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    RBX1 ring-box 1, E3 ubiquitin protein ligase [ Homo sapiens ]

    Gene ID: 9978, updated on 19-May-2012
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    Summary

    Official Symbol
    RBX1provided by HGNC
    Official Full Name
    ring-box 1, E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:9928
    Locus tag
    RP11-554C12.1
    See related
    Ensembl:ENSG00000100387; HPRD:06794; MIM:603814; Vega:OTTHUMG00000151298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ROC1; RNF75; BA554C12.1; MGC1481; FLJ60363; MGC13357
    Summary
    This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]
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    Genomic context

    Location :
    22q13.2
    Sequence :
    Chromosome: 22; NC_000022.10 (41347351..41369019)
    See RBX1 in Epigenomics, MapViewer

    Chromosome 22 - NC_000022.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100652788 Neighboring gene suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) Neighboring gene X-prolyl aminopeptidase (aminopeptidase P) 3, putative Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 7 Neighboring gene actin, gamma 2, smooth muscle, enteric pseudogene Neighboring gene ribosomal protein S9 pseudogene 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity. Kassmeier MD, et al. EMBO J, 2011 Dec 13. PMID 22157821.
    2. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    3. The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation. Fischer ES, et al. Cell, 2011 Nov 23. PMID 22118460.
    4. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (117) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the SCF complex (Skp1/Cul1/F-box protein/Roc1) intervenes in the surveillance of Cdh1 cellular abundance in S-phase
      Title: Involvement of the SCF complex in the control of Cdh1 degradation in S-phase.
    2. Results indicate that FBW5-DDB1-CUL4-ROC1 is an E3 ubiquitin ligase regulating TSC2 protein stability and TSC complex turnover.
      Title: WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.
    3. Data show that REDD1 is subject to ubiquitin-mediated degradation mediated by the CUL4A-DDB1-ROC1-beta-TRCP E3 ligase complex and through the activity of glycogen synthase kinase 3beta.
      Title: REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase.
    4. KLHL20-Cul3-ROC1 is an E3 ligase for DAPK ubiquitination
      Title: The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.
    5. A new conformation of RBX1 involved in the e2-to-substrate ubiquitin-like protein transfer is discussed.
      Title: A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.
    6. ROC1 expression is negatively correlated with cyclin D1 expression, demonstrating its importance in the degradation of cyclin D1 in melanomas.
      Title: Role of ROC1 protein in the control of cyclin D1 protein expression in skin melanomas.
    7. in human cancer cells, RBX1 silencing causes the accumulation of DNA replication licensing proteins CDT1 and ORC1, leading to DNA double-strand breaks, DDR, G(2) arrest, and, eventually, aneuploidy
      Title: RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins.
    8. Data show that CRN7 interacted with Cullin1 and Roc1 to form a novel SCF-like E3 complex.
      Title: Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob.
    9. Nrf2 regulates Cul3-Rbx1 by controlling regulation of expression and induction of Cul3-Rbx1
      Title: An autoregulatory loop between Nrf2 and Cul3-Rbx1 controls their cellular abundance.
    10. The data suggest that RBX1 could potentially be developed into biomarkers of resistance to acyl sulfonamide-based cancer drugs. This will require clinical validation in a series of patients treated with R3200.
      Title: Candidate biomarkers of response to an experimental cancer drug identified through a large-scale RNA interference genetic screen.
    Submit: New GeneRIF Correction See all (20)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif (amino acids 144-149; SLQXLA motif) interacts with cellular proteins Cul5, elongins B and C, and Rbx1 to form an Skp1-cullin-F-box (SCF)-like complex that allows Vif to interact with APOBEC3G and induce its ubiquitination and degradation PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_055063.1 NP_003583.2 CUL1    BIND  PubMed CUL1 interacts with ROC1. 
    NP_055063.1 NP_003583.2 CUL1    BIND  PubMed Rbx1 interacts with Cul1 [411-776] to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex. 
    NP_055063.1 NP_003580.1 CUL4A    BIND  PubMed ROC1 interacts with Cul4A. 
    NP_055063.1 NP_003469.2 CUL5    BIND  PubMed Rbx1 interacts with Cul5. 
    P62877 Q86VP6 CAND1    HPRD  PubMed  
    P62877 P24385 CCND1    HPRD  PubMed  
    P62877 Q7L5N1 COPS6    HPRD  PubMed  
    P62877 Q13616 CUL1    HPRD  PubMed  
    P62877 Q13618 CUL3    HPRD  PubMed  
    P62877 Q13620 CUL4B    HPRD  PubMed  
    P62877 Q93034 CUL5    HPRD  PubMed  
    P62877 Q14999 CUL7    HPRD  PubMed  
    P62877 Q8NFZ0 FBXO18    HPRD  PubMed  
    P62877 Q8N3Y1 FBXW8    HPRD  PubMed  
    P62877 Q13098 GPS1    HPRD  PubMed  
    P62877 P63208 SKP1    HPRD  PubMed  
    P62877 P84022 SMAD3    HPRD  PubMed  
    P62877 P40337 VHL    HPRD  PubMed  
    BioGRID:115301 BioGRID:117367 ABTB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:106586 ACTG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115301 BioGRID:121559 ARID1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:107068 BCL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:120937 CAND1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:115301 BioGRID:107286 CASP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:107067 CCND1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:107334 CCND2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:107336 CCND3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:107432 CDC34    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115301 BioGRID:122728 CORO7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:119360 CRBN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:107838 CSNK1E    BioGRID  PubMed Two-hybrid 
    BioGRID:115301 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Reconstituted Complex; Two-hybrid 
    BioGRID:115301 BioGRID:114031 CUL2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:115301 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:115301 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:115301 BioGRID:114028 CUL4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115301 BioGRID:113743 CUL5    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Two-hybrid 
    BioGRID:115301 BioGRID:115159 CUL7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115301 BioGRID:119920 DCUN1D1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115301 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
    BioGRID:115301 BioGRID:108010 DDB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:120387 DET1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:108078 DIO2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:108201 E2F1    BioGRID  PubMed Biochemical Activity 
    BioGRID:115301 BioGRID:114079 ENC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:123173 FBXO11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:124333 FBXO18    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115301 BioGRID:117649 FBXO22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115301 BioGRID:117657 FBXO3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115301 BioGRID:122890 FBXO31    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:119962 FBXO42    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:116887 FBXW11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:117645 FBXW8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:108765 FRZB    BioGRID  PubMed Two-hybrid 
    BioGRID:115301 BioGRID:113800 GAN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:109535 HSPA1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115301 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115301 BioGRID:120041 ING3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:115607 KBTBD10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:115156 KEAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:112748 MAP3K7    BioGRID  PubMed Two-hybrid 
    BioGRID:115301 BioGRID:117086 MAPK8IP2    BioGRID  PubMed Two-hybrid 
    BioGRID:115301 BioGRID:125219 MED8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:113841 NCOA3    BioGRID  PubMed Biochemical Activity 
    BioGRID:115301 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115301 BioGRID:128154 PGAM5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:111660 PSMA6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:111715 PTGS2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:111832 RAG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:122136 RFWD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:128962 RICTOR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:112112 RPS6KB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115301 BioGRID:249866 Rps6kb1    BioGRID  PubMed Two-hybrid 
    BioGRID:115301 BioGRID:112391 SKP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115301 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115301 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:115301 BioGRID:115717 TAB1    BioGRID  PubMed Two-hybrid 
    BioGRID:115301 BioGRID:112783 TCEB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:112785 TCEB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:117569 TRPC4AP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:115651 TUBA1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115301 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115301 BioGRID:117507 UBXN7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115301 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:115301 BioGRID:115079 VPRBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115301 BioGRID:119725 ZAK    BioGRID  PubMed Two-hybrid 
    BioGRID:115301 BioGRID:119592 ZC3HC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:1205537 gag    BioGRID  PubMed Co-purification 
    BioGRID:115301 BioGRID:592682 skp2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115301 BioGRID:1205539 vif    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Circadian rhythm - mammal, organism-specific biosystem (from KEGG)
      Circadian rhythm - mammal, organism-specific biosystem
      Circadian rhythm - mammal
    • Circadian rhythm - mammal, conserved biosystem (from KEGG)
      Circadian rhythm - mammal, conserved biosystem
      Circadian rhythm - mammal
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Cul3-SPOP complex, organism-specific biosystem (from KEGG)
      Cul3-SPOP complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • Cul4-DDB1-CSA complex, organism-specific biosystem (from KEGG)
      Cul4-DDB1-CSA complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • Cul4-DDB1-DDB2 complex, organism-specific biosystem (from KEGG)
      Cul4-DDB1-DDB2 complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • ECV complex, organism-specific biosystem (from KEGG)
      ECV complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem (from Pathway Interaction Database)
      Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem
      Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
    • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
      NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
    • Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Nuclear signaling by ERBB4, organism-specific biosystemBesides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A CYT2) undergo proteolytic cleavage by ADAM17 (TACE) in the juxtamembr...
    • Nucleotide excision repair, organism-specific biosystem (from KEGG)
      Nucleotide excision repair, organism-specific biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
    • Nucleotide excision repair, conserved biosystem (from KEGG)
      Nucleotide excision repair, conserved biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Prolactin receptor signaling, organism-specific biosystem (from REACTOME)
      Prolactin receptor signaling, organism-specific biosystemProlactin (PRL) is a hormone secreted mainly by the anterior pituitary gland. It was originally identified by its ability to stimulate the development of the mammary gland and lactation, but is now k...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • SCF-BTRC complex, organism-specific biosystem (from KEGG)
      SCF-BTRC complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-FBS complex, organism-specific biosystem (from KEGG)
      SCF-FBS complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-FBS complex, conserved biosystem (from KEGG)
      SCF-FBS complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-FBW7 complex, organism-specific biosystem (from KEGG)
      SCF-FBW7 complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-SKP2 complex, organism-specific biosystem (from KEGG)
      SCF-SKP2 complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Vif-mediated degradation of APOBEC3G, organism-specific biosystem (from REACTOME)
      Vif-mediated degradation of APOBEC3G, organism-specific biosystemThe HIV-1 accessory protein Vif (Viral infectivity factor) is required for the efficient infection of primary cell populations (e.g., lymphocytes and macrophages) and ââ?¬Å?non-permissiveââ?¬Â? cel...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NEDD8 ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		  
    protein neddylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    viral reproduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Cul4A-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Cul4B-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    VCB complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RBX1
    Names
    E3 ubiquitin-protein ligase RBX1
    ZYP protein
    RING box protein 1
    RING-box protein 1
    RING finger protein 75
    regulator of cullins 1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014248.3 → NP_055063.1  E3 ubiquitin-protein ligase RBX1

      Status: REVIEWED

      Source sequence(s)
      AF140598, DA353856, DN602016
      Consensus CDS
      CCDS14009.1
      UniProtKB/Swiss-Prot
      P62877
      Related
      ENSP00000216225, OTTHUMP00000199764, ENST00000216225, OTTHUMT00000322149
      Conserved Domains (1) summary
      cl15348
      Location:20 – 108
      Blast Score: 326
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000022.10 Reference GRCh37.p5 Primary Assembly

      Range
      41347351..41369019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000154.1 Alternate HuRef

      Range
      24308951..24330592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL080242.11 CAB62925.1
    genomic CH471095.1 EAW60402.1
      EAW60403.1
    genomic GM863522.1 CAT16469.1
    mRNA AF085906.1 None
    mRNA AF140598.1 AAD29715.1
    mRNA AF142059.1 AAD30146.1
    mRNA AK090764.1 None
    mRNA AK315722.1 BAG38078.1
    mRNA AY099360.1 AAM21718.1
    mRNA BC001466.2 AAH01466.1
    mRNA BC017370.1 AAH17370.2
    mRNA CR456560.1 CAG30446.1
    mRNA DA353856.1 None
    mRNA DN602016.1 None
    other-genetic CU013160.1 CAK54591.1
    other-genetic CU013448.1 CAK54890.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62877.1 GenPept UniProtKB/Swiss-Prot:P62877
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
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