Display Settings:

Format

Send to:

Choose Destination

NUP153 nucleoporin 153kDa [ Homo sapiens (human) ]

Gene ID: 9972, updated on 27-Sep-2014
Official Symbol
NUP153provided by HGNC
Official Full Name
nucleoporin 153kDaprovided by HGNC
Primary source
HGNC:HGNC:8062
See related
Ensembl:ENSG00000124789; HPRD:04899; MIM:603948; Vega:OTTHUMG00000014312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
N153; HNUP153
Summary
Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
See NUP153 in Epigenomics, MapViewer
Location:
6p22.3
Exon count:
24
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (17615035..17706834, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (17615266..17707065, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724591 Neighboring gene family with sequence similarity 8, member A1 Neighboring gene RNA, 5S ribosomal pseudogene 204 Neighboring gene kinesin family member 13A Neighboring gene ribosomal protein S12 pseudogene 12

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Depletion of nucleoporin 153kDa (NUP153) by shRNA inhibits HIV-1 infection in human Jurkat lymphocytes PubMed
Knockdown of nucleoporin 153kDa (NUP153) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of nucleoporin 153kDa (NUP153) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev antibodies to nup153 can block the nuclear export of Rev as well as Rev-dependent RNA export PubMed
rev nup153 is involved in Rev-mediated nuclear export of HIV-1 mRNA through an interaction with eukaryotic initiation factor 5A (eIF-5A) which binds to Rev PubMed
Tat tat Interaction of HIV-1 Tat with Nup153 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
Vpr vpr HIV-1 Vpr co-immunoprecipitates in vitro-translated human Nup153 PubMed
capsid gag Nucleoporins NUP153 and NUP98 bind in vitro assembled HIV-1 CA-NC complexes, suggesting that both nucleoporins bind the HIV-1 core during the early stages of infection PubMed
gag HIV-1 CA mutant N74D and depletion of NUP153 and LEDGF/p75 significantly reduce HIV-1 DNA integration into gene-rich regions of chromosomes and gene bodies PubMed
gag NUP153 dependency during HIV-1 infection is dependent on HIV-1 CA PubMed
integrase gag-pol NUP153 dependency during HIV-1 infection is dependent on HIV-1 integrase (IN) PubMed
gag-pol NTF2 is enriched at the nuclear envelope and interacts with NUP153, When added in excess to the import assay, NUP153C inhibited the nuclear import of IN. PubMed
gag-pol HIV-1 IN binds directly to nucleoporin NUP153 in cells. The binding involves the C-terminal FxFG-rich region of NUP153 PubMed
nucleocapsid gag Nucleoporins NUP153 and NUP98 bind in vitro assembled HIV-1 CA-NC complexes, suggesting that both nucleoporins bind the HIV-1 core during the early stages of infection PubMed

Go to the HIV-1, Human Interaction Database

  • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
    Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystem (from REACTOME)
    Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystemInfluenza genomic RNA (vRNA), synthesized in the nucleus of the infected host cell, is packaged into ribonucleoprotein (RNP) complexes containing viral polymerase proteins and NP (nucleocapsid). NP ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Glucose transport, organism-specific biosystem (from REACTOME)
    Glucose transport, organism-specific biosystemCells take up glucose by facilitated diffusion, via glucose transporters (GLUTs) associated with the plasma membrane, a reversible reaction (Joost and Thorens 2001). Four tissue-specific GLUT isoform...
  • Glycogen storage diseases, organism-specific biosystem (from REACTOME)
    Glycogen storage diseases, organism-specific biosystemThe regulated turnover of glycogen plays a central, tissue-specific role in the maintenance of blood glucose levels and in the provision of glucose to tissues such as muscle and brain in response to ...
  • HIV Infection, organism-specific biosystem (from REACTOME)
    HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
  • HIV Life Cycle, organism-specific biosystem (from REACTOME)
    HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
  • Hexose transport, organism-specific biosystem (from REACTOME)
    Hexose transport, organism-specific biosystemHexoses, notably fructose, glucose, and galactose, generated in the lumen of the small intestine by breakdown of dietary carbohydrate are taken up by enterocytes lining the microvilli of the small in...
  • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
    Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
  • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
    ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Influenza Infection, organism-specific biosystem (from REACTOME)
    Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
  • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
    Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
  • Interactions of Rev with host cellular proteins, organism-specific biosystem (from REACTOME)
    Interactions of Rev with host cellular proteins, organism-specific biosystemIn order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nucl...
  • Interactions of Vpr with host cellular proteins, organism-specific biosystem (from REACTOME)
    Interactions of Vpr with host cellular proteins, organism-specific biosystemVpr has been implicated in multiple processes during HIV-1 replication, including nuclear import of the pre-integration complex (PIC)(Heinzinger et al., 1994), apoptosis (Stewart et al., 1997) and in...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
    Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Metabolism of non-coding RNA, organism-specific biosystem (from REACTOME)
    Metabolism of non-coding RNA, organism-specific biosystemThe term non-coding is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. There is considerable evidence tha...
  • Mitotic Prophase, organism-specific biosystem (from REACTOME)
    Mitotic Prophase, organism-specific biosystemDuring prophase, the chromatin in the nucleus condenses, and the nucleolus disappears. Centrioles begin moving to the opposite poles or sides of the cell. Some of the fibers that extend from the cen...
  • Myoclonic epilepsy of Lafora, organism-specific biosystem (from REACTOME)
    Myoclonic epilepsy of Lafora, organism-specific biosystemLafora disease is a progressive neurodegenerative disorder with onset typically late in childhood, characterized by seizures and progressive neurological deterioration and death within ten years of o...
  • NEP/NS2 Interacts with the Cellular Export Machinery, organism-specific biosystem (from REACTOME)
    NEP/NS2 Interacts with the Cellular Export Machinery, organism-specific biosystemThe viral RNP complex is exported from the nucleus via the host cell CRM1 export pathway (Fukuda, 1997; Neumann, 2000; reviewed in Buolo, 2006). The vRNP complex does not interact directly with CRM1 ...
  • Nuclear Envelope Breakdown, organism-specific biosystem (from REACTOME)
    Nuclear Envelope Breakdown, organism-specific biosystemThe nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelo...
  • Nuclear Pore Complex (NPC) Disassembly, organism-specific biosystem (from REACTOME)
    Nuclear Pore Complex (NPC) Disassembly, organism-specific biosystemNuclear envelope breakdown in mitosis involves permeabilization of the nuclear envelope through disassembly of the nuclear pore complex (NPC) (reviewed by Guttinger et al. 2009). Nucleoporin NUP98, l...
  • Nuclear import of Rev protein, organism-specific biosystem (from REACTOME)
    Nuclear import of Rev protein, organism-specific biosystemNuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev pr...
  • Nuclear pore complex, organism-specific biosystem (from KEGG)
    Nuclear pore complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • Nuclear pore complex, conserved biosystem (from KEGG)
    Nuclear pore complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Regulation of Glucokinase by Glucokinase Regulatory Protein, organism-specific biosystem (from REACTOME)
    Regulation of Glucokinase by Glucokinase Regulatory Protein, organism-specific biosystemGlucokinase (GCK1) is negatively regulated by glucokinase regulatory protein (GKRP), which reversibly binds the enzyme to form an inactive complex. Binding is stimulated by fructose 6-phosphate and s...
  • Regulation of cytoplasmic and nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling, organism-specific biosystem
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling
  • Rev-mediated nuclear export of HIV RNA, organism-specific biosystem (from REACTOME)
    Rev-mediated nuclear export of HIV RNA, organism-specific biosystemThe HIV-1 genome contains 9 genes encoded by a single transcript. In order for the virus to replicate, unspliced, singly-spliced and fully spliced viral mRNA must be exported from the nucleus. The H...
  • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
    SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
  • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transport of Mature Transcript to Cytoplasm, organism-specific biosystem (from REACTOME)
    Transport of Mature Transcript to Cytoplasm, organism-specific biosystemTransport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. The separation of the two compartments and the regulation of this tran...
  • Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing.
  • Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing. This coupling is achieved by the nuclear p...
  • Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystemTransport of mature mRNAs derived from intronless transcripts require some of the same protein complexes as mRNAs derived from intron containing complexes, including TAP and Aly/Ref. However a number...
  • Transport of Ribonucleoproteins into the Host Nucleus, organism-specific biosystem (from REACTOME)
    Transport of Ribonucleoproteins into the Host Nucleus, organism-specific biosystemAn unusual characteristic of the influenza virus life cycle is its dependence on the nucleus. Trafficking of the viral genome into and out of the nucleus is a tightly regulated process with all viral...
  • Transport of the SLBP Dependant Mature mRNA, organism-specific biosystem (from REACTOME)
    Transport of the SLBP Dependant Mature mRNA, organism-specific biosystemTransport of U7 snRNP and stem-loop binding protein (SLBP) processed mRNA.
  • Transport of the SLBP independent Mature mRNA, organism-specific biosystem (from REACTOME)
    Transport of the SLBP independent Mature mRNA, organism-specific biosystemTransport of the SLBP independent Mature mRNA through the nuclear pore.
  • Vpr-mediated nuclear import of PICs, organism-specific biosystem (from REACTOME)
    Vpr-mediated nuclear import of PICs, organism-specific biosystemVpr appears to function in anchoring the PIC to the nuclear envelope. This anchoring likely involves interactions between Vpr and host nucleoporins.
  • snRNP Assembly, organism-specific biosystem (from REACTOME)
    snRNP Assembly, organism-specific biosystemSmall nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
 
nucleocytoplasmic transporter activity IDA
Inferred from Direct Assay
more info
 
protein anchor IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of nuclear pore IMP
Inferred from Mutant Phenotype
more info
PubMed 
transporter activity TAS
Traceable Author Statement
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
glucose transport TAS
Traceable Author Statement
more info
 
hexose transport TAS
Traceable Author Statement
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
mitotic nuclear envelope disassembly TAS
Traceable Author Statement
more info
 
negative regulation of RNA export from nucleus IDA
Inferred from Direct Assay
more info
 
nuclear pore complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of glucose transport TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
viral penetration into host nucleus IEA
Inferred from Electronic Annotation
more info
 
viral process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nuclear inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore nuclear basket IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
nuclear pore complex protein Nup153
Names
nuclear pore complex protein Nup153
nucleoporin 153kD
nucleoporin Nup153
153 kDa nucleoporin
nuclear pore complex protein hnup153

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278209.1NP_001265138.1  nuclear pore complex protein Nup153 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB210024, AI948895, AK295644, AL597150, BC052965, CB217525
    Consensus CDS
    CCDS64359.1
    UniProtKB/Swiss-Prot
    P49790
    Related
    ENSP00000444029, ENST00000537253
    Conserved Domains (3) summary
    pfam00641
    Location:754781
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam08604
    Location:113665
    Nup153; Nucleoporin Nup153-like
    pfam10599
    Location:14171506
    Nup_retrotrp_bd; Retro-transposon transporting motif
  2. NM_001278210.1NP_001265139.1  nuclear pore complex protein Nup153 isoform 3

    See proteins identical to NP_001265139.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.
    Source sequence(s)
    AB210024, AI948895, AL597150, CB217525, DA856239
    Consensus CDS
    CCDS75407.1
    UniProtKB/Swiss-Prot
    P49790
    Related
    ENSP00000478627, ENST00000613258
    Conserved Domains (3) summary
    pfam00641
    Location:681708
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam08604
    Location:113573
    Nup153; Nucleoporin Nup153-like
    pfam10599
    Location:13441433
    Nup_retrotrp_bd; Retro-transposon transporting motif
  3. NM_005124.3NP_005115.2  nuclear pore complex protein Nup153 isoform 2

    See proteins identical to NP_005115.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AB210024, AI948895, AL597150, BC052965, CB217525
    Consensus CDS
    CCDS4541.1
    UniProtKB/Swiss-Prot
    P49790
    Related
    ENSP00000262077, OTTHUMP00000016070, ENST00000262077, OTTHUMT00000039953
    Conserved Domains (3) summary
    pfam00641
    Location:723750
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam08604
    Location:113634
    Nup153; Nucleoporin Nup153-like
    pfam10599
    Location:13861475
    Nup_retrotrp_bd; Retro-transposon transporting motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    17615035..17706834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249507.1XP_005249564.1  

    Conserved Domains (3) summary
    pfam00641
    Location:705732
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam08604
    Location:113616
    Nup153; Nucleoporin Nup153-like
    pfam10599
    Location:13681457
    Nup_retrotrp_bd; Retro-transposon transporting motif
  2. XM_006715290.1XP_006715353.1  

    Conserved Domains (3) summary
    pfam00641
    Location:717744
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam08604
    Location:113628
    Nup153; Nucleoporin Nup153-like
    pfam10599
    Location:13801469
    Nup_retrotrp_bd; Retro-transposon transporting motif
  3. XM_006715291.1XP_006715354.1  

    Conserved Domains (2) summary
    pfam00641
    Location:723750
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam08604
    Location:113634
    Nup153; Nucleoporin Nup153-like

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    17559859..17651999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    17617771..17709603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)