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    Dpyd dihydropyrimidine dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 99586, updated on 18-May-2013
    Official Symbol
    Dpydprovided by MGI
    Official Full Name
    dihydropyrimidine dehydrogenaseprovided by MGI
    Primary source
    MGI:2139667
    See related
    Ensembl:ENSMUSG00000033308; Vega:OTTMUSG00000025956
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DPD; AI315208; E330028L06Rik
    Location :
    3 G1; 3
    Sequence :
    Chromosome: 3; NC_000069.6 (118562178..119432918)
    See Dpyd in Epigenomics, MapViewer

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene microRNA 137 Neighboring gene predicted gene 9916 Neighboring gene ribosomal protein S20 pseudogene Neighboring gene polypyrimidine tract binding protein 2

    Markers

    Homology

    Clone Names

    • MGC37940

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    NADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    dihydroorotate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    dihydroorotate oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    dihydropyrimidine dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dihydropyrimidine dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    electron carrier activity IEA
    Inferred from Electronic Annotation
    more info
     
    iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    uracil binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    UMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    purine nucleobase catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    pyrimidine nucleobase catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pyrimidine nucleobase catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to nutrient ISO
    Inferred from Sequence Orthology
    more info
     
    thymidine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    thymine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    uracil catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    uracil metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    dihydropyrimidine dehydrogenase [NADP(+)]
    Names
    dihydropyrimidine dehydrogenase [NADP(+)]
    DHPDHase
    dihydrouracil dehydrogenase
    dihydrothymine dehydrogenase
    NP_740748.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_170778.2NP_740748.1  dihydropyrimidine dehydrogenase [NADP(+)]

      Status: PROVISIONAL

      Source sequence(s)
      AC110513, AC115012, AC115017, AC115935, AC116409, AC121544, AC122183, AC152401, AC161223
      Consensus CDS
      CCDS17797.1
      UniProtKB/Swiss-Prot
      Q8CHR6
      Related
      ENSMUSP00000039429, OTTMUSP00000031746, ENSMUST00000039177, OTTMUST00000064012
      Conserved Domains (6) summary
      COG0167
      Location:532848
      Blast Score: 560
      PyrD; Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]
      cd02940
      Location:532834
      Blast Score: 1281
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      PRK11749
      Location:53511
      Blast Score: 879
      PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional
      pfam13237
      Location:948997
      Blast Score: 140
      Fer4_10; 4Fe-4S dicluster domain
      pfam13450
      Location:194238
      Blast Score: 118
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl02805
      Location:945963
      Blast Score: 79
      Fer4; 4Fe-4S binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p1 C57BL/6J

      Range
      118562178..119432918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000025.1 Alternate Mm_Celera

      Range
      124970410..125843833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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