OXSR1 oxidative-stress responsive 1 [Homo sapiens] - Gene

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Summary

Official Symbol: OXSR1provided by HGNC
Official Full Name: oxidative-stress responsive 1provided by HGNC
Primary source: HGNC:8508
See related: Ensembl:ENSG00000172939; HPRD:06809; MIM:604046; Vega:OTTHUMG00000131084
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OSR1; KIAA1101
Summary: The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 3p22.2

Sequence :: Chromosome: 3; NC_000003.11 (38207026..38296979)

See OXSR1 in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

OXSR1 and WNK3 transcripts were substantially overexpressed in subjects with schizophrenia relative to comparison subjects.
Title: Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia.
Observational study of gene-disease association. (HuGE Navigator)
Title: STK39 is an independent risk factor for male hypertension in Han Chinese.
crystal structure of OSR1 kinase domain has been solved at 2.25 A; OSR1 forms a domain-swapped dimer in an inactive conformation, in which P+1 loop and alphaEF helix are swapped between dimer-related monomers
Title: Crystal structure of domain-swapped STE20 OSR1 kinase domain.
The WNK1-SPAK/OSR1 signalling pathway plays a key role in controlling the phosphorylation and activity of NCC.
Title: Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.
The first crystal structure of an OSR1 fragment encompassing the catalytic domain of the enzyme, is reported.
Title: Structure of the OSR1 kinase, a hypertension drug target.
These results provide the first molecular insight into the mechanism by which the SPAK and OSR1 kinases specifically recognize their upstream activators and downstream substrates.
Title: Structural insights into the recognition of substrates and activators by the OSR1 kinase.
OXSR1 kinase is shown to interact with the three RELT family members RELT, RELL1, and RELL2 by in vitro co-immunoprecipitation; additionally, OXSR1 phosphorylates RELT family members in an in vitro kinase assay.
Title: Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1.
isolation and characterization of OSR1 (oxidative stress-responsive 1), one of two human Fray homologs. OSR1 is a 58-kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines
Title: Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.
WNK1 and SPAK/OSR1 mediate the hypotonic stress signaling pathway to cation-chloride-coupled cotransporters
Title: WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.
data establish that the CCT domain functions as a multipurpose docking site, enabling SPAK/OSR1 to interact with substrates (NKCC1) and activators (WNK1/WNK4)
Title: Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.

Submit: New GeneRIF Correction See all (12)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
O95747	O00238	BMPR1B	HPRD	PubMed
O95747	Q13153	PAK1	HPRD	PubMed
O95747	Receptor expressed in lymphoid tissues like 1	RELL1	HPRD	PubMed
O95747	Q13621	SLC12A1	HPRD	PubMed
O95747	P55011	SLC12A2	HPRD	PubMed
O95747	Q9UHW9	SLC12A6	HPRD	PubMed
O95747	Q9HCE7	SMURF1	HPRD	PubMed
O95747	P36897	TGFBR1	HPRD	PubMed
BioGRID:115269	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115269	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
intracellular protein kinase cascade	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
response to oxidative stress	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: serine/threonine-protein kinase OSR1

Names: serine/threonine-protein kinase OSR1; oxidative stress-responsive 1 protein

NP_005100.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005109.2 → NP_005100.1 serine/threonine-protein kinase OSR1

Status: REVIEWED

Source sequence(s)

AB017642, BC008726, BI090706

Consensus CDS

CCDS2675.1

UniProtKB/Swiss-Prot

O95747

Related

ENSP00000311713, OTTHUMP00000161719, ENST00000311806, OTTHUMT00000253744

Conserved Domains (3) summary

cd06610
Location:15 – 291
Blast Score: 1391

STKc_OSR1_SPAK; Catalytic domain of the Protein Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

smart00220
Location:17 – 291
Blast Score: 727

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam12202
Location:434 – 465
Blast Score: 120

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p5 Primary Assembly

Range

38207026..38296979

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

38248039..38338925

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP006193.1 (143980..200495)	None
genomic	AP006308.1 (5082..16321)	None
genomic	AP006309.1 (146013..168210)	None
genomic	CH471055.1	EAW64522.1
		EAW64523.1
		EAW64524.1
		EAW64525.1
genomic	DQ201638.1	ABA27097.1
mRNA	AB017642.1	BAA75674.1
mRNA	AB029024.1	BAA83053.2
mRNA	AF087893.1	AAP97192.1
mRNA	AK309634.1	None
mRNA	BC008726.2	AAH08726.1
mRNA	BI090706.1	None
other-genetic	DQ893255.2	ABM84181.1
other-genetic	DQ896584.2	ABM87583.1