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    G3BP2 GTPase activating protein (SH3 domain) binding protein 2 [ Homo sapiens ]

    Gene ID: 9908, updated on 11-May-2012

    Summary

    Official Symbol
    G3BP2provided by HGNC
    Official Full Name
    GTPase activating protein (SH3 domain) binding protein 2provided by HGNC
    Primary source
    HGNC:30291
    See related
    Ensembl:ENSG00000138757; HPRD:06570; Vega:OTTHUMG00000130097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

    Genomic context

    Location :
    4q21.1
    Sequence :
    Chromosome: 4; NC_000004.11 (76567953..76598667, complement)
    See G3BP2 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene chromosome 4 open reading frame 26 Neighboring gene cyclin-dependent kinase-like 2 (CDC2-related kinase) Neighboring gene USO1 vesicle docking protein homolog (yeast) Neighboring gene protein phosphatase, EF-hand calcium binding domain 2

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UN86 P19838 NFKB1    HPRD  PubMed  
    Q9UN86 P25963 NFKBIA    HPRD  PubMed  
    BioGRID:115237 BioGRID:116170 ASCC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:116429 ATXN2L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:117387 C3orf17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:108027 DDX10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:121353 DDX24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:115909 FARS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:118942 GNL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:119331 ING4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115237 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115237 BioGRID:110859 NFKBIA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115237 BioGRID:121591 NUFIP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:113717 NUP214    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:117165 NUP62    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:111700 PTEN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:111977 RNH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:123917 RPF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:128356 RPL22L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:112043 RPL3L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:114011 STK24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115237 BioGRID:120938 UBAP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:119697 UIMC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:114554 USP10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115237 BioGRID:126399 WDR36    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding NAS
    Non-traceable Author Statement
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    receptor signaling complex scaffold activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    Ras protein signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytoplasmic sequestering of NF-kappaB NAS
    Non-traceable Author Statement
    more info
    PubMed 
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras GTPase-activating protein-binding protein 2
    Names
    ras GTPase-activating protein-binding protein 2
    G3BP-2
    GAP SH3 domain-binding protein 2
    Ras-GTPase activating protein SH3 domain-binding protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012297.4NP_036429.2  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AB014560, AI913597, BM744299, DA094091
      Consensus CDS
      CCDS3571.1
      UniProtKB/Swiss-Prot
      Q9UN86
      Related
      ENSP00000379069, OTTHUMP00000160587, ENST00000395719, OTTHUMT00000252400
      Conserved Domains (2) summary
      cd00780
      Location:7135
      Blast Score: 332
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd00590
      Location:333405
      Blast Score: 153
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
    2. NM_203504.2NP_987100.1  ras GTPase-activating protein-binding protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB014560, AI913597, BC011731, BM744299, DA385285
      Consensus CDS
      CCDS3572.1
      UniProtKB/Swiss-Prot
      Q9UN86
      Related
      ENSP00000350518, OTTHUMP00000160588, ENST00000357854, OTTHUMT00000252401
      Conserved Domains (2) summary
      cd00780
      Location:7135
      Blast Score: 328
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd00590
      Location:300372
      Blast Score: 151
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
    3. NM_203505.2NP_987101.1  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AB014560, AF145284, AI913597, BM744299, DB241424
      Consensus CDS
      CCDS3571.1
      UniProtKB/Swiss-Prot
      Q9UN86
      Related
      ENSP00000352738, OTTHUMP00000160586, ENST00000359707, OTTHUMT00000252399
      Conserved Domains (2) summary
      cd00780
      Location:7135
      Blast Score: 332
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd00590
      Location:333405
      Blast Score: 153
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      76567953..76598667, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      72314522..72345439, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC104828.4 (53890..84529) None
    genomic CH471057.1 EAX05742.1
      EAX05743.1
      EAX05744.1
      EAX05745.1
      EAX05746.1
      EAX05747.1
      EAX05748.1
    mRNA AA781267.1 None
    mRNA AB014560.1 BAA31635.2
    mRNA AF051311.1 AAC15705.1
    mRNA AF053535.1 AAC95292.1
    mRNA AF070615.1 None
    mRNA AF145284.1 AAD51932.1
    mRNA AI913597.1 None
    mRNA AK291772.1 BAF84461.1
    mRNA AK291786.1 BAF84475.1
    mRNA BC011731.2 AAH11731.1
    mRNA BI560692.1 None
    mRNA BM744299.1 None
    mRNA CB996973.1 None
    mRNA CD706717.1 None
    mRNA DA094091.1 None
    mRNA DA385285.1 None
    mRNA DB241424.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UN86.2 GenPept UniProtKB/Swiss-Prot:Q9UN86

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