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    IL2 interleukin 2 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100302458, updated on 8-Mar-2024

    Summary

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    Gene symbol
    IL2
    Gene description
    interleukin 2
    See related
    Ensembl:ENSOCUG00000010100
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    TCGF
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 15
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 15 NC_067388.1 (95180093..95185241, complement)

    Chromosome 15 - NC_067388.1Genomic Context describing neighboring genes Neighboring gene bridge-like lipid transfer protein family member 1 Neighboring gene uncharacterized LOC127483213 Neighboring gene adenosine deaminase domain containing 1 Neighboring gene uncharacterized LOC108178069 Neighboring gene interleukin 21 Neighboring gene centrin-4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067388.1 Chromosome 15 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Role of interleukin 2 on apoptosis of lens epithelium cells in intraocular non-infective inflammation induced by iron]. Li XM, et al. Zhonghua Yan Ke Za Zhi, 2007 Oct. PMID 18201527
    2. The complete cDNA sequences of IL-2, IL-4, IL-6 AND IL-10 from the European rabbit (Oryctolagus cuniculus). Perkins HD, et al. Cytokine, 2000 Jun. PMID 10843729

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-2 activates the STAT3 pathway, protects the lens epithelium cells and reduce the damage caused by inflammation reactions.
      Title: [Role of interleukin 2 on apoptosis of lens epithelium cells in intraocular non-infective inflammation induced by iron].
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables interleukin-2 receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-2
    Names
    T-cell growth factor
    patial sequence of Interleukin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163180.1 → NP_001156652.1  interleukin-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001156652.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF068057
      UniProtKB/Swiss-Prot
      O77620, Q0MS71
      UniProtKB/TrEMBL
      A0A0N9HFH0, A0A0N9HRS8, A5YT96
      Related
      ENSOCUP00000008701.2, ENSOCUT00000010098.2
      Conserved Domains (1) summary
      pfam00715
      Location:7 → 149
      IL2; Interleukin 2

    2. NM_001171099.1 → NP_001164570.1  interleukin-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001164570.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The encoded protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AF169168
      UniProtKB/TrEMBL
      A5YT96, Q9MZR9
      Related
      ENSOCUP00000041258.1, ENSOCUT00000041329.1
      Conserved Domains (1) summary
      cl23879
      Location:7 → 129
      IL2; Interleukin 2

    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067388.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      95180093..95185241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77620.1 GenPept UniProtKB/Swiss-Prot:O77620

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