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THRAP3 thyroid hormone receptor associated protein 3 [ Homo sapiens (human) ]

Gene ID: 9967, updated on 15-May-2016
Official Symbol
THRAP3provided by HGNC
Official Full Name
thyroid hormone receptor associated protein 3provided by HGNC
Primary source
HGNC:HGNC:22964
See related
Ensembl:ENSG00000054118 HPRD:07543; MIM:603809; Vega:OTTHUMG00000007866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRAP150
Orthologs
Location:
1p34.3
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (36224416..36305357)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36690017..36770958)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene collagen type VIII alpha 2 Neighboring gene trafficking protein particle complex 3 Neighboring gene MAP7 domain containing 1 Neighboring gene SH3 domain containing 21 Neighboring gene eva-1 homolog B (C. elegans)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with thyroid hormone receptor associated protein 3 (THRAP3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies transcription regulatory and chromatin remodeling factors LEDGF/p75, KAP1, BTF3b, THRAP3, and HMGN2 as IN-binding partners PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human thyroid hormone receptor associated protein 3 (THRAP3) at amino acid residues 473-474 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22082, MGC133082, MGC133083

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription cofactor activity IDA
Inferred from Direct Assay
more info
PubMed 
core promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ligand-dependent nuclear receptor transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
phosphoprotein binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription cofactor activity IDA
Inferred from Direct Assay
more info
PubMed 
vitamin D receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with exon-exon junction complex IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
thyroid hormone receptor-associated protein 3
Names
thyroid hormone receptor-associated protein complex 150 kDa component
thyroid hormone receptor-associated protein, 150 kDa subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321471.1NP_001308400.1  thyroid hormone receptor-associated protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC114484, AI754117, AK025735, BC112350, HY001123
    Conserved Domains (1) summary
    pfam15440
    Location:194810
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
  2. NM_001321473.1NP_001308402.1  thyroid hormone receptor-associated protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI754117, AK025735, BC112330, HY001123
    Conserved Domains (1) summary
    pfam15440
    Location:194810
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
  3. NM_005119.3NP_005110.2  thyroid hormone receptor-associated protein 3 isoform 1

    See identical proteins and their annotated locations for NP_005110.2

    Status: VALIDATED

    Source sequence(s)
    AI754117, AK025735, BC112350, BG572651
    Consensus CDS
    CCDS405.1
    UniProtKB/Swiss-Prot
    Q9Y2W1
    Related
    ENSP00000346634, OTTHUMP00000009597, ENST00000354618, OTTHUMT00000021688
    Conserved Domains (1) summary
    pfam15440
    Location:194810
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    36224416..36305357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271371.3XP_005271428.1  

    Conserved Domains (1) summary
    pfam15440
    Location:2423
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

RNA

  1. XR_246308.3 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    36806468..36887127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)