Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    XYLB xylulokinase homolog (H. influenzae) [ Homo sapiens (human) ]

    Gene ID: 9942, updated on 9-Jun-2013
    Official Symbol
    XYLBprovided by HGNC
    Official Full Name
    xylulokinase homolog (H. influenzae)provided by HGNC
    Primary source
    HGNC:12839
    See related
    Ensembl:ENSG00000093217; HPRD:06812; MIM:604049; Vega:OTTHUMG00000131294
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009]
    Location :
    3p22-p21.3
    Sequence :
    Chromosome: 3; NC_000003.11 (38388251..38456467)
    See XYLB in Epigenomics

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 22, member 14 Neighboring gene deleted in lung and esophageal cancer 1 pseudogene 1 Neighboring gene ACVR2B antisense RNA 1 Neighboring gene activin A receptor, type IIB Neighboring gene endo/exonuclease (5'-3'), endonuclease G-like Neighboring gene D-dopachrome tautomerase pseudogene 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism. Bunker RD, et al. J Biol Chem, 2013 Jan 18. PMID 23179721.
    2. Use of a repetitive seeding protocol to obtain diffraction-quality crystals of a putative human D-xylulokinase. Bunker RD, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Oct 1. PMID 23027762.
    3. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.
    4. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (12) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Xylulose binds to domain-I and ADP to domain-II, but in an open form of D-xylulokinase they are 10 A apart, implying that a large scale conformational change is required for catalysis.
      Title: Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism.
    2. crystals of D-xylulokinase proved to be trigonal, with point-group symmetry 3 and unit-cell parameters a = b = 101.87, c = 158.85 A degrees
      Title: Use of a repetitive seeding protocol to obtain diffraction-quality crystals of a putative human D-xylulokinase.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:115268 BioGRID:112921 THOP1    BioGRID  PubMed Co-fractionation 
    BioGRID:115268 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Homology

    Clone Names

    • FLJ10343, FLJ12539, FLJ22075

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    xylulokinase activity IDA
    Inferred from Direct Assay
    more info
    		  
    Process Evidence Code Pubs
    D-xylose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    generation of precursor metabolites and energy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    xylulose catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    xylulose metabolic process IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    xylulose kinase
    Names
    xylulose kinase
    NP_005099.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005108.3 → NP_005099.2  xylulose kinase

      Status: REVIEWED

      Source sequence(s)
      AK022601, BC039712, BC052984, BC137076, BI090475
      Consensus CDS
      CCDS2678.1
      UniProtKB/Swiss-Prot
      O75191
      Related
      ENSP00000207870, OTTHUMP00000161968, ENST00000207870, OTTHUMT00000254062
      Conserved Domains (2) summary
      PLN02669
      Location:11 – 535
      Blast Score: 1455
      PLN02669; xylulokinase
      cd07776
      Location:9 – 479
      Blast Score: 2075
      FGGY_D-XK_euk; eukaryotic D-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p10 Primary Assembly

      Range
      38388251..38456467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      38430197..38498798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018914.1 Alternate CHM1_1.0

      Range
      38320678..38388889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01024820.1 (38988..86118) None
    genomic ABBA01024821.1 None
    genomic ABBA01024822.1 None
    genomic ABBA01024823.1 None
    genomic ABBA01024824.1 None
    genomic ABBA01024825.1 None
    genomic AMYH01013092.1 (4786..72997) None
    genomic AP006191.1 (2591..18098) None
    genomic AP006193.1 None
    genomic CH471055.1 EAW64531.1
      EAW64532.1
      EAW64533.1
      EAW64534.1
    mRNA AB015046.1 BAA31527.1
    mRNA AK001205.1 BAG50868.1
    mRNA AK022601.1 None
    mRNA AK025728.1 None
    mRNA AK293325.1 BAG56843.1
    mRNA AK314386.1 BAG37011.1
    mRNA BC030231.2 AAH30231.1
    mRNA BC039712.1 None
    mRNA BC052984.1 None
    mRNA BC137076.1 AAI37077.1
    mRNA BC137080.1 AAI37081.1
    mRNA BI090475.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75191.3 GenPept UniProtKB/Swiss-Prot:O75191

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content