Format

Send to:

Choose Destination

USP15 ubiquitin specific peptidase 15 [ Homo sapiens (human) ]

Gene ID: 9958, updated on 8-May-2016
Official Symbol
USP15provided by HGNC
Official Full Name
ubiquitin specific peptidase 15provided by HGNC
Primary source
HGNC:HGNC:12613
See related
Ensembl:ENSG00000135655 HPRD:05293; MIM:604731; Vega:OTTHUMG00000170186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNPH4; UNPH-2
Summary
This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]
Orthologs
Location:
12q14
Exon count:
25
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (62260340..62409721)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (62654121..62803501)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 19 member A2, C-C motif chemokine like Neighboring gene ribosomal protein S3 pseudogene 6 Neighboring gene Kruppel-like factor 17 pseudogene 1 Neighboring gene microRNA 6125 Neighboring gene uncharacterized LOC102724318 Neighboring gene MON2 homolog, regulator of endosome-to-Golgi trafficking Neighboring gene long intergenic non-protein coding RNA 1465

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of lung function decline in adults with and without asthma.
NHGRI GWA Catalog
  • Downregulation of TGF-beta receptor signaling, organism-specific biosystem (from REACTOME)
    Downregulation of TGF-beta receptor signaling, organism-specific biosystemTGF-beta receptor signaling is downregulated by proteasome and lysosome-mediated degradation of ubiquitinated TGFBR1, SMAD2 and SMAD3, as well as by dephosphorylation of TGFBR1, SMAD2 and SMAD3. In t...
  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
    Signaling by TGF-beta Receptor Complex, organism-specific biosystemThe TGF-beta/BMP pathway incorporates several signaling pathways that share most, but not all, components of a central signal transduction engine. The general signaling scheme is rather simple: upon ...
  • TGF-beta receptor signaling activates SMADs, organism-specific biosystem (from REACTOME)
    TGF-beta receptor signaling activates SMADs, organism-specific biosystemBinding of transforming growth factor beta 1 (TGF beta 1, i.e. TGFB1) to TGF beta receptor type 2 (TGFBR2) activates TGF beta receptor signaling cascade. TGFB1 is posttranslationally processed by fur...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ55073, KIAA0529, MGC74854, MGC131982, MGC149838

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitinated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ubiquitin carboxyl-terminal hydrolase 15
Names
deubiquitinating enzyme 15
ubiquitin thioesterase 15
ubiquitin thiolesterase 15
ubiquitin-specific-processing protease 15
NP_001239007.1
NP_001239008.1
NP_006304.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252078.1NP_001239007.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 1

    See identical proteins and their annotated locations for NP_001239007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC079035, AF153604, DB451322
    Consensus CDS
    CCDS58251.1
    UniProtKB/Swiss-Prot
    Q9Y4E8
    Related
    ENSP00000280377, OTTHUMP00000243156, ENST00000280377, OTTHUMT00000407831
    Conserved Domains (6) summary
    smart00695
    Location:24121
    DUSP; Domain in ubiquitin-specific proteases
    COG5560
    Location:12932
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:784931
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam14533
    Location:459597
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam14836
    Location:135222
    Ubiquitin_3; Ubiquitin-like domain
    cl02553
    Location:290474
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  2. NM_001252079.1NP_001239008.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 3

    See identical proteins and their annotated locations for NP_001239008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and lacks a large portion of the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI027693, BC063454, DB451322
    Consensus CDS
    CCDS58250.1
    UniProtKB/Swiss-Prot
    Q9Y4E8
    Related
    ENSP00000309240, OTTHUMP00000243157, ENST00000312635, OTTHUMT00000407832
    Conserved Domains (2) summary
    smart00695
    Location:24121
    DUSP; Domain in ubiquitin-specific proteases
    pfam14836
    Location:135222
    Ubiquitin_3; Ubiquitin-like domain
  3. NM_006313.2NP_006304.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 2

    See identical proteins and their annotated locations for NP_006304.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC079035, AF106069, BC125123, DB451322
    Consensus CDS
    CCDS8963.1
    UniProtKB/Swiss-Prot
    Q9Y4E8
    Related
    ENSP00000258123, OTTHUMP00000243158, ENST00000353364, OTTHUMT00000407833
    Conserved Domains (6) summary
    smart00695
    Location:24121
    DUSP; Domain in ubiquitin-specific proteases
    COG5560
    Location:12903
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:755902
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam14533
    Location:430568
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam14836
    Location:135222
    Ubiquitin_3; Ubiquitin-like domain
    cl02553
    Location:261445
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    62260340..62409721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719718.2XP_006719781.1  

    Conserved Domains (4) summary
    smart00695
    Location:24121
    DUSP; Domain in ubiquitin-specific proteases
    pfam14533
    Location:459597
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam14836
    Location:135222
    Ubiquitin_3; Ubiquitin-like domain
    cl02553
    Location:290474
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  2. XM_005269259.2XP_005269316.1  

    See identical proteins and their annotated locations for XP_005269316.1

    Conserved Domains (4) summary
    cd02674
    Location:663810
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam14533
    Location:338476
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam14836
    Location:14101
    Ubiquitin_3; Ubiquitin-like domain
    cl02553
    Location:169353
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  3. XM_005269261.2XP_005269318.1  

    See identical proteins and their annotated locations for XP_005269318.1

    Conserved Domains (3) summary
    cd02674
    Location:451598
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam14533
    Location:126264
    USP7_C2; Ubiquitin-specific protease C-terminal
    cl02553
    Location:44147
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RNA

  1. XR_944851.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    62622031..62771333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)