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    CDC25B cell division cycle 25 homolog B (S. pombe) [ Homo sapiens ]

    Gene ID: 994, updated on 19-May-2012
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    Summary

    Official Symbol
    CDC25Bprovided by HGNC
    Official Full Name
    cell division cycle 25 homolog B (S. pombe)provided by HGNC
    Primary source
    HGNC:1726
    Locus tag
    RP5-1009E24.3
    See related
    Ensembl:ENSG00000101224; HPRD:00307; MIM:116949; Vega:OTTHUMG00000031764
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    20p13
    Sequence :
    Chromosome: 20; NC_000020.10 (3776401..3786762)
    See CDC25B in Epigenomics, MapViewer

    Chromosome 20 - NC_000020.10Genomic Context describing neighboring genes Neighboring gene sperm flagellar 1 Neighboring gene centromere protein B, 80kDa Neighboring gene adaptor-related protein complex 5, sigma 1 subunit Neighboring gene mitochondrial antiviral signaling protein

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia. Nakamura S, et al. PLoS One, 2011. PMID 22132193.
    2. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    3. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (92) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Transcriptional repression mediated by IER5 regulates Cdc25B expression levels via the release of NF-YB and p300 in acute myeloid leukemia.
      Title: Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia.
    2. We identified CDC25B as novel miR-148a target which may confer a proliferative advantage in pancreatic ductal adenocarcinomas.
      Title: MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B.
    3. Ser169 phosphorylation can disrupt 14-3-3 binding to Ser151 activating Cdc25B3, providing a mechanism for regulating Cdc25B3 activation without dephosphorylation of the 14-3-3 binding sites.
      Title: Phosphorylation of Cdc25B3 Ser169 regulates 14-3-3 binding to Ser151 and Cdc25B activity.
    4. there are 13 sites phosphorylated by PLK1 in CDC25B.This study illustrates the complexity of the phosphorylation pattern and of the subsequent regulation of CDC25B activity.
      Title: Study of the docking-dependent PLK1 phosphorylation of the CDC25B phosphatase.
    5. Deletion and mutation analyses of the Cdc25B promoter revealed that downregulation by p53 is dependent on the presence of functional Sp1/Sp3 and NF-Y binding sites
      Title: Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors.
    6. CDC25B forms a close association with Ctn-2 proteins at the centrosome.
      Title: CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity.
    7. Our findings reveal the existence of a previously unrecognized CDC25B isoform that operates specifically in the nucleus to reinitiate G2/M transition after DNA damage
      Title: Identification of N-terminally truncated stable nuclear isoforms of CDC25B that are specifically involved in G2/M checkpoint recovery.
    8. Cdc14A phosphatase prevents premature activation of Cdk1 regulating Cdc25A and Cdc25B at the entry into mitosis.
      Title: Human Cdc14A phosphatase modulates the G2/M transition through Cdc25A and Cdc25B.
    9. The mitotic phosphorylation of Ser(321) acts to maintain full activation of Cdc25B by disrupting 14-3-3 binding to Ser(323) and enhancing the dephosphorylation of Ser(323) to block 14-3-3 binding to this site.
      Title: Mitotic phosphorylation of Cdc25B Ser321 disrupts 14-3-3 binding to the high affinity Ser323 site.
    10. CDC25B a minor role in the pathogenesis and/or progression of vulvar squamous cell carcinomas.
      Title: Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes.
    Submit: New GeneRIF Correction See all (44)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P30305 P10275 AR    HPRD  PubMed  
    P30305 O14965 AURKA    HPRD  PubMed  
    P30305 Q8TDC3 BRSK1    HPRD  PubMed  
    P30305 Q8IWQ3 BRSK2    HPRD  PubMed  
    P30305 P06493 CDK1    HPRD  PubMed  
    P30305 O14757 CHEK1    HPRD  PubMed  
    P30305 Q92793 CREBBP    HPRD  PubMed  
    P30305 P68400 CSNK2A1    HPRD  PubMed  
    P30305 P67870 CSNK2B    HPRD  PubMed  
    P30305 P03372 ESR1    HPRD  PubMed  
    P30305 Q13643 FHL3    HPRD  PubMed  
    P30305 Q92831 KAT2B    HPRD  PubMed  
    P30305 NP_001306.1 MAPK14    BIND  PubMed p38-alpha interacts with and phosphorylates CDC25B. 
    P30305 Q16539 MAPK14    HPRD  PubMed  
    P30305 MAPKAPK2    BIND  PubMed An unspecified isoform of MAPKAP kinase-2 interacts with and phosphorylates CDC25B. 
    P30305 Q14680 MELK    HPRD  PubMed  
    P30305 P31947 SFN    HPRD  PubMed  
    P30305 P31946 YWHAB    HPRD  PubMed  
    P30305 P62258 YWHAE    HPRD  PubMed  
    P30305 Q04917 YWHAH    HPRD  PubMed  
    P30305 P27348 YWHAQ    HPRD  PubMed  
    P30305 NP_003397.1 YWHAZ    BIND  PubMed 14-3-3-zeta interacts with phosphorylated CDC25B. 
    P30305 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:107429 BioGRID:106862 AR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107429 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107429 BioGRID:107452 CDK2    BioGRID  PubMed Two-hybrid 
    BioGRID:107429 BioGRID:107536 CHEK1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107429 BioGRID:107841 CSNK2A1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107429 BioGRID:198622 Cdc25b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107429 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107429 BioGRID:116887 FBXW11    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity 
    BioGRID:107429 BioGRID:108594 FOXM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107429 BioGRID:114375 KAT2B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107429 BioGRID:110079 KRT31    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107429 BioGRID:110084 KRT35    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107429 BioGRID:110089 KRT85    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107429 BioGRID:107819 MAPK14    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107429 BioGRID:115171 MELK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107429 BioGRID:111260 PGR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107429 BioGRID:116459 PHB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107429 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    NP_003395.1 YWHAB    BIND  PubMed 14-3-3-beta interacts with cdc25B. 
    BioGRID:107429 BioGRID:113361 YWHAB    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    NP_006752.1 YWHAE    BIND  PubMed 14-3-3-epsilon interacts with cdc25B. 
    BioGRID:107429 BioGRID:113363 YWHAE    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107429 BioGRID:113365 YWHAH    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107429 BioGRID:116168 YWHAQ    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107429 BioGRID:113366 YWHAZ    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora A signaling, organism-specific biosystem
      Aurora A signaling
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cyclin A/B1 associated events during G2/M transition, organism-specific biosystem (from REACTOME)
      Cyclin A/B1 associated events during G2/M transition, organism-specific biosystemCell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions by cyclin-dependent protein kinases. The G2/M transition is regulated through the pho...
    • Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
      Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemCyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. Af...
    • Cyclin B2 mediated events, organism-specific biosystem (from REACTOME)
      Cyclin B2 mediated events, organism-specific biosystemThe two B-type cyclins localize to different regions within the cell and and are thought to have specific roles as CDK1-activating subunits (see Bellanger et al., 2007). Cyclin B1 is primarily cytop...
    • FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      FOXM1 transcription factor network, organism-specific biosystem
      FOXM1 transcription factor network
    • G2/M Transition, organism-specific biosystem (from REACTOME)
      G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
      Mitotic G2-G2/M phases, organism-specific biosystem
      Mitotic G2-G2/M phases
    • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK1 signaling events, organism-specific biosystem
      PLK1 signaling events
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continu...
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • p38 signaling mediated by MAPKAP kinases, organism-specific biosystem (from Pathway Interaction Database)
      p38 signaling mediated by MAPKAP kinases, organism-specific biosystem
      p38 signaling mediated by MAPKAP kinases

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    female meiosis I IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    oocyte maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    peptidyl-tyrosine dephosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of cell cycle cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    intracellular NAS
    Non-traceable Author Statement
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    M-phase inducer phosphatase 2
    Names
    M-phase inducer phosphatase 2
    cell division cycle 25B
    dual specificity phosphatase Cdc25B
    NP_004349.1
    NP_068658.1
    NP_068659.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029040.1 RefSeqGene

      Range
      5001..15362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004358.3 → NP_004349.1  M-phase inducer phosphatase 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as CDC25B1, uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AK092713, BC051711, BX640836, S78187
      Consensus CDS
      CCDS13065.1
      UniProtKB/TrEMBL
      B3KS38
      UniProtKB/Swiss-Prot
      P30305
      UniProtKB/TrEMBL
      Q6MZW8
      Related
      ENSP00000405972, OTTHUMP00000030137, ENST00000439880, OTTHUMT00000077777
      Conserved Domains (2) summary
      cd01530
      Location:398 – 517
      Blast Score: 482
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:99 – 370
      Blast Score: 726
      M-inducer_phosp; M-phase inducer phosphatase

    2. NM_021872.2 → NP_068658.1  M-phase inducer phosphatase 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as CDC25B2, lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 3) compared to isoform 1.
      Source sequence(s)
      AK092713, BC051711, BX640836, S78187, Z68092
      Consensus CDS
      CCDS13066.1
      UniProtKB/TrEMBL
      B3KS38
      UniProtKB/Swiss-Prot
      P30305
      UniProtKB/TrEMBL
      Q6MZW8
      Related
      ENSP00000339170, OTTHUMP00000030138, ENST00000340833, OTTHUMT00000077778
      Conserved Domains (2) summary
      cd01530
      Location:371 – 490
      Blast Score: 484
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:113 – 343
      Blast Score: 622
      M-inducer_phosp; M-phase inducer phosphatase

    3. NM_021873.2 → NP_068659.1  M-phase inducer phosphatase 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as CDC25B3, represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK092713, BC051711, BX640836, S78187
      Consensus CDS
      CCDS13067.1
      UniProtKB/TrEMBL
      B3KS38
      UniProtKB/Swiss-Prot
      P30305
      UniProtKB/TrEMBL
      Q6MZW8
      Related
      ENSP00000245960, OTTHUMP00000030139, ENST00000245960, OTTHUMT00000077779
      Conserved Domains (2) summary
      cd01530
      Location:412 – 531
      Blast Score: 485
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:113 – 384
      Blast Score: 725
      M-inducer_phosp; M-phase inducer phosphatase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000020.10 Reference GRCh37.p5 Primary Assembly

      Range
      3776401..3786762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000152.1 Alternate HuRef

      Range
      3724986..3735364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_021874.2: Suppressed sequence

      Description
      NM_021874.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_212530.1: Suppressed sequence

      Description
      NM_212530.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF036233.1 AAB94622.1
      AAB94623.1
      AAB94624.1
      AAB94625.1
    genomic AL109804.41 CAC17548.1
      CAC17549.1
      CAI18847.1
    genomic AY494082.1 AAR26469.1
    genomic CH471133.3 EAX10491.1
      EAX10493.1
      EAX10494.1
      EAX10496.1
      EAX10498.1
      EAX10499.1
    genomic X96436.1 CAA65303.1
    mRNA AK092713.1 BAG52600.1
    mRNA AK124284.1 None
    mRNA AK295573.1 BAG58472.1
    mRNA AK299028.1 BAG61105.1
    mRNA AK299192.1 BAG61235.1
    mRNA BC006395.2 AAH06395.1
    mRNA BC009953.2 AAH09953.1
    mRNA BC051711.1 AAH51711.1
    mRNA BX640836.1 CAE45909.2
    mRNA BX647988.1 None
    mRNA FR695900.1 CBX26628.1
    mRNA FR695901.1 CBX26629.1
    mRNA M81934.1 AAA58416.1
    mRNA S78187.1 AAB21139.1
    mRNA Z68092.1 CAA92108.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43550 GenPept UniProtKB/TrEMBL:O43550
    P30305.2 GenPept UniProtKB/Swiss-Prot:P30305
    Q6MZW8 GenPept UniProtKB/TrEMBL:Q6MZW8
    Q7LDQ7 GenPept UniProtKB/TrEMBL:Q7LDQ7
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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