Format

Send to:

Choose Destination

THOC1 THO complex 1 [ Homo sapiens (human) ]

Gene ID: 9984, updated on 8-May-2016
Official Symbol
THOC1provided by HGNC
Official Full Name
THO complex 1provided by HGNC
Primary source
HGNC:HGNC:19070
See related
Ensembl:ENSG00000079134 HPRD:09498; MIM:606930; Vega:OTTHUMG00000178051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P84; HPR1; P84N5
Summary
HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]
Orthologs
Location:
18p11.32
Exon count:
23
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (214520..268059, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (214520..268059, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371951 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene collectin subfamily member 12 Neighboring gene uncharacterized LOC105376854

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
NHGRI GWA Catalog
  • Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem (from REACTOME)
    Cleavage of Growing Transcript in the Termination Region, organism-specific biosystemThis section includes the cleavage of both polyadenylated and non-polyadenylated transcripts. In the former case polyadenylation has to precede transcript cleavage, while in the latter case there is ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
    RNA Polymerase II Transcription, organism-specific biosystem
    RNA Polymerase II Transcription
  • RNA Polymerase II Transcription Termination, organism-specific biosystem (from REACTOME)
    RNA Polymerase II Transcription Termination, organism-specific biosystemThe detailed annotation of this section will be completed in the next release.
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • THC complex, organism-specific biosystem (from KEGG)
    THC complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • THC complex, conserved biosystem (from KEGG)
    THC complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
  • TREX complex, organism-specific biosystem (from KEGG)
    TREX complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • TREX complex, conserved biosystem (from KEGG)
    TREX complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
  • Transport of Mature Transcript to Cytoplasm, organism-specific biosystem (from REACTOME)
    Transport of Mature Transcript to Cytoplasm, organism-specific biosystemTransport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. The separation of the two compartments and the regulation of this tran...
  • Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing. This coupling is achieved by the nuclear p...
  • mRNA 3'-end processing, organism-specific biosystem (from REACTOME)
    mRNA 3'-end processing, organism-specific biosystemThe 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus TAS
Traceable Author Statement
more info
 
RNA processing TAS
Traceable Author Statement
more info
PubMed 
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
negative regulation of DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of isotype switching to IgA isotypes ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA-templated transcription, elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA-templated transcription, elongation IDA
Inferred from Direct Assay
more info
PubMed 
replication fork processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
 
viral mRNA export from host cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
THO complex IDA
Inferred from Direct Assay
more info
PubMed 
THO complex part of transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
colocalizes_with nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
THO complex subunit 1
Names
hTREX84
nuclear matrix protein p84
tho1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005131.2NP_005122.2  THO complex subunit 1

    See identical proteins and their annotated locations for NP_005122.2

    Status: VALIDATED

    Source sequence(s)
    AK225709, AP000845, BC010381, DA902294
    Consensus CDS
    CCDS45820.1
    UniProtKB/Swiss-Prot
    Q96FV9
    Related
    ENSP00000261600, OTTHUMP00000258403, ENST00000261600, OTTHUMT00000440348
    Conserved Domains (2) summary
    pfam11957
    Location:70541
    efThoc1; THO complex subunit 1 transcription elongation factor
    cd08318
    Location:565650
    Death_NMPP84; Death domain of Nuclear Matrix Protein P84

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

    Range
    214520..268059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525772.1XP_011524074.1  

    Conserved Domains (2) summary
    pfam11957
    Location:70548
    efThoc1; THO complex subunit 1 transcription elongation factor
    cd08318
    Location:572657
    Death_NMPP84; Death domain of Nuclear Matrix Protein P84
  2. XM_011525773.1XP_011524075.1  

    Conserved Domains (2) summary
    pfam11957
    Location:1410
    efThoc1; THO complex subunit 1 transcription elongation factor
    cd08318
    Location:434519
    Death_NMPP84; Death domain of Nuclear Matrix Protein P84
  3. XM_011525774.1XP_011524076.1  

    Conserved Domains (2) summary
    pfam11957
    Location:1241
    efThoc1; THO complex subunit 1 transcription elongation factor
    cd08318
    Location:265350
    Death_NMPP84; Death domain of Nuclear Matrix Protein P84

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    213796..267049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)