Format

Send to:

Choose Destination

OXSR1 oxidative stress responsive 1 [ Homo sapiens (human) ]

Gene ID: 9943, updated on 12-May-2016
Official Symbol
OXSR1provided by HGNC
Official Full Name
oxidative stress responsive 1provided by HGNC
Primary source
HGNC:HGNC:8508
See related
Ensembl:ENSG00000172939 HPRD:06809; MIM:604046; Vega:OTTHUMG00000131084
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OSR1
Summary
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Orthologs
Location:
3p22.2
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (38165260..38255488)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (38207022..38296979)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene deleted in lung and esophageal cancer 1 Neighboring gene acetyl-CoA acyltransferase 1 Neighboring gene uncharacterized LOC101928234 Neighboring gene myeloid differentiation primary response 88 Neighboring gene cell division cycle 42 pseudogene Neighboring gene solute carrier family 22 member 13 Neighboring gene solute carrier family 22 member 14

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1101

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor signaling protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cellular hypotonic response IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of potassium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of rubidium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
signal transduction by protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein kinase OSR1
Names
OXSR1
oxidative stress-responsive 1 protein
oxidative-stress responsive 1
NP_005100.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005109.2NP_005100.1  serine/threonine-protein kinase OSR1

    See identical proteins and their annotated locations for NP_005100.1

    Status: REVIEWED

    Source sequence(s)
    AB017642, BC008726, BI090706
    Consensus CDS
    CCDS2675.1
    UniProtKB/Swiss-Prot
    O95747
    UniProtKB/TrEMBL
    A0A024R2M7
    Related
    ENSP00000311713, OTTHUMP00000161719, ENST00000311806, OTTHUMT00000253744
    Conserved Domains (2) summary
    smart00220
    Location:17291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:15291
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    38165260..38255488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534331.1XP_011532633.1  

    Conserved Domains (2) summary
    smart00220
    Location:77344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:77344
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
  2. XM_005265638.1XP_005265695.1  

    Conserved Domains (2) summary
    smart00220
    Location:31224
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:31224
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011534332.1XP_011532634.1  

    Conserved Domains (3) summary
    pfam12202
    Location:242273
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl21453
    Location:199
    PKc_like; Protein Kinases, catalytic domain
    cl22856
    Location:186312
    SNARE; SNARE motif

RNA

  1. XR_940531.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    38158703..38248663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)