MRC2 mannose receptor, C type 2 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: MRC2provided by HGNC
Official Full Name: mannose receptor, C type 2provided by HGNC
Primary source: HGNC:16875
See related: Ensembl:ENSG00000011028; HPRD:10094; MIM:612264; Vega:OTTHUMG00000179178
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD280; UPARAP; CLEC13E; ENDO180
Summary: This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]

Genomic context

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Location :: 17q23.2

Sequence :: Chromosome: 17; NC_000017.10 (60704762..60770962)

See MRC2 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

TGFbeta1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis.
Title: TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis.
A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180.
Title: A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180.
Our present study suggests that uPARAP may be involved in glioma cell invasiveness through actin cytoskeletal rearrangement
Title: Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells.
fibrillar collagen deposition and the collagen internalization receptor endo180 have roles in glioma invasion
Title: A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion.
Endo180 is a novel regulator of membrane-bound matrix metalloproteinase (MT1-MMP) activity, MT1-MMP-dependent MMP-2 activation and urokinase plasminogen activator (uPA) activity.
Title: Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180.
Observational study of gene-disease association. (HuGE Navigator)
Title: Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants.
To investigate the consequence of Endo180 up-regulation, MCF7 cells transfected with Endo180 were inoculated into immunocompromised mice; expression of wild-type Endo180, but not an internalization-defective Endo180 mutant, showed enhanced tumor growth.
Title: The collagen receptor Endo180 (CD280) Is expressed on basal-like breast tumor cells and promotes tumor growth in vivo.
Endo180 plays a physiological role in mediating collagen matrix remodelling during tissue development and homeostasis
Title: Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor.
Data suggest that uPARAP/Endo180 participates in the connective tissue destruction during head and neck squamous cell carcinoma progression by mediating cellular uptake and lysosomal degradation of collagen.
Title: Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer.
Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor
Title: Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor.

Submit: New GeneRIF Correction See all (16)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 binds to mannose receptor on vaginal epithelial cells	PubMed
	env	Mannose receptor (MR) dimers bind to soluble monomeric and trimeric HIV envelope and to HIV virion in capture assay	PubMed
	env	HIV-1 gp120 binds to B cells through mannose C-type lectin receptors (MCLRs), such as DC-SIGN, mannose receptor, and langerin	PubMed
	env	Recombinant HIV-1 gp120 blocks Mannose Receptor-mediated phagocytosis in human and murine macrophages and microglial cells	PubMed
	env	HIV-1 gp120 interaction with human mannose receptor (hMR) results in increased production of matrix metalloproteinase-2 (MMP-2) in astrocytes	PubMed
Tat, p14	tat	HIV-1 Tat represses transcription from the rat mannose receptor promoter, thereby downregulating expression of mannose receptor	PubMed
	tat	HIV-1 Tat interaction with cyclin T1 is required for the repression of mannose receptor (MR) and bone morphogenetic protein receptor-2 (BMPR2) promoters	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:115231	BioGRID:123527	NDEL1		BioGRID	PubMed	Two-hybrid
BioGRID:115231	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
Antigen processing-Cross presentation, organism-specific biosystem (from REACTOME)
Antigen processing-Cross presentation, organism-specific biosystemMHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment ...
Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
Cross-presentation of soluble exogenous antigens (endosomes), organism-specific biosystem (from REACTOME)
Cross-presentation of soluble exogenous antigens (endosomes), organism-specific biosystemExogenous soluble antigens are cross-presented by dendritic cells, albeit with lower efficiency than for particulate substrates. Soluble antigens destined for cross-presentation are taken up by disti...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Phagosome, organism-specific biosystem (from KEGG)
Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Phagosome, conserved biosystem (from KEGG)
Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

General gene information

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Markers

RH80967 (e-PCR)
- UniSTS:91252

RH12891 (e-PCR)
- UniSTS:69023

MRC2_7204 (e-PCR)
- UniSTS:466340

MARC_26180-26181:1030714398:1 (e-PCR)
- UniSTS:268973

D17S1283 (e-PCR)
- UniSTS:18605

RH47836 (e-PCR)
- UniSTS:19895

Homology

Homologs of the MRC2 gene: The MRC2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
carbohydrate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
endocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
integral to membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-type mannose receptor 2

Names: C-type mannose receptor 2; endocytic receptor 180; UPAR-associated protein; macrophage mannose receptor 2; C-type lectin domain family 13 member E; endocytic receptor (macrophage mannose receptor family); urokinase-type plasminogen activator receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006039.4 → NP_006030.2 C-type mannose receptor 2 precursor

Status: REVIEWED

Source sequence(s)

AI458446, BC032763, BC146647, BC153884

Consensus CDS

CCDS11634.1

UniProtKB/Swiss-Prot

Q9UBG0

Related

ENSP00000307513, OTTHUMP00000260853, ENST00000303375, OTTHUMT00000445152

Conserved Domains (5) summary

cd00062
Location:181 – 228
Blast Score: 196

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cd00161
Location:43 – 127
Blast Score: 102

RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

cd00037
Location:247 – 361
Blast Score: 299

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd03590
Location:382 – 506
Blast Score: 314

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

smart00458
Location:46 – 161
Blast Score: 178

RICIN; Ricin-type beta-trefoil

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p10 Primary Assembly

Range

60704762..60770962

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

56071831..56137989

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018928.1 Alternate CHM1_1.0

Range

61721593..61787785

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01035342.1 (27897..38247)	None
genomic	ABBA01035343.1	None
genomic	AC080038.5 (24549..89450)	None
genomic	AMYH01008547.1 (148122..214314)	None
genomic	CH471109.2	EAW94341.1
		EAW94342.1
mRNA	AB014609.2	BAA31684.2
mRNA	AF107292.1	AAF14192.1
mRNA	AF134838.1	AAD30280.1
mRNA	AI458446.1	None
mRNA	AK093230.1	BAG52674.1
mRNA	AY429551.1	None
mRNA	BC032763.1	None
mRNA	BC146647.1	AAI46648.1
mRNA	BC150212.1	AAI50213.1
mRNA	BC153884.1	AAI53885.1
mRNA	BX111813.1	None
mRNA	U58856.1	AAC51365.1