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RNF10 ring finger protein 10 [ Homo sapiens (human) ]

Gene ID: 9921, updated on 26-May-2016
Official Symbol
RNF10provided by HGNC
Official Full Name
ring finger protein 10provided by HGNC
Primary source
HGNC:HGNC:10055
See related
Ensembl:ENSG00000022840 HPRD:11496; MIM:615998; Vega:OTTHUMG00000168999
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIE2
Summary
The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]
Orthologs
Location:
12q24.31
Exon count:
19
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (120534308..120577594)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120972132..121015397)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene dynein light chain LC8-type 1 Neighboring gene negative regulator of antiviral response (non-protein coding) Neighboring gene coenzyme Q5, methyltransferase Neighboring gene ribosomal protein L29 pseudogene 24 Neighboring gene POP5 homolog, ribonuclease P/MRP subunit Neighboring gene ribosomal protein L11 pseudogene 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
New susceptibility loci associated with kidney disease in type 1 diabetes.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of ring finger protein 10 (RNF10) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0262, MGC126758, MGC126764

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of Schwann cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014868.4NP_055683.3  RING finger protein 10

    See identical proteins and their annotated locations for NP_055683.3

    Status: REVIEWED

    Source sequence(s)
    BC016622, BQ015862, DA103961, DB526099
    Consensus CDS
    CCDS9201.1
    UniProtKB/Swiss-Prot
    Q8N5U6
    UniProtKB/TrEMBL
    A0A024RBP0
    Related
    ENSP00000322242, OTTHUMP00000239906, ENST00000325954, OTTHUMT00000401898
    Conserved Domains (1) summary
    cd00162
    Location:225270
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    120534308..120577594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719717.1XP_006719780.1  

    UniProtKB/Swiss-Prot
    Q8N5U6
    Related
    ENSP00000415682, OTTHUMP00000239907, ENST00000413266, OTTHUMT00000401899
    Conserved Domains (1) summary
    cd00162
    Location:225270
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. XM_005254014.2XP_005254071.1  

    Conserved Domains (1) summary
    cd00162
    Location:225270
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. XM_005254013.1XP_005254070.1  

    Conserved Domains (1) summary
    cd00162
    Location:175220
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  4. XM_011539039.1XP_011537341.1  

    Conserved Domains (1) summary
    cd00162
    Location:4792
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RNA

  1. XR_944850.1 RNA Sequence

  2. XR_944849.1 RNA Sequence

  3. XR_429123.1 RNA Sequence

  4. XR_243026.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    120940932..120984162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)