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    CDC25A cell division cycle 25 homolog A (S. pombe) [ Homo sapiens ]

    Gene ID: 993, updated on 11-May-2012
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    Summary

    Official Symbol
    CDC25Aprovided by HGNC
    Official Full Name
    cell division cycle 25 homolog A (S. pombe)provided by HGNC
    Primary source
    HGNC:1725
    See related
    Ensembl:ENSG00000164045; HPRD:00305; MIM:116947; Vega:OTTHUMG00000133535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC25A2
    Summary
    CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    3p21
    Sequence :
    Chromosome: 3; NC_000003.11 (48198668..48229801, complement)
    See CDC25A in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 4 Neighboring gene vacuolar protein sorting 26 homolog B (S. pombe) pseudogene Neighboring gene ribosomal protein L17 pseudogene 16 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1 pseudogene 1 Neighboring gene microRNA 4443 Neighboring gene cathelicidin antimicrobial peptide

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The cell cycle regulator CDC25A is a target for JAK2V617F oncogene. Gautier EF, et al. Blood, 2012 Feb 2. PMID 22065597.
    2. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    5. Cdc25A regulates matrix metalloprotease 1 through Foxo1 and mediates metastasis of breast cancer cells. Feng X, et al. Mol Cell Biol, 2011 Aug. PMID 21670150.

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. CDC25A deregulation may be involved in hematopoietic cells expansion in JAK2(V617F) patients, making this protein an attracting potential therapeutic target.
      Title: The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.
    2. Cdc25A enhances Foxo1 stability by dephosphorylating Cdk2, and Foxo1 was shown to directly regulate transcription of the metastatic factor MMP1.
      Title: Cdc25A regulates matrix metalloprotease 1 through Foxo1 and mediates metastasis of breast cancer cells.
    3. CDC25A, VAV1, TP73, BRCA1 and ZAP70 may be novel markers for predicting the effectiveness of radiotherapy in CRC patients.
      Title: CDC25A, VAV1, TP73, BRCA1 and ZAP70 gene overexpression correlates with radiation response in colorectal cancer.
    4. High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/beta-catenin target gene, CDC25A.
      Title: High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A.
    5. Cdc14A phosphatase prevents premature activation of Cdk1 regulating Cdc25A and Cdc25B at the entry into mitosis.
      Title: Human Cdc14A phosphatase modulates the G2/M transition through Cdc25A and Cdc25B.
    6. This study demonistratef that the expression levels of CDC25s in human gliomas, and found that CDC25A is overexpressed, and significantly correlate with Ki-67 expression.
      Title: CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples.
    7. Results reveal an unexpected role of Cdc25A down-regulation and the inhibitory phosphorylation of cdk2 T14 and Y15 in cell cycle quiescence during muscle differentiation and implicate miRNAs-322 and -503 in the process.
      Title: MiR-322/424 and -503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A.
    8. 263C/T and -51C/G polymorphisms of CDC25A gene could be candidate markers for earlier diagnosis and targets for breast cancer therapy.
      Title: CDC 25A gene 263C/T, -350C/T, and -51C/G polymorphisms in breast carcinoma.
    9. results suggest TRB3 is a regulator for adjusting the expression level of Cdc25A both in a normal and a genotoxic conditions
      Title: Dual mode of regulation of cell division cycle 25 A protein by TRB3.
    10. 14-3-3 protein gamma mediates the interaction between Checkpoint kinase 1 and Cdc25A.
      Title: 14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage.
    Submit: New GeneRIF Correction See all (67)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000003.9 NP_005216.1 E2F1    BIND  PubMed E2F1 interacts with the Cdc25A promoter region. 
    NC_000003.9 NP_004082.1 E2F2    BIND  PubMed E2F2 interacts with the Cdc25A promoter region. 
    NC_000003.9 NP_001940.1 E2F3    BIND  PubMed E2F3 interacts with the Cdc25A promoter. 
    NC_000003.9 NP_001941.2 E2F4    BIND  PubMed E2F4 interacts with the Cdc25A promoter region. 
    NP_001780.2 NP_001265.1 CHEK1    BIND  PubMed Chk1 phosphorylates Cdc25A-a. This interaction was modeled on a demonstrated interaction between human Chk1 and Cdc25A from an unspecified species. 
    NP_963861.1 NP_001265.1 CHEK1    BIND  PubMed Chk1 phosphorylates Cdc25A-b. This interaction was modeled on a demonstrated interaction between human Chk1 and Cdc25A from an unspecified species. 
    P30304 P10275 AR    HPRD  PubMed  
    P30304 Q9Y297 BTRC    HPRD  PubMed  
    P30304 P78396 CCNA1    HPRD  PubMed  
    P30304 P14635 CCNB1    HPRD  PubMed  
    P30304 P24864 CCNE1    HPRD  PubMed  
    P30304 P06493 CDK1    HPRD  PubMed  
    P30304 P24941 CDK2    HPRD  PubMed  
    P30304 Q16667 CDKN3    HPRD  PubMed  
    P30304 O14757 CHEK1    HPRD  PubMed  
    P30304 O96017 CHEK2    HPRD  PubMed  
    P30304 P39880 CUX1    HPRD  PubMed  
    P30304 P00533 EGFR    HPRD  PubMed  
    P30304 Q9UKB1 FBXW11    HPRD  PubMed  
    P30304 P01112 HRAS    HPRD  PubMed  
    P30304 Q99683 MAP3K5    HPRD  PubMed  
    P30304 P41227 NAA10    HPRD  PubMed  
    P30304 P11309 PIM1    HPRD  PubMed  
    P30304 P04049 RAF1    HPRD  PubMed  
    P30304 Q13464 ROCK1    HPRD  PubMed  
    P30304 P84022 SMAD3    HPRD  PubMed  
    P30304 Ubiquitin B UBB    HPRD  PubMed  
    P30304 P31946 YWHAB    HPRD  PubMed  
    P30304 P62258 YWHAE    HPRD  PubMed  
    P30304 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:107428 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107428 BioGRID:114417 CCNA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107428 BioGRID:107332 CCNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107428 BioGRID:107338 CCNE1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107428 BioGRID:107452 CDK2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107428 BioGRID:107536 CHEK1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107428 BioGRID:116369 CHEK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107428 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107428 BioGRID:108183 DUSP8    BioGRID  PubMed Two-hybrid 
    BioGRID:107428 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107428 BioGRID:120027 FAM193B    BioGRID  PubMed Two-hybrid 
    BioGRID:107428 BioGRID:116887 FBXW11    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107428 BioGRID:110381 MAP3K5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107428 BioGRID:107819 MAPK14    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107428 BioGRID:113881 NAA10    BioGRID  PubMed Two-hybrid 
    BioGRID:107428 BioGRID:111310 PIM1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107428 BioGRID:111831 RAF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107428 BioGRID:112020 ROCK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107428 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107428 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    NP_003395.1 YWHAB    BIND  PubMed 14-3-3-beta interacts with cdc25A. 
    BioGRID:107428 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    NP_006752.1 YWHAE    BIND  PubMed 14-3-3-epsilon interacts with cdc25A. 
    BioGRID:107428 BioGRID:113363 YWHAE    BioGRID  PubMed Two-hybrid 
    BioGRID:107428 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107428 BioGRID:113366 YWHAZ    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of ATR in response to replication stress, organism-specific biosystem (from REACTOME)
      Activation of ATR in response to replication stress, organism-specific biosystemGenotoxic stress caused by DNA damage or stalled replication forks can lead to genomic instability. To guard against such instability, genotoxically-stressed cells activate checkpoint factors that ha...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cyclin A/B1 associated events during G2/M transition, organism-specific biosystem (from REACTOME)
      Cyclin A/B1 associated events during G2/M transition, organism-specific biosystemCell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions by cyclin-dependent protein kinases. The G2/M transition is regulated through the pho...
    • Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
      Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemCyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. Af...
    • Cyclin B2 mediated events, organism-specific biosystem (from REACTOME)
      Cyclin B2 mediated events, organism-specific biosystemThe two B-type cyclins localize to different regions within the cell and and are thought to have specific roles as CDK1-activating subunits (see Bellanger et al., 2007). Cyclin B1 is primarily cytop...
    • Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
      Cyclin E associated events during G1/S transition, organism-specific biosystemThe transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. This phosphoryl...
    • E2F mediated regulation of DNA replication, organism-specific biosystem (from REACTOME)
      E2F mediated regulation of DNA replication, organism-specific biosystemProgression through G1 and G1 to S-phase transition that initiates DNA synthesis involve many complexes that are regulated by RB1:E2F pathway. RB1:E2F pathway plays a key role in gene expression regu...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • E2F-enabled inhibition of pre-replication complex formation, organism-specific biosystem (from REACTOME)
      E2F-enabled inhibition of pre-replication complex formation, organism-specific biosystemUnder specific conditions, Cyclin B, a mitotic cyclin, can inhibit the functions of pre-replicative complex. E2F1 activates Cdc25A protein which regulates Cyclin B in a positive manner. Cyclin B/Cdk...
    • G0 and Early G1, organism-specific biosystem (from REACTOME)
      G0 and Early G1, organism-specific biosystemIn G0 and early G1 in quiescent cells, p130 (RBL2) bound to E2F4 or E2F5 and either DP1 or DP2, associates with the MuvB complex, forming an evolutionarily conserved DREAM complex, that represses tra...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S DNA Damage Checkpoints, organism-specific biosystem (from REACTOME)
      G1/S DNA Damage Checkpoints, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding ...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • G1/S-Specific Transcription, organism-specific biosystem (from REACTOME)
      G1/S-Specific Transcription, organism-specific biosystemThe E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle. E2F activity is regulated by members of the retinoblastoma protein (pRb) family, resultin...
    • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
      G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
    • G2/M Transition, organism-specific biosystem (from REACTOME)
      G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
      Mitotic G2-G2/M phases, organism-specific biosystem
      Mitotic G2-G2/M phases
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continu...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, organism-specific biosystem (from REACTOME)
      Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, organism-specific biosystemcdc25A protein is degraded by the ubiquitin-proteasome machinery in both terminally differentiating and cycling cells (Bernardi et al. 2000).
    • Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional activation, organism-specific biosystem
      Validated targets of C-MYC transcriptional activation
    • miRNAs involved in DDR, organism-specific biosystem (from WikiPathways)
      miRNAs involved in DDR, organism-specific biosystemMicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo...
    • p53-Independent DNA Damage Response, organism-specific biosystem (from REACTOME)
      p53-Independent DNA Damage Response, organism-specific biosystemIn response to DNA damage due to exposure to ultraviolet light or to ionizing radiation, Cdc25A is phosphorylated by Chk1 or Chk2. The phosphorylation of Cdc25A at ser-123, in response to DNA damage...
    • p53-Independent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
      p53-Independent G1/S DNA damage checkpoint, organism-specific biosystemThe G1 arrest induced by DNA damage has been ascribed to the transcription factor and tumor suppressor protein p53. To be effective within minutes after DNA damage, induction of the G1 block should ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA replication TAS
    Traceable Author Statement
    more info
    		  
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular response to UV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    regulation of cyclin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to radiation IDA
    Inferred from Direct Assay
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    M-phase inducer phosphatase 1
    Names
    M-phase inducer phosphatase 1
    CDC25A2-CAG isoform
    cell division cycle 25A
    dual specificity phosphatase CDC25A
    NP_001780.2
    NP_963861.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001789.2 → NP_001780.2  M-phase inducer phosphatase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AI917350, BC007401, BQ065803, BX392016
      Consensus CDS
      CCDS2760.1
      UniProtKB/Swiss-Prot
      P30304
      Related
      ENSP00000303706, OTTHUMP00000164816, ENST00000302506, OTTHUMT00000257512
      Conserved Domains (2) summary
      cd01530
      Location:357 – 475
      Blast Score: 495
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:86 – 329
      Blast Score: 625
      M-inducer_phosp; M-phase inducer phosphatase

    2. NM_201567.1 → NP_963861.1  M-phase inducer phosphatase 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AI917350, AY137580, BC007401, BQ065803, BX392016
      Consensus CDS
      CCDS2761.1
      UniProtKB/Swiss-Prot
      P30304
      Related
      ENSP00000343166, OTTHUMP00000164817, ENST00000351231, OTTHUMT00000257513
      Conserved Domains (2) summary
      cd01530
      Location:317 – 435
      Blast Score: 494
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:86 – 289
      Blast Score: 532
      M-inducer_phosp; M-phase inducer phosphatase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      48198668..48229801, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      48253008..48284141, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC104190.3 (71849..77358) None
    genomic AC124916.3 (181972..207595) None
    genomic AF112978.1 None
    genomic AF527417.1 AAM77917.1
    genomic AJ242714.1 None
    genomic CH471055.1 EAW64849.1
      EAW64850.1
      EAW64851.1
      EAW64852.1
    mRNA AF277722.1 AAG41884.1
    mRNA AI917350.1 None
    mRNA AK290554.1 BAF83243.1
    mRNA AY137580.1 AAN11305.1
    mRNA BC007401.2 AAH07401.1
    mRNA BC018642.2 AAH18642.1
    mRNA BQ065803.1 None
    mRNA BX392016.1 None
    mRNA EU812118.1 ACI43572.1
    mRNA M81933.1 AAA58415.1
    other-genetic DQ890753.2 ABM81679.1
    other-genetic DQ892919.2 ABM83845.1
    other-genetic DQ896168.2 ABM87167.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30304.2 GenPept UniProtKB/Swiss-Prot:P30304
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
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