S27 pseudogene 2 Neighboring gene ribosomal protein L5 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 7323 Neighboring gene small nucleolar RNA, C/D box 107 Neighboring gene small nucleolar RNA, C/D box 108 Neighboring gene SNRPN upstream open reading frame Neighboring gene small nucleolar RNA, C/D box 64 Neighboring gene uncharacterized LOC128966705 Neighboring gene Prader Willi/Angelman region RNA, SNRPN neighbor Neighboring gene small nucleolar RNA, C/D box 116-1 Neighboring gene small nucleolar RNA, C/D box 116-2 Neighboring gene small nucleolar RNA, C/D box 109A Neighboring gene small nucleolar RNA, C/D box 116-3 Neighboring gene small nucleolar RNA, C/D box 116-4 Neighboring gene Prader Willi/Angelman region RNA 5 Neighboring gene small nucleolar RNA, C/D box 116-10 Neighboring gene small nucleolar RNA, C/D box 116-5 Neighboring gene small nucleolar RNA, C/D box 116-11 Neighboring gene small nucleolar RNA, C/D box 116-12 Neighboring gene small nucleolar RNA, C/D box 116-6 Neighboring gene small nucleolar RNA, C/D box 116-15 Neighboring gene small nucleolar RNA, C/D box 116-14 Neighboring gene small nucleolar RNA, C/D box 116-13 Neighboring gene small nucleolar RNA, C/D box 116-17 Neighboring gene small nucleolar RNA, C/D box 116-16 Neighboring gene small nucleolar RNA, C/D box 116-7 Neighboring gene small nucleolar RNA, C/D box 116-18 Neighboring gene small nucleolar RNA, C/D box 116-20 Neighboring gene small nucleolar RNA, C/D box 116-19 Neighboring gene small nucleolar RNA, C/D box 116-8 Neighboring gene small nucleolar RNA, C/D box 116-9 Neighboring gene small nucleolar RNA, C/D box 116-21 Neighboring gene small nucleolar RNA, C/D box 116-22 Neighboring gene small nucleolar RNA, C/D box 116-23 Neighboring gene small nucleolar RNA, C/D box 116-24 Neighboring gene small nucleolar RNA, C/D box 116-25 Neighboring gene small nucleolar RNA, C/D box 116-26 Neighboring gene small nucleolar RNA, C/D box 116-27 Neighboring gene small nucleolar RNA, C/D box 116-28 Neighboring gene small nucleolar RNA, C/D box 116-29 Neighboring gene small nucleolar RNA, C/D box 116-30 Neighboring gene Prader Willi/Angelman region RNA 6 Neighboring gene uncharacterized LOC124903592 Neighboring gene small nucleolar RNA, C/D box 115-1 Neighboring gene small nucleolar RNA, C/D box 115-2 Neighboring gene small nucleolar RNA, C/D box 115-3 Neighboring gene small nucleolar RNA, C/D box 115-11 Neighboring gene small nucleolar RNA, C/D box 115-10 Neighboring gene small nucleolar RNA, C/D box 115-13 Neighboring gene small nucleolar RNA, C/D box 115-4 Neighboring gene small nucleolar RNA, C/D box 115-12 Neighboring gene small nucleolar RNA, C/D box 115-6 Neighboring gene small nucleolar RNA, C/D box 115-14 Neighboring gene small nucleolar RNA, C/D box 115-5 Neighboring gene small nucleolar RNA, C/D box 115-8 Neighboring gene small nucleolar RNA, C/D box 115-15 Neighboring gene small nucleolar RNA, C/D box 115-7 Neighboring gene small nucleolar RNA, C/D box 115-16 Neighboring gene small nucleolar RNA, C/D box 115-17 Neighboring gene small nucleolar RNA, C/D box 115-9 Neighboring gene small nucleolar RNA, C/D box 115-18 Neighboring gene small nucleolar RNA, C/D box 115-19 Neighboring gene small nucleolar RNA, C/D box 115-20 Neighboring gene small nucleolar RNA, C/D box 115-21 Neighboring gene small nucleolar RNA, C/D box 115-22 Neighboring gene small nucleolar RNA, C/D box 115-23 Neighboring gene small nucleolar RNA, C/D box 115-24 Neighboring gene small nucleolar RNA, C/D box 115-25 Neighboring gene small nucleolar RNA, C/D box 115-26 Neighboring gene small nucleolar RNA, C/D box 115-27 Neighboring gene small nucleolar RNA, C/D box 115-29 Neighboring gene small nucleolar RNA, C/D box 115-28 Neighboring gene small nucleolar RNA, C/D box 115-30 Neighboring gene Prader Willi/Angelman region RNA 1 Neighboring gene small nucleolar RNA, C/D box 115-31 Neighboring gene DMAC1 pseudogene 1 Neighboring gene small nucleolar RNA, C/D box 115-32 Neighboring gene small nucleolar RNA, C/D box 115-34 Neighboring gene small nucleolar RNA, C/D box 115-33 Neighboring gene small nucleolar RNA, C/D box 115-35 Neighboring gene small nucleolar RNA, C/D box 115-37 Neighboring gene imprinted in Prader-Willi syndrome Neighboring gene small nucleolar RNA, C/D box 115-36 Neighboring gene small nucleolar RNA, C/D box 115-38 Neighboring gene small nucleolar RNA, C/D box 115-39 Neighboring gene small nucleolar RNA, C/D box 115-40 Neighboring gene small nucleolar RNA, C/D box 115-41 Neighboring gene small nucleolar RNA, C/D box 115-42 Neighboring gene small nucleolar RNA, C/D box 115-43 Neighboring gene small nucleolar RNA, C/D box 115-44 Neighboring gene small nucleolar RNA, C/D box 115-45 Neighboring gene small nucleolar RNA, C/D box 115-46 Neighboring gene small nucleolar RNA, C/D box 115-47 Neighboring gene small nucleolar RNA, C/D box 115-48 Neighboring gene Prader Willi/Angelman region RNA 4 Neighboring gene small nucleolar RNA, C/D box 109B Neighboring gene Sharpr-MPRA regulatory region 5757 Neighboring gene ubiquitin protein ligase E3A Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr15:25683287-25684232 and GRCh37_chr15:25684233-25685178 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:25726194-25726733 Neighboring gene Sharpr-MPRA regulatory region 718 Neighboring gene long intergenic non-protein coding RNA 2250 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:25789643-25790842 Neighboring gene uncharacterized LOC107984789 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:25808594-25809158 Neighboring gene uncharacterized LOC124903448

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SNHG14 facilitates cell proliferation in colorectal cancer through targeting KRAS via Hippo-YAP signaling. Shen M, et al. Cell Mol Biol (Noisy-le-grand), 2023 Mar 31. PMID 37300688
    2. LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206 /SLC7A11 axis in osteosarcoma cells. Li L, et al. Cancer Gene Ther, 2023 May. PMID 36599973
    3. Long noncoding RNA SNHG14 knockdown exerts a neuroprotective role in MPP(+)-induced Parkinson's disease cell model through mediating miR-135b-5p/KPNA4 axis. Yuan X, et al. Metab Brain Dis, 2022 Oct. PMID 35781593
    4. Mechanism of Autonomic Exercise Improving Cognitive Function of Alzheimer's Disease by Regulating lncRNA SNHG14. He Y, et al. Am J Alzheimers Dis Other Demen, 2021 Jan-Dec. PMID 34338033, Free PMC Article
    5. Long non-coding RNA SNHG14 aggravates LPS-induced acute kidney injury through regulating miR-495-3p/HIPK1. Yang N, et al. Acta Biochim Biophys Sin (Shanghai), 2021 May 21. PMID 33856026

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Breast cancer-derived exosomal lncRNA SNHG14 induces normal fibroblast activation to cancer-associated fibroblasts via the EBF1/FAM171A1 axis.
      Title: Breast cancer-derived exosomal lncRNA SNHG14 induces normal fibroblast activation to cancer-associated fibroblasts via the EBF1/FAM171A1 axis.
    2. Inhibition of LncRNA SNHG14 protects chondrocyte from injury in osteoarthritis via sponging miR-137.
      Title: Inhibition of LncRNA SNHG14 protects chondrocyte from injury in osteoarthritis via sponging miR-137.
    3. SNHG14 facilitates cell proliferation in colorectal cancer through targeting KRAS via Hippo-YAP signaling.
      Title: SNHG14 facilitates cell proliferation in colorectal cancer through targeting KRAS via Hippo-YAP signaling.
    4. LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206 /SLC7A11 axis in osteosarcoma cells.
      Title: LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206 /SLC7A11 axis in osteosarcoma cells.
    5. Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader-Willi Syndrome Etiology.
      Title: Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader-Willi Syndrome Etiology.
    6. Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader-Willi Syndrome Etiology.
      Title: Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader-Willi Syndrome Etiology.
    7. Long noncoding RNA SNHG14 knockdown exerts a neuroprotective role in MPP(+)-induced Parkinson's disease cell model through mediating miR-135b-5p/KPNA4 axis.
      Title: Long noncoding RNA SNHG14 knockdown exerts a neuroprotective role in MPP(+)-induced Parkinson's disease cell model through mediating miR-135b-5p/KPNA4 axis.
    8. LncRNA SNHG14 is beneficial to oxygen glucose deprivation/reoxygenation-induced neuro-2a cell injury via mir-98-5p sequestration-caused BCL2L13 upregulation.
      Title: LncRNA SNHG14 is beneficial to oxygen glucose deprivation/reoxygenation-induced neuro-2a cell injury via mir-98-5p sequestration-caused BCL2L13 upregulation.
    9. LncRNA SNHG14 Sponges miR-206 to Affect Proliferation, Apoptosis, and Metastasis of Hepatocellular Carcinoma Cells by Regulating SOX9.
      Title: LncRNA SNHG14 Sponges miR-206 to Affect Proliferation, Apoptosis, and Metastasis of Hepatocellular Carcinoma Cells by Regulating SOX9.
    10. lncRNA SNHG14 promotes the proliferation, migration, and invasion of thyroid tumour cells by regulating miR-93-5p.
      Title: lncRNA SNHG14 promotes the proliferation, migration, and invasion of thyroid tumour cells by regulating miR-93-5p.
    Submit: New GeneRIF Correction See all GeneRIFs (53)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    Genotypes

    General gene information

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    Homology

    Other Names

    • UBE3A antisense RNA 1 (non-protein coding)
    • UBE3A antisense transcript
    • large noncoding antisense transcript
    • small nucleolar RNA host gene 14 (non-protein coding)

    Clone Names

    • DKFZp762N022, DKFZp686C0927, DKFZp686M12165

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_146177.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090983, AC124303, AC124312, AC124997, AF319524, AF400485, AF400486, AF400487, AF400490, AF400491, AF400492, AF400497, AF400498, AF400499, AF400501, AF400502, AY362864, AY362865, AY421730, BC080646, CN389953, DA296172, DN990150

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      24823608..25419462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      22560260..23156060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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