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    CDC20 cell division cycle 20 homolog (S. cerevisiae) [ Homo sapiens ]

    Gene ID: 991, updated on 20-May-2012
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    Summary

    Official Symbol
    CDC20provided by HGNC
    Official Full Name
    cell division cycle 20 homolog (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:1723
    See related
    Ensembl:ENSG00000117399; HPRD:04686; MIM:603618; Vega:OTTHUMG00000007420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC20A; p55CDC; bA276H19.3; MGC102824
    Summary
    CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1p34.1
    Sequence :
    Chromosome: 1; NC_000001.10 (43824626..43828874)
    See CDC20 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Neighboring gene myeloproliferative leukemia virus oncogene Neighboring gene ELOVL fatty acid elongase 1 Neighboring gene mediator complex subunit 8

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. Lara-Gonzalez P, et al. J Cell Sci, 2011 Dec 15. PMID 22193957.
    2. Cdc20 mediates D-box-dependent degradation of Sp100. Wang R, et al. Biochem Biophys Res Commun, 2011 Dec 2. PMID 22086178.
    3. Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet). Jia L, et al. Mol Biol Cell, 2011 Nov. PMID 21937719.
    4. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. both p31(comet) and ubiquitination of Cdc20 are critical mechanisms of checkpoint inactivation. They act redundantly to promote Mad2 dissociation from Cdc20.
      Title: Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet).
    2. These findings expand our knowledge of both Sp100 and Cdc20 as well as their role in ubiquitination.
      Title: Cdc20 mediates D-box-dependent degradation of Sp100.
    3. Anaphase promoting complex subunit 15(APC15) mediates the constant turnover of CDC20 and mitotic checkpoint protein complexes, allowing the spindle checkpoint assembly to respond to the attachment state of kinetochores.
      Title: APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.
    4. Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10.
      Title: Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10.
    5. These data suggest that APC/C(Cdc20) specifically targets E2F1 for degradation in early mitosis and reveal a novel mechanism for limiting free E2F1 levels in cells, failure of which may compromise cell survival and/or homeostasis.
      Title: APC/C(Cdc20) targets E2F1 for degradation in prometaphase.
    6. the sequential actions of the APC-c(Cdc20) and APC-c(Cdh1) ubiquitin ligases regulate the clearance of Mps1 levels and are critical for Mps1 functions during the cell cycle in human cells.
      Title: Degradation of the human mitotic checkpoint kinase Mps1 is cell cycle-regulated by APC-cCdc20 and APC-cCdh1 ubiquitin ligases.
    7. elevated levels of Ubch10 and Cdc20 degrade cyclin B in hpv-16 iinfected cells, required for exit from mitosis, permitting initiation of the next round of DNA synthesis and cell cycle progression.
      Title: Compromised spindle assembly checkpoint due to altered expression of Ubch10 and Cdc20 in human papillomavirus type 16 E6- and E7-expressing keratinocytes.
    8. Data show that the N terminus of cyclin A binds directly to Cdc20 and with sufficient affinity that it can outcompete the spindle assembly checkpoint proteins.
      Title: How cyclin A destruction escapes the spindle assembly checkpoint.
    9. Data suggest that phosphorylation of Mcl-1 by CDK1-cyclin B1 and its APC/C(Cdc20)-mediated destruction initiates apoptosis if a cell fails to resolve mitosis.
      Title: Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.
    10. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.
      Title: Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.
    Submit: New GeneRIF Correction See all (36)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat The DNA repair gene DNA-PKcs and cell cycle-related genes Cdc20, Cdc25C, KIF2C and CTS1 are downregulated in HIV-1 Tat-expressing human rhabdomyosarcoma cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001246.1 NP_004327.1 BUB1    BIND  PubMed Bub1 interacts with Cdc20. 
    NP_001246.1 NP_001202.3 BUB1B    BIND  PubMed BubR1 interacts with Cdc20. 
    NP_001246.1 NP_114172.1 CCNB1    BIND  PubMed Cyclin B interacts with Cdc20. 
    NP_001246.1 NP_002349.1 MAD2L1    BIND  PubMed MAD2L1 (Mad2) interacts with Cdc20. 
    NP_001246.1 NP_002349.1 MAD2L1    BIND  PubMed Mad2 interacts with Cdc20. 
    NP_001246.1 NP_002349.1 MAD2L1    BIND  PubMed MAD2 interacts with p55CDC. 
    NP_001246.1 NP_004210.1 PTTG1    BIND  PubMed Securin interacts with Cdc20. This interaction was modelled on a demonstrated interaction between human Securin and Xenopus Cdc20. 
    NP_001246.1     BIND  PubMed Bub1/Bub3 complex interacts with Cdc20. 
    Q12834 Q9H1A4 ANAPC1    HPRD  PubMed  
    Q12834 Q9UM13 ANAPC10    HPRD  PubMed  
    Q12834 Q9UJX6 ANAPC2    HPRD  PubMed  
    Q12834 Q9UJX3 ANAPC7    HPRD  PubMed  
    Q12834 O14965 AURKA    HPRD  PubMed  
    Q12834 O43683 BUB1    HPRD  PubMed  
    Q12834 O60566 BUB1B    HPRD  PubMed  
    Q12834 P20248 CCNA2    HPRD  PubMed  
    Q12834 Q13042 CDC16    HPRD  PubMed  
    Q12834 Q12834 CDC20    HPRD  PubMed  
    Q12834 P30260 CDC27    HPRD  PubMed  
    Q12834 Q9UKT4 FBXO5    HPRD  PubMed  
    Q12834 Q13547 HDAC1    HPRD  PubMed  
    Q12834 Q92769 HDAC2    HPRD  PubMed  
    Q12834 Q13257 MAD2L1    HPRD  PubMed  
    Q12834 O95997 PTTG1    HPRD  PubMed  
    Q12834 Q9NS23 RASSF1    HPRD  PubMed  
    Q12834 Q6X4U4 SOSTDC1    HPRD  PubMed  
    Q12834 Spermatogenesis and centriole associated 1 SPATC1    HPRD  PubMed  
    Q12834 P17987 TCP1    HPRD  PubMed  
    Q12834 P36897 TGFBR1    HPRD  PubMed  
    BioGRID:107427 BioGRID:122229 ANAPC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:115665 ANAPC10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:119591 ANAPC11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:118937 ANAPC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:118982 ANAPC4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:119537 ANAPC5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107427 BioGRID:119538 ANAPC7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107427 BioGRID:112666 AURKA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:201352 Anapc1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:213171 Anapc13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:206755 Anapc16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:221196 Anapc2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:208479 Anapc5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:107166 BUB1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:107427 BioGRID:114621 BUB3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:198404 Bub1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:198405 Bub1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:118850 CCDC59    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:114417 CCNA1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107427 BioGRID:107331 CCNA2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107427 BioGRID:107332 CCNB1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107427 BioGRID:114400 CDC16    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107427 BioGRID:107427 CDC20    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:114242 CDC23    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:107431 CDC27    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107427 BioGRID:107426 CDC6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107427 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:107470 CDR2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107427 BioGRID:123555 CDT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107427 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:213776 Cdc16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:223749 Cdc20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:206665 Cdc23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:117655 FBXO5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107427 BioGRID:119967 FBXW5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:119489 FZR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:580243 Gm9174    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:107427 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:107427 BioGRID:109530 HSF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107427 BioGRID:109531 HSF2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107427 BioGRID:115141 IST1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:115984 KDM5B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:110079 KRT31    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:110080 KRT32    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:110081 KRT33A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:110089 KRT85    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:130655 KRTAP19-5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:123810 KRTAP9-2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:123811 KRTAP9-3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:110260 MAD2L1    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107427 BioGRID:115722 MAD2L2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107427 BioGRID:207818 Mad2l1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107427 BioGRID:111310 PIM1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107427 BioGRID:116356 RASSF1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107427 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:131991 SPATC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107427 BioGRID:119148 TAS2R13    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:112938 TK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107427 BioGRID:113123 TTK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107427 BioGRID:116249 UBE2C    BioGRID  PubMed Co-fractionation 
    BioGRID:107427 BioGRID:118150 UBE2S    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107427 BioGRID:119258 YARS2    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • APC/C complex, organism-specific biosystem (from KEGG)
      APC/C complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • APC/C complex, conserved biosystem (from KEGG)
      APC/C complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
    • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
      APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
    • APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystemThe degradation of cyclin B1, which appears to occur at the mitotic spindle, is delayed until the metaphase /anaphase transition by the spindle assembly checkpoint and is required in order for sister...
    • APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystemThe separation of sister chromatids in anaphase requires the destruction of the anaphase inhibitor, securin. Securin associates with and inactivates the protease, separase. Separase cleaves the cohe...
    • APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemFollowing phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the ...
    • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
      APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemFrom late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Gemin...
    • Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemAPC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein ...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystem (from REACTOME)
      Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystemThe activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inactivation of APC/C via direct inhibition of the APC/C complex, organism-specific biosystem (from REACTOME)
      Inactivation of APC/C via direct inhibition of the APC/C complex, organism-specific biosystemIn the direct inhibition model, the cytosolic Mitotic Checkpoint Complex, consisting of hBUBR1, hBUB3, Cdc20 and Mad2, directly inhibits APC/C by binding to it.
    • Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, organism-specific biosystem (from REACTOME)
      Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, organism-specific biosystemThe target of the mitotic checkpoint is the Anaphase Promoting Complex/Cyclosome (APC/C) an E3 ubiquitin ligase that targets proteins whose destruction is essential for mitotic exit. Currently, there...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Mitotic M-M/G1 phases, organism-specific biosystem (from REACTOME)
      Mitotic M-M/G1 phases, organism-specific biosystem
      Mitotic M-M/G1 phases
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and ...
    • Mitotic Spindle Checkpoint, organism-specific biosystem (from REACTOME)
      Mitotic Spindle Checkpoint, organism-specific biosystemThe mitotic checkpoint or spindle assembly checkpoint is an evolutionarily conserved mechanism that ensures that cells with misaligned chromosomes do not exit mitosis and divide to form aneuploid cel...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK1 signaling events, organism-specific biosystem
      PLK1 signaling events
    • Phosphorylation of Emi1, organism-specific biosystem (from REACTOME)
      Phosphorylation of Emi1, organism-specific biosystemThe phosphorylation of Emi1, which is required for its degradation in mitosis, appears to involve both Plk1 and Cdk1.
    • Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
      Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemThe APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zacha...
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle
    • SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystem (from REACTOME)
      SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystemEmi1 destruction in early mitosis requires the SCF�²TrCP ubiquitin ligase complex. Binding of �²TrCP to Emi1 occurs in late prophase and requires phosphorylation at the DSGxxS consensus motif as...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    M phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    activation of anaphase-promoting complex activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		  
    cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle spindle assembly checkpoint TAS
    Traceable Author Statement
    more info
    		  
    mitotic prometaphase TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of synapse maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    regulation of dendrite development IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    spindle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    cell division cycle protein 20 homolog
    Names
    cell division cycle protein 20 homolog
    CDC20 cell division cycle 20 homolog
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001255.2 → NP_001246.2  cell division cycle protein 20 homolog

      Status: REVIEWED

      Source sequence(s)
      BC001088
      Consensus CDS
      CCDS484.1
      UniProtKB/Swiss-Prot
      Q12834
      Related
      ENSP00000308450, OTTHUMP00000008571, ENST00000310955, OTTHUMT00000019487
      Conserved Domains (1) summary
      cd00200
      Location:190 – 471
      Blast Score: 384
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      43824626..43828874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      41944368..41948616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL139289.6 CAB92757.1
    genomic CH471059.2 EAX07101.1
      EAX07102.1
    genomic DQ473545.1 ABE96834.1
    mRNA AF099644.1 AAD16405.1
    mRNA AK225504.1 None
    mRNA AK302539.1 BAG63811.1
    mRNA AK303844.1 BAG64787.1
    mRNA AK312780.1 BAG35643.1
    mRNA BC000624.2 AAH00624.1
    mRNA BC001088.2 AAH01088.1
    mRNA BC006272.2 AAH06272.1
    mRNA BC009425.1 AAH09425.1
    mRNA BC009426.1 AAH09426.1
    mRNA BC010044.2 AAH10044.1
    mRNA BC012803.2 AAH12803.1
    mRNA BC012827.2 AAH12827.1
    mRNA BC013303.2 AAH13303.1
    mRNA BC015998.1 AAH15998.1
    mRNA BC024257.1 AAH24257.1
    mRNA BC031294.1 AAH31294.1
    mRNA BC110321.1 AAI10322.1
    mRNA BT007388.1 AAP36052.1
    mRNA U05340.1 AAA19017.1
    other-genetic DQ892290.2 ABM83216.1
    other-genetic DQ895489.2 ABM86415.1
    other-genetic EU831627.1 ACE87227.1
    other-genetic EU831712.1 ACE86546.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12834.2 GenPept UniProtKB/Swiss-Prot:Q12834
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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