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    CDC27 cell division cycle 27 homolog (S. cerevisiae) [ Homo sapiens ]

    Gene ID: 996, updated on 12-May-2012
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    Summary

    Official Symbol
    CDC27provided by HGNC
    Official Full Name
    cell division cycle 27 homolog (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:1728
    See related
    Ensembl:ENSG00000004897; HPRD:00304; MIM:116946; Vega:OTTHUMG00000166429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APC3; HNUC; NUC2; ANAPC3; CDC27Hs; D0S1430E; D17S978E
    Summary
    The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    17q21.32
    Sequence :
    Chromosome: 17; NC_000017.10 (45195310..45266665, complement)
    See CDC27 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37A pseudogene Neighboring gene uncharacterized LOC100506214 Neighboring gene putative uncharacterized protein C14orf165-like Neighboring gene ribosomal protein S2 pseudogene 47 Neighboring gene myosin, light chain 4, alkali; atrial, embryonic Neighboring gene integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Neighboring gene uncharacterized LOC100506252

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. Lara-Gonzalez P, et al. J Cell Sci, 2011 Dec 15. PMID 22193957.
    2. Molecular basis for the association of microcephalin (MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the anaphase-promoting complex. Singh N, et al. J Biol Chem, 2012 Jan 20. PMID 22139841.
    3. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (84) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the biochemical, structural, and cellular determinants of the novel interaction between MCPH1 and Cdc27 and suggest that this interaction may occur within the larger context of MCPH1-APC/C.
      Title: Molecular basis for the association of microcephalin (MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the anaphase-promoting complex.
    2. phosphorylation of Cdc27 by CKII is involved in TGF-beta-induced activation of APC.
      Title: Phosphorylation of the anaphase-promoting complex/Cdc27 is involved in TGF-beta signaling.
    3. Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
      Title: How APC/C-Cdc20 changes its substrate specificity in mitosis.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
    5. The interaction is direct and is mediated by the tandem BRCA1 C-terminal domains of MDC1 and the C terminus of the Cdc27 (APC3) subunit of the anaphase-promoting complex/cyclosome.
      Title: The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome.
    6. the spindle checkpoint may regulate CDC27/APC activity at mitosis
      Title: The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis.
    7. HOXC10 co-immunoprecipitates the APC subunit CDC27, and its in vitro degradation is reduced in APC-depleted extracts or by competition with the APC substrate cyclin A.
      Title: Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001247.2 NP_057347.2 FZR1    BIND  PubMed Cdh1 interacts with Cdc27. 
    NP_001247.2 NP_006212.1 PIN1    BIND  PubMed Pin1 interacts with Cdc27. 
    P30260 Q9UM13 ANAPC10    HPRD  PubMed  
    P30260 Q9UJX6 ANAPC2    HPRD  PubMed  
    P30260 Q9UJX3 ANAPC7    HPRD  PubMed  
    P30260 O60566 BUB1B    HPRD  PubMed  
    P30260 P42574 CASP3    HPRD  PubMed  
    P30260 Q13042 CDC16    HPRD  PubMed  
    P30260 Q12834 CDC20    HPRD  PubMed  
    P30260 Q8NHZ8 CDC26    HPRD  PubMed  
    P30260 Q9UM11 FZR1    HPRD  PubMed  
    P30260 Q9NYD6 HOXC10    HPRD  PubMed  
    P30260 Q13257 MAD2L1    HPRD  PubMed  
    P30260 Q13526 PIN1    HPRD  PubMed  
    P30260 P53041 PPP5C    HPRD  PubMed  
    P30260 P06400 RB1    HPRD  PubMed  
    P30260 P12757 SKIL    HPRD  PubMed  
    P30260 Q15796 SMAD2    HPRD  PubMed  
    P30260 P84022 SMAD3    HPRD  PubMed  
    BioGRID:107431 BioGRID:122229 ANAPC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:107431 BioGRID:115665 ANAPC10    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107431 BioGRID:119591 ANAPC11    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107431 BioGRID:125643 ANAPC16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:118937 ANAPC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:118982 ANAPC4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107431 BioGRID:119537 ANAPC5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107431 BioGRID:119538 ANAPC7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107431 BioGRID:115585 APC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107431 BioGRID:201352 Anapc1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:213171 Anapc13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:206755 Anapc16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:221196 Anapc2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:208479 Anapc5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:107166 BUB1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107431 BioGRID:114621 BUB3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107431 BioGRID:198405 Bub1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:107331 CCNA2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107431 BioGRID:107332 CCNB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107431 BioGRID:114400 CDC16    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:107431 BioGRID:107427 CDC20    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107431 BioGRID:114242 CDC23    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107431 BioGRID:128878 CDC26    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107431 BioGRID:107434 CDH1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107431 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107431 BioGRID:107582 CKS1B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107431 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107431 BioGRID:107880 CTNNB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107431 BioGRID:213776 Cdc16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:223749 Cdc20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:206665 Cdc23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:229869 Cdc27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:198624 Cdk1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:119489 FZR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107431 BioGRID:580243 Gm9174    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:109531 HSF2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107431 BioGRID:110260 MAD2L1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107431 BioGRID:115014 MDC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107431 BioGRID:207818 Mad2l1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:107431 BioGRID:111528 PPP5C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107431 BioGRID:114663 PTTG1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107431 BioGRID:202349 Ppp5c    BioGRID  PubMed Two-hybrid 
    BioGRID:107431 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107431 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107431 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:131991 SPATC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107431 BioGRID:113123 TTK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107431 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107431 BioGRID:118150 UBE2S    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107431 BioGRID:113866 USP11    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the CDC27 gene: The CDC27 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • APC/C complex, organism-specific biosystem (from KEGG)
      APC/C complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • APC/C complex, conserved biosystem (from KEGG)
      APC/C complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
    • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
      APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
    • APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystemThe degradation of cyclin B1, which appears to occur at the mitotic spindle, is delayed until the metaphase /anaphase transition by the spindle assembly checkpoint and is required in order for sister...
    • APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystemThe separation of sister chromatids in anaphase requires the destruction of the anaphase inhibitor, securin. Securin associates with and inactivates the protease, separase. Separase cleaves the cohe...
    • APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemFollowing phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the ...
    • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
      APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemFrom late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Gemin...
    • Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemAPC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein ...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystem (from REACTOME)
      Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystemCdh1 is degraded by the APC/C during in G1 and G0. This auto-regulation may contribute to reducing the levels of Cdh1 levels during G1 and G0 (Listovsky et al., 2004).
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystem (from REACTOME)
      Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystemThe activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inactivation of APC/C via direct inhibition of the APC/C complex, organism-specific biosystem (from REACTOME)
      Inactivation of APC/C via direct inhibition of the APC/C complex, organism-specific biosystemIn the direct inhibition model, the cytosolic Mitotic Checkpoint Complex, consisting of hBUBR1, hBUB3, Cdc20 and Mad2, directly inhibits APC/C by binding to it.
    • Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, organism-specific biosystem (from REACTOME)
      Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, organism-specific biosystemThe target of the mitotic checkpoint is the Anaphase Promoting Complex/Cyclosome (APC/C) an E3 ubiquitin ligase that targets proteins whose destruction is essential for mitotic exit. Currently, there...
    • Mitotic Spindle Checkpoint, organism-specific biosystem (from REACTOME)
      Mitotic Spindle Checkpoint, organism-specific biosystemThe mitotic checkpoint or spindle assembly checkpoint is an evolutionarily conserved mechanism that ensures that cells with misaligned chromosomes do not exit mitosis and divide to form aneuploid cel...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Phosphorylation of the APC/C, organism-specific biosystem (from REACTOME)
      Phosphorylation of the APC/C, organism-specific biosystemPhosphorylation of APC subunits is required for Cdc20 mediated activation by of the APC/C at the metaphase anaphase transition (Kramer et al., 2000). While the kinases responsible for phosphorylation...
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
      Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemThe APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zacha...
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		  
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle spindle assembly checkpoint TAS
    Traceable Author Statement
    more info
    		  
    mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    spindle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    cell division cycle protein 27 homolog
    Names
    cell division cycle protein 27 homolog
    H-NUC
    nuc2 homolog
    CDC27 homolog
    anaphase promoting complex subunit 3
    anaphase-promoting complex subunit 3
    anaphase-promoting complex, protein 3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114091.1 → NP_001107563.1  cell division cycle protein 27 homolog isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC002558, BC011656, BP234964, S78234
      Consensus CDS
      CCDS45720.1
      UniProtKB/TrEMBL
      G3V1C4
      UniProtKB/Swiss-Prot
      P30260
      Related
      ENSP00000434614, OTTHUMP00000232875, ENST00000531206, OTTHUMT00000389745
      Conserved Domains (4) summary
      cd00189
      Location:574 – 673
      Blast Score: 236
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam12895
      Location:17 – 92
      Blast Score: 226
      Apc3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13414
      Location:605 – 672
      Blast Score: 154
      TPR_11; TPR repeat
      pfam13424
      Location:463 – 534
      Blast Score: 98
      TPR_12; Tetratricopeptide repeat

    2. NM_001256.3 → NP_001247.3  cell division cycle protein 27 homolog isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate splice site, as compared to variant 1. The resulting isoform 2 lacks an internal segment and has the same N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      AC002558, BP234964, S78234
      Consensus CDS
      CCDS11509.1
      UniProtKB/Swiss-Prot
      P30260
      Related
      ENSP00000066544, OTTHUMP00000232872, ENST00000066544, OTTHUMT00000389742
      Conserved Domains (4) summary
      cd00189
      Location:568 – 667
      Blast Score: 236
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam12895
      Location:17 – 92
      Blast Score: 225
      Apc3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13414
      Location:599 – 666
      Blast Score: 153
      TPR_11; TPR repeat
      pfam13424
      Location:457 – 528
      Blast Score: 98
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      45195310..45266665, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      40572496..40644750, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC002558.2 (78260..80956) None
    genomic AY518321.1 AAR89911.1
    genomic CH471231.2 EAW57686.1
      EAW57687.1
      EAW57688.1
      EAW57689.1
    mRNA AK296881.1 BAG59442.1
    mRNA AK299342.1 BAG61343.1
    mRNA AU135593.1 None
    mRNA BC011656.2 AAH11656.1
    mRNA BI548077.1 None
    mRNA BP234964.1 None
    mRNA DQ786193.1 None
    mRNA S78234.1 AAB34378.1
    mRNA U00001.1 AAA60471.1
    other-genetic DQ892780.2 ABM83706.1
    other-genetic DQ896027.2 ABM87026.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30260.2 GenPept UniProtKB/Swiss-Prot:P30260
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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