DMTF1 cyclin D binding myb-like transcription factor 1 [Homo sapiens] - Gene

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Summary

Official Symbol: DMTF1provided by HGNC
Official Full Name: cyclin D binding myb-like transcription factor 1provided by HGNC
Primary source: HGNC:14603
See related: Ensembl:ENSG00000135164; HPRD:09770; MIM:608491; Vega:OTTHUMG00000154135
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DMP1; DMTF; hDMP1; FLJ25188; FLJ41265; FLJ76054
Summary: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

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Genomic context

Location :: 7q21

Sequence :: Chromosome: 7; NC_000007.13 (86781677..86825648)

See DMTF1 in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
Loss of heterozygosity (LOH) of the hDMP1 gene was detectable in approximately 35% of human lung carcinomas, which was found in mutually exclusive fashion with LOH of INK4a/ARF or that of P53. DMP1 is a pivotal tumor suppressor for human lung cancers.
Title: Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer.
WT1 downregulation during myeloid differentiation of NB4 and HL60 leukemic cell lines is associated with increased tumor repressor hDMP1 mRNA levels
Title: The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias.
Observational study of gene-disease association. (HuGE Navigator)
Title: Single nucleotide polymorphisms in breast cancer.
hDMP1beta antagonizes hDMP1alpha activity and cellular functions of hDMP1 may be regulated by cellular hDMP1 isoform levels
Title: Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.

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Products	Interactant	Other Gene	Source	Pubs
Cyclin D binding myb like transcription factor 1	Activating transcription factor 7 interacting protein	ATF7IP	HPRD	PubMed
Cyclin D binding myb like transcription factor 1	P24385	CCND1	HPRD	PubMed
Cyclin D binding myb like transcription factor 1	P30279	CCND2	HPRD	PubMed
Cyclin D binding myb like transcription factor 1	P30281	CCND3	HPRD	PubMed

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

Preferred Names: cyclin-D-binding Myb-like transcription factor 1

Names: cyclin-D-binding Myb-like transcription factor 1; hDMTF1; cyclin D-binding Myb-like protein; cyclin-D-interacting Myb-like protein 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029536.1 RefSeqGene

Range

5001..48972

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001142326.1 → NP_001135798.1 cyclin-D-binding Myb-like transcription factor 1 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks a 5' coding exon, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b) with a shorter N-terminus compared to isoform a.

Source sequence(s)

AC005076, AF052102, AK002073, AK296211, BC070064

Consensus CDS

CCDS47633.1

UniProtKB/TrEMBL

B3KMJ8

UniProtKB/Swiss-Prot

Q9Y222

Related

ENSP00000412532, OTTHUMP00000205239, ENST00000432937, OTTHUMT00000334250

Conserved Domains (3) summary

cd00167
Location:187 – 241
Blast Score: 116

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

smart00717
Location:186 – 242
Blast Score: 131

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cl15779
Location:154 – 196
Blast Score: 120

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001142327.1 → NP_001135799.1 cyclin-D-binding Myb-like transcription factor 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AC005076, AF084530, AK002073, BC007418, DB069894

Consensus CDS

CCDS5601.1

UniProtKB/TrEMBL

B3KMJ8

UniProtKB/Swiss-Prot

Q9Y222

Related

ENSP00000332171, OTTHUMP00000205130, ENST00000331242, OTTHUMT00000334024

Conserved Domains (3) summary

cd00167
Location:275 – 329
Blast Score: 118

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

smart00717
Location:274 – 330
Blast Score: 133

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cl15779
Location:242 – 284
Blast Score: 121

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_021145.3 → NP_066968.3 cyclin-D-binding Myb-like transcription factor 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a, also known as DMP1alpha). Variants 1 and 2 encode the same isoform.

Source sequence(s)

AK002073, BC007447, BC070064, DB061156

Consensus CDS

CCDS5601.1

UniProtKB/TrEMBL

B3KMJ8

UniProtKB/Swiss-Prot

Q9Y222

Related

ENSP00000378193, ENST00000394703

Conserved Domains (3) summary

cd00167
Location:275 – 329
Blast Score: 118

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

smart00717
Location:274 – 330
Blast Score: 133

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cl15779
Location:242 – 284
Blast Score: 121

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RNA

NR_024549.1 RNA Sequence

Description

Transcript Variant: This variant (4) lacks two alternate internal exons and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as in variant 1, would result in nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC005076, AF202145, AK002073, BC007418, DB069894
NR_024550.1 RNA Sequence

Description

Transcript Variant: This variant (5) lacks two alternate internal exons and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as in variant 1, would result in nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC005076, AF202144, AK002073, BC007418, DB069894

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p5 Primary Assembly

Range

86781677..86825648

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

81392670..81436634

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

86113189..86157158

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC005076.2	AAD43181.1
genomic	CH236949.1 (10670531..10714253)	None
genomic	CH471091.2	EAW76962.1
		EAW76963.1
		EAW76964.1
		EAW76965.1
mRNA	AA258783.1	None
mRNA	AB209230.1	BAD92467.1
mRNA	AF052102.1	None
mRNA	AF084530.1	AAC33480.1
mRNA	AF202144.1	AAG35613.1
mRNA	AF202145.1	AAG35614.1
mRNA	AK002073.1	BAG51010.1
mRNA	AK057917.1	None
mRNA	AK095828.1	None
mRNA	AK123259.1	BAG53884.1
mRNA	AK126664.1	BAG54353.1
mRNA	AK295144.1	BAG58163.1
mRNA	AK296211.1	BAG58937.1
mRNA	AK314622.1	BAG37188.1
mRNA	BC007418.2	AAH07418.2
mRNA	BC007447.2	AAH07447.2
mRNA	BC029370.1	AAH29370.1
mRNA	BC070064.1	AAH70064.1
mRNA	DB061156.1	None
mRNA	DB069894.1	None
mRNA	DC339431.1	None
mRNA	EL736930.1	None