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    USP15 ubiquitin specific peptidase 15 [ Homo sapiens ]

    Gene ID: 9958, updated on 11-May-2012

    Summary

    Official Symbol
    USP15provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 15provided by HGNC
    Primary source
    HGNC:12613
    See related
    Ensembl:ENSG00000135655; HPRD:05293; MIM:604731; Vega:OTTHUMG00000170186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNPH4; UNPH-2; FLJ55073; KIAA0529; MGC74854; MGC131982; MGC149838
    Summary
    This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

    Genomic context

    Location :
    12q14
    Sequence :
    Chromosome: 12; NC_000012.11 (62654187..62799898)
    See USP15 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 Neighboring gene ribosomal protein S3 pseudogene 6 Neighboring gene Kruppel-like factor 17 pseudogene 1 Neighboring gene MON2 homolog (S. cerevisiae) Neighboring gene chromosome 12 open reading frame 61

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_006304.1 NP_002733.1 PRKD1    BIND  PubMed PKD phosphorylates USP15. 
    NP_006304.1     BIND  PubMed CK2 phosphorylates USP15. 
    BioGRID:115283 BioGRID:106667 ADSL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:106728 ALDOA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:107261 CALML3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:107396 CD40    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:107572 CKB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:107859 CSTF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:108040 DFFA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:108465 FABP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:110079 KRT31    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:110082 KRT33B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:110083 KRT34    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:110084 KRT35    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:110085 KRT81    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:110089 KRT85    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:110154 LGALS7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:126287 LRRC15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:121778 LSM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:117336 LSM4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:116328 LSM6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:110705 MYH2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:110707 MYH4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:119679 NAA38    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:111245 PGAM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:116459 PHB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:111337 PLA2G2A    BioGRID  PubMed Biochemical Activity 
    BioGRID:115283 BioGRID:115728 PPIH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:114577 PRPF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:117563 PRPF31    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:114576 PRPF4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:111689 PSMD11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:111685 PSMD7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115283 BioGRID:115149 RNF40    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:115082 SART3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:114472 SELENBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:110261 SMAD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115283 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115283 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:115283 BioGRID:110264 SMAD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115283 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:113041 TRAF6    BioGRID  PubMed Biochemical Activity 
    BioGRID:115283 BioGRID:122325 TUT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity; Reconstituted Complex 
    BioGRID:115283 BioGRID:113175 UBE2G2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115283 BioGRID:118150 UBE2S    BioGRID  PubMed Biochemical Activity 
    BioGRID:115283 BioGRID:113866 USP11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115283 BioGRID:115283 USP15    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex 
    BioGRID:115283 BioGRID:133813 VSIG8    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin thiolesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 15
    Names
    ubiquitin carboxyl-terminal hydrolase 15
    ubiquitin thioesterase 15
    deubiquitinating enzyme 15
    ubiquitin thiolesterase 15
    ubiquitin-specific-processing protease 15
    NP_006304.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252078.1NP_001239007.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC079035, AF153604, DB451322
      UniProtKB/Swiss-Prot
      Q9Y4E8
      Conserved Domains (3) summary
      cd02674
      Location:784931
      Blast Score: 507
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:289477
      Blast Score: 257
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cl12116
      Location:24121
      Blast Score: 282
      DUSP; DUSP domain
    2. NM_001252079.1NP_001239008.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and lacks a large portion of the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI027693, BC063454, DB451322
      UniProtKB/TrEMBL
      Q9H8G9
      Conserved Domains (1) summary
      cl12116
      Location:24121
      Blast Score: 269
      DUSP; DUSP domain
    3. NM_006313.2NP_006304.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC079035, AF106069, BC125123, DB451322
      Consensus CDS
      CCDS8963.1
      UniProtKB/TrEMBL
      Q08AL5
      UniProtKB/Swiss-Prot
      Q9Y4E8
      Related
      ENSP00000258123, OTTHUMP00000243158, ENST00000353364, OTTHUMT00000407833
      Conserved Domains (3) summary
      cd02674
      Location:755902
      Blast Score: 506
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:260448
      Blast Score: 257
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cl12116
      Location:24121
      Blast Score: 282
      DUSP; DUSP domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      62654187..62799898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      59705123..59851058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC048342.17 (2004..35994) None
    genomic AC079035.46 (1310..109076) None
    genomic AC117370.5 None
    genomic CH471054.1 EAW97104.1
      EAW97105.1
      EAW97106.1
    mRNA AB011101.2 BAA25455.2
    mRNA AF013990.1 AAG28973.1
    mRNA AF106069.1 AAD52099.1
    mRNA AF153604.1 AAD41086.1
    mRNA AI027693.1 None
    mRNA AK023703.1 BAB14648.1
    mRNA AK292337.1 BAF85026.1
    mRNA AK295947.1 BAH12226.1
    mRNA AK297759.1 BAG60108.1
    mRNA BC020688.1 AAH20688.1
    mRNA BC063454.1 AAH63454.1
    mRNA BC110908.1 AAI10909.1
    mRNA BC125123.1 AAI25124.1
    mRNA DB451322.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08AL5 GenPept UniProtKB/TrEMBL:Q08AL5
    Q2NL66 GenPept UniProtKB/TrEMBL:Q2NL66
    Q9H8G9 GenPept UniProtKB/TrEMBL:Q9H8G9
    Q9Y4E8.3 GenPept UniProtKB/Swiss-Prot:Q9Y4E8

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