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ARHGAP25 Rho GTPase activating protein 25 [ Homo sapiens (human) ]

Gene ID: 9938, updated on 12-May-2016
Official Symbol
ARHGAP25provided by HGNC
Official Full Name
Rho GTPase activating protein 25provided by HGNC
Primary source
HGNC:HGNC:28951
See related
Ensembl:ENSG00000163219 HPRD:09805; MIM:610587; Vega:OTTHUMG00000152621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAIA0053; HEL-S-308
Summary
ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
2p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (68710505..68826833)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68961913..69053965)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domain family 1 pseudogene Neighboring gene prokineticin receptor 1 Neighboring gene uncharacterized LOC105374790 Neighboring gene uncharacterized LOC105374791 Neighboring gene bone morphogenetic protein 10

NHGRI GWAS Catalog

Description
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
NHGRI GWA Catalog
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
rho GTPase-activating protein 25
Names
epididymis secretory protein Li 308
rho-type GTPase-activating protein 25

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007231.2NP_001007232.2  rho GTPase-activating protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC097495, AK290396, BC032222, CD695161
    Consensus CDS
    CCDS33214.2
    UniProtKB/Swiss-Prot
    P42331
    Related
    ENSP00000386911, OTTHUMP00000202079, ENST00000409202, OTTHUMT00000327031
    Conserved Domains (3) summary
    cd04390
    Location:156354
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam08618
    Location:401562
    Opi1; Transcription factor Opi1
    cd13263
    Location:45157
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
  2. NM_001166276.1NP_001159748.1  rho GTPase-activating protein 25 isoform c

    See identical proteins and their annotated locations for NP_001159748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    BC032222
    Consensus CDS
    CCDS54364.1
    UniProtKB/Swiss-Prot
    P42331
    Related
    ENSP00000386241, OTTHUMP00000202081, ENST00000409220, OTTHUMT00000327040
    Conserved Domains (3) summary
    cd04390
    Location:149347
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam08618
    Location:394555
    Opi1; Transcription factor Opi1
    cd13263
    Location:38150
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
  3. NM_001166277.1NP_001159749.1  rho GTPase-activating protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
    Source sequence(s)
    AC097495, AK297056, BC032222, CD695161
    Consensus CDS
    CCDS54363.1
    UniProtKB/Swiss-Prot
    P42331
    Related
    ENSP00000420583, OTTHUMP00000214416, ENST00000467265, OTTHUMT00000353949
    Conserved Domains (3) summary
    cd04390
    Location:117314
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam08618
    Location:361522
    Opi1; Transcription factor Opi1
    cl17171
    Location:45120
    PH-like; Pleckstrin homology-like domain
  4. NM_014882.2NP_055697.1  rho GTPase-activating protein 25 isoform b

    See identical proteins and their annotated locations for NP_055697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    BC032222, D29642
    Consensus CDS
    CCDS46312.1
    UniProtKB/Swiss-Prot
    P42331
    UniProtKB/TrEMBL
    V9HWC8
    Related
    ENSP00000386863, OTTHUMP00000202080, ENST00000409030, OTTHUMT00000327032
    Conserved Domains (3) summary
    cd04390
    Location:148346
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam08618
    Location:393554
    Opi1; Transcription factor Opi1
    cd13263
    Location:38148
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    68710505..68826833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533207.1XP_011531509.1  

    See identical proteins and their annotated locations for XP_011531509.1

    Conserved Domains (3) summary
    cd04390
    Location:130328
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam08618
    Location:375536
    Opi1; Transcription factor Opi1
    cd13263
    Location:19131
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
  2. XM_005264675.1XP_005264732.1  

    See identical proteins and their annotated locations for XP_005264732.1

    UniProtKB/Swiss-Prot
    P42331
    Conserved Domains (3) summary
    cd04390
    Location:155353
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam08618
    Location:400561
    Opi1; Transcription factor Opi1
    cd13263
    Location:45155
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
  3. XM_005264676.1XP_005264733.1  

    Conserved Domains (3) summary
    cd04390
    Location:117315
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam08618
    Location:362523
    Opi1; Transcription factor Opi1
    cl17171
    Location:45122
    PH-like; Pleckstrin homology-like domain
  4. XM_011533208.1XP_011531510.1  

    See identical proteins and their annotated locations for XP_011531510.1

    Conserved Domains (3) summary
    cd04390
    Location:130328
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam08618
    Location:375536
    Opi1; Transcription factor Opi1
    cd13263
    Location:19131
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
  5. XM_011533206.1XP_011531508.1  

    See identical proteins and their annotated locations for XP_011531508.1

    Conserved Domains (3) summary
    cd04390
    Location:130328
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam08618
    Location:375536
    Opi1; Transcription factor Opi1
    cd13263
    Location:19131
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
  6. XM_011533209.1XP_011531511.1  

    Related
    ENSP00000417818, OTTHUMP00000214421, ENST00000497259, OTTHUMT00000353955
    Conserved Domains (2) summary
    cd04390
    Location:38236
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam08618
    Location:283444
    Opi1; Transcription factor Opi1
  7. XM_011533210.1XP_011531512.1  

    Related
    ENSP00000417467, OTTHUMP00000214422, ENST00000479844, OTTHUMT00000353956
    Conserved Domains (2) summary
    pfam08618
    Location:127288
    Opi1; Transcription factor Opi1
    cl02570
    Location:180
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    68891239..68983315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)