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SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 [ Homo sapiens (human) ]

Gene ID: 9901, updated on 12-May-2016
Official Symbol
SRGAP3provided by HGNC
Official Full Name
SLIT-ROBO Rho GTPase activating protein 3provided by HGNC
Primary source
HGNC:HGNC:19744
See related
Ensembl:ENSG00000196220 HPRD:12108; MIM:606525; Vega:OTTHUMG00000090589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WRP; MEGAP; SRGAP2; ARHGAP14
Orthologs
Location:
3p25.3
Exon count:
32
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (8980591..9362929, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9022275..9291369, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene oxytocin receptor Neighboring gene RAD18, E3 ubiquitin protein ligase Neighboring gene uncharacterized LOC101927416 Neighboring gene SRGAP3 antisense RNA 3 Neighboring gene uncharacterized LOC101927440 Neighboring gene THUMPD3 antisense RNA 1 Neighboring gene phosphoglycerate mutase 1 pseudogene 4 Neighboring gene THUMP domain containing 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Inactivation of Cdc42 and Rac, organism-specific biosystem (from REACTOME)
    Inactivation of Cdc42 and Rac, organism-specific biosystemRho family GTPases including Rac, Rho, and Cdc42 are ideal candidates to regulate aspects of cytoskeletal dynamics downstream of axon guidance receptors. Biochemical and genetic studies have revealed...
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
    Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0411

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
GTPase activator activity TAS
Traceable Author Statement
more info
 
Rac GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
SLIT-ROBO Rho GTPase-activating protein 3
Names
SLIT-ROBO Rho GTPase activating protein 2
WAVE-associated Rac GTPase activating protein
mental disorder-associated GAP
rho GTPase-activating protein 14

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033117.2NP_001028289.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform b

    See identical proteins and their annotated locations for NP_001028289.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AF464189, AK054831, BM976179, DA532895
    Consensus CDS
    CCDS33689.1
    UniProtKB/Swiss-Prot
    O43295
    Related
    ENSP00000353587, OTTHUMP00000207115, ENST00000360413, OTTHUMT00000338052
    Conserved Domains (4) summary
    cd07684
    Location:26278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:724776
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:481665
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:350400
    Flg_hook; Flagellar hook-length control protein FliK
  2. NM_014850.3NP_055665.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform a

    See identical proteins and their annotated locations for NP_055665.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF427144, AK054831, BM976179, DA532895
    Consensus CDS
    CCDS2572.1
    UniProtKB/Swiss-Prot
    O43295
    Related
    ENSP00000373347, OTTHUMP00000115707, ENST00000383836, OTTHUMT00000207137
    Conserved Domains (4) summary
    cd07684
    Location:26278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:748800
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:502689
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:350400
    Flg_hook; Flagellar hook-length control protein FliK

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    8980591..9362929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534298.1XP_011532600.1  

    See identical proteins and their annotated locations for XP_011532600.1

    Conserved Domains (4) summary
    cd11955
    Location:604656
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:361545
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:230280
    Flg_hook; Flagellar hook-length control protein FliK
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_011534297.1XP_011532599.1  

    See identical proteins and their annotated locations for XP_011532599.1

    Conserved Domains (4) summary
    cd11955
    Location:604656
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:361545
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:230280
    Flg_hook; Flagellar hook-length control protein FliK
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. XM_011534299.1XP_011532601.1  

    See identical proteins and their annotated locations for XP_011532601.1

    Conserved Domains (4) summary
    cd11955
    Location:604656
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:361545
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:230280
    Flg_hook; Flagellar hook-length control protein FliK
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. XM_011534295.1XP_011532597.1  

    See identical proteins and their annotated locations for XP_011532597.1

    Conserved Domains (4) summary
    cd07684
    Location:26278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:753805
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:510694
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:350400
    Flg_hook; Flagellar hook-length control protein FliK
  5. XM_011534296.1XP_011532598.1  

    Conserved Domains (4) summary
    cd07684
    Location:7259
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:734786
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:491675
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:331381
    Flg_hook; Flagellar hook-length control protein FliK
  6. XM_011534300.1XP_011532602.1  

    See identical proteins and their annotated locations for XP_011532602.1

    Conserved Domains (4) summary
    cd11955
    Location:604656
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:361545
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:230280
    Flg_hook; Flagellar hook-length control protein FliK
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  7. XM_011534303.1XP_011532605.1  

    Conserved Domains (2) summary
    cd11955
    Location:240292
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:5181
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
  8. XM_011534301.1XP_011532603.1  

    Conserved Domains (4) summary
    cd11955
    Location:590642
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:347531
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:187237
    Flg_hook; Flagellar hook-length control protein FliK
    cl12013
    Location:1115
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  9. XM_011534302.1XP_011532604.1  

    Conserved Domains (4) summary
    cd07684
    Location:26278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:753805
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:510694
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:350400
    Flg_hook; Flagellar hook-length control protein FliK

RNA

  1. XR_427300.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    8972526..9241578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033116.1: Suppressed sequence

    Description
    NM_001033116.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.