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MED13 mediator complex subunit 13 [ Homo sapiens (human) ]

Gene ID: 9969, updated on 8-May-2016
Official Symbol
MED13provided by HGNC
Official Full Name
mediator complex subunit 13provided by HGNC
Primary source
HGNC:HGNC:22474
See related
Ensembl:ENSG00000108510 HPRD:07229; MIM:603808; Vega:OTTHUMG00000179251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC250; THRAP1; DRIP250; HSPC221; TRAP240
Summary
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]
Orthologs
Location:
17q23.2
Exon count:
32
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (61942605..62065311, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (60019966..60142643, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene BRCA1 interacting protein C-terminal helicase 1 Neighboring gene uncharacterized LOC105371851 Neighboring gene integrator complex subunit 2 Neighboring gene uncharacterized LOC105371852 Neighboring gene polymerase (RNA) mitochondrial pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic determinants of P wave duration and PR segment.
NHGRI GWA Catalog
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0593

Gene Ontology Provided by GOA

Component Evidence Code Pubs
mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
mediator of RNA polymerase II transcription subunit 13
Names
activator-recruited cofactor 250 kDa component
mediator of RNA polymerase II transcription, subunit 13 homolog
thyroid hormone receptor associated protein 1
thyroid hormone receptor-associated protein 1
thyroid hormone receptor-associated protein complex 240 kDa component
thyroid hormone receptor-associated protein complex component TRAP240
thyroid hormone receptor-associated protein, 240 kDa subunit
vitamin D3 receptor-interacting protein complex component DRIP250

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046948.1 RefSeqGene

    Range
    5030..127707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005121.2NP_005112.2  mediator of RNA polymerase II transcription subunit 13

    See identical proteins and their annotated locations for NP_005112.2

    Status: REVIEWED

    Source sequence(s)
    AB011165, AC060798, AF117754, BP332524, BQ709424, CN273870
    Consensus CDS
    CCDS42366.1
    UniProtKB/Swiss-Prot
    Q9UHV7
    UniProtKB/TrEMBL
    A0A024QZ75
    Related
    ENSP00000380888, OTTHUMP00000261005, ENST00000397786, OTTHUMT00000445461
    Conserved Domains (2) summary
    pfam06333
    Location:16402165
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam11597
    Location:14384
    Med13_N; Mediator complex subunit 13 N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    61942605..62065311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525551.1XP_011523853.1  

    Conserved Domains (2) summary
    pfam06333
    Location:16402112
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam11597
    Location:14384
    Med13_N; Mediator complex subunit 13 N-terminal
  2. XM_011525553.1XP_011523855.1  

    Conserved Domains (2) summary
    pfam06333
    Location:14171942
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam11597
    Location:35161
    Med13_N; Mediator complex subunit 13 N-terminal
  3. XM_011525554.1XP_011523856.1  

    Conserved Domains (1) summary
    pfam06333
    Location:8631388
    Med13_C; Mediator complex subunit 13 C-terminal
  4. XM_011525552.1XP_011523854.1  

    Conserved Domains (2) summary
    pfam06333
    Location:16401990
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam11597
    Location:14384
    Med13_N; Mediator complex subunit 13 N-terminal

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    60084531..60207191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)