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    CDC6 cell division cycle 6 homolog (S. cerevisiae) [ Homo sapiens ]

    Gene ID: 990, updated on 19-Feb-2012
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    Summary

    Official Symbol
    CDC6provided by HGNC
    Official Full Name
    cell division cycle 6 homolog (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:1744
    See related
    Ensembl:ENSG00000094804; HPRD:04022; MIM:602627; Vega:OTTHUMG00000133324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC18L; HsCDC6; HsCDC18
    Summary
    The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    17q21.3
    Sequence :
    Chromosome: 17; NC_000017.10 (38444146..38459413)
    See CDC6 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF)-like 1 Neighboring gene WAS/WASL interacting protein family, member 2 Neighboring gene RNA, Ro-associated Y4 pseudogene 8 Neighboring gene retinoic acid receptor, alpha Neighboring gene uncharacterized LOC100287525 Neighboring gene gap junction protein, delta 3, 31.9kDa

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins. Sideridou M, et al. J Cell Biol, 2011 Dec 26. PMID 22201124.
    2. Interactions of MCP1 with components of the replication machinery in mammalian cells. Bronze-da-Rocha E, et al. Int J Biol Sci, 2011 Feb 17. PMID 21383955.
    3. Mutations in the pre-replication complex cause Meier-Gorlin syndrome. Bicknell LS, et al. Nat Genet, 2011 Feb 27. PMID 21358632.
    4. Activation of Cdk2/Cyclin E complexes is dependent on the origin of replication licensing factor Cdc6 in mammalian cells. Lunn CL, et al. Cell Cycle, 2010 Nov 15. PMID 21088490.
    5. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. Casabonne D, et al. Haematologica, 2011 Feb. PMID 21048031.

    See all (84) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The Cdc6 acts as a molecular switch at the E-cadherin locus, linking transcriptional repression to activation of replication.
      Title: Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins.
    2. Cdc6 expression is required for CDK2 chromatin association and kinase activation in stimulated primary human fibroblasts.
      Title: Activation of Cdk2/Cyclin E complexes is dependent on the origin of replication licensing factor Cdc6 in mammalian cells.
    3. Plk1-mediated phosphorylation of Cdc6 promotes the interaction of Cdc6 and Cdk1, leading to the attenuation of Cdk1 activity, release of separase, and subsequent anaphase progression.
      Title: Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase.
    4. The CDC6 G1321A polymorphism may contribute to the risk of cervical cancer.
      Title: Association between the CDC6 G1321A polymorphism and the risk of cervical cancer.
    5. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
    6. The expression of CDC6 was positively correlated with hMSH2 in cervical cancer.
      Title: [Expression and clinical significance of CDC6 and hMSH2 in cervical carcinoma].
    7. Human CDC6 physically interacts with ATR, a crucial checkpoint kinase, in a manner that is stimulated by phosphorylation by Cdk and the CDC6-ATR interaction is conserved in Xenopus.
      Title: CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.
    8. The Cdc6 protein, a key DNA replication initiation factor, contributes to the long-term maintenance of the S-phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin.
      Title: ATR (AT mutated Rad3 related) activity stabilizes Cdc6 and delays G2/M-phase entry during hydroxyurea-induced S-phase arrest of HeLa cells.
    9. peak androgen receptor occupancy at the novel androgen-response element occurs during the G1/S phase concomitant with peak Cdc6 mRNA expression.
      Title: A novel androgen receptor-binding element modulates Cdc6 transcription in prostate cancer cells during cell-cycle progression.
    10. The combination of st and deregulated cyclin E result in cooperative and coordinated activation of both an essential origin licensing factor, CDC6, and an activity required for origin firing, CDK2, resulting in progression from quiescence to S phase.
      Title: Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E.
    Submit: New GeneRIF Correction See all (40)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    MEIER-GORLIN SYNDROME 5

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000017.9 NP_005216.1 E2F1    BIND  PubMed E2F1 interacts with the Cdc6 promoter region. 
    NC_000017.9 NP_004082.1 E2F2    BIND  PubMed E2F2 interacts with the Cdc6 promoter region. 
    NC_000017.9 NP_001940.1 E2F3    BIND  PubMed E2F3 interacts with the Cdc6 promoter. 
    NC_000017.9 NP_001941.2 E2F4    BIND  PubMed E2F4 interacts with the Cdc6 promoter region. 
    NC_000017.9 NP_005602.2 RBL2    BIND  PubMed RBL2 (p130) interacts with the CDC6 promoter. 
    NC_000017.9 NP_005602.2 RBL2    BIND  PubMed p130 interacts with the Cdc6 promoter region. 
    NP_001245.1 MCM8    BIND  PubMed MCM8 interacts with cdc6. 
    NP_001245.1     BIND  PubMed The Cyclin A-Cdk2 complex phosphorylates HsCdc6 
    NP_001245.1     BIND  PubMed The Cyclin E-Cdk2 complex phosphorylates HsCdc6 
    Q99741 Q9ULX6 AKAP8L    HPRD  PubMed  
    Q99741 P20248 CCNA2    HPRD  PubMed  
    Q99741 P24941 CDK2    HPRD  PubMed  
    Q99741 P38936 CDKN1A    HPRD  PubMed  
    Q99741 Q8N726 CDKN2A    HPRD  PubMed  
    Q99741 Q9H211 CDT1    HPRD  PubMed  
    Q99741 Q7L590 MCM10    HPRD  PubMed  
    Q99741 P49736 MCM2    HPRD  PubMed  
    Q99741 P25205 MCM3    HPRD  PubMed  
    Q99741 P33993 MCM7    HPRD  PubMed  
    Q99741 P01106 MYC    HPRD  PubMed  
    Q99741 Q13415 ORC1    HPRD  PubMed  
    Q99741 Q13416 ORC2    HPRD  PubMed  
    Q99741 Q9UBD5 ORC3    HPRD  PubMed  
    Q99741 O43913 ORC5    HPRD  PubMed  
    Q99741 Q9Y5N6 ORC6    HPRD  PubMed  
    Q99741 P12004 PCNA    HPRD  PubMed  
    Q99741 Q06190 PPP2R3A    HPRD  PubMed  
    Q99741 Q9Y5P8 PPP2R3B    HPRD  PubMed  
    Q99741 P11801 PSKH1    HPRD  PubMed  
    Q99741 P62979 RPS27A    HPRD  PubMed  
    BioGRID:107426 BioGRID:117940 AKAP8L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107426 BioGRID:106962 ATM    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107426 BioGRID:107027 ATR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107426 BioGRID:313463 ATRIP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107426 BioGRID:107116 BMI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107426 BioGRID:112251 CCL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107426 BioGRID:107331 CCNA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107426 BioGRID:107427 CDC20    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107426 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107426 BioGRID:123555 CDT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107426 BioGRID:204750 Cdc6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107426 BioGRID:119489 FZR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107426 BioGRID:115385 HUWE1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107426 BioGRID:116315 KAT7    BioGRID  PubMed Biochemical Activity 
    BioGRID:107426 BioGRID:110340 MCM3    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:107426 BioGRID:110344 MCM7    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107426 BioGRID:124109 MCM8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107426 BioGRID:110694 MYC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107426 BioGRID:111040 ORC1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid 
    BioGRID:107426 BioGRID:111041 ORC2    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Two-hybrid 
    BioGRID:107426 BioGRID:111142 PCNA    BioGRID  PubMed Two-hybrid 
    BioGRID:107426 BioGRID:111515 PPP2R3A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107426 BioGRID:118179 PPP2R3B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107426 BioGRID:111654 PSKH1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107426 BioGRID:112872 TERF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107426 BioGRID:113162 UBB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107426 BioGRID:99532 atr    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the CDC6 gene: The CDC6 gene is conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, M.grisea, and N.crassa.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Activation of ATR in response to replication stress, organism-specific biosystem (from REACTOME)
      Activation of ATR in response to replication stress, organism-specific biosystemGenotoxic stress caused by DNA damage or stalled replication forks can lead to genomic instability. To guard against such instability, genotoxically-stressed cells activate checkpoint factors that ha...
    • Activation of the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Activation of the pre-replicative complex, organism-specific biosystemIn S. cerevisiae, two ORC subunits, Orc1 and Orc5, both bind ATP, and Orc1 in addition has ATPase activity. Both ATP binding and ATP hydrolysis appear to be essential functions in vivo. ATP binding b...
    • Assembly of the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Assembly of the pre-replicative complex, organism-specific biosystemDNA replication pre-initiation in eukaryotic cells begins with the formation of the pre-replicative complex (pre-RC) during the late M phase and continues in the G1 phase of the mitotic cell cycle, a...
    • Association of licensing factors with the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Association of licensing factors with the pre-replicative complex, organism-specific biosystemThe eukaryotic six-subunit origin recognition complex (ORC) governs the initiation site of DNA replication and formation of the prereplication complex.
    • CDC6 association with the ORC:origin complex, organism-specific biosystem (from REACTOME)
      CDC6 association with the ORC:origin complex, organism-specific biosystemCdc6 is a regulator of DNA replication initiation in both yeasts and human cells, but its mechanism of action differs between the two systems. Genetic studies in budding yeast (S. cerevisiae) and fis...
    • CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystem (from REACTOME)
      CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystemAs cells enter S phase, HsCdc6p is phosphorylated by CDK promoting its export from the nucleus (see Bell and Dutta 2002).
    • CDT1 association with the CDC6:ORC:origin complex, organism-specific biosystem (from REACTOME)
      CDT1 association with the CDC6:ORC:origin complex, organism-specific biosystemInitiation protein Cdt1 was first identified in X. laevis, where it has been shown to be the second component of licensing factor (RLF-B) and in S. pombe. Cdt1 homologs have been identified in D. mel...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • DNA Replication, organism-specific biosystem (from WikiPathways)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA Replication Pre-Initiation, organism-specific biosystem (from REACTOME)
      DNA Replication Pre-Initiation, organism-specific biosystemAlthough, DNA replication occurs in the S phase of the cell cycle, the formation of the DNA replication pre-initiation complex begins during G1 phase.
    • E2F mediated regulation of DNA replication, organism-specific biosystem (from REACTOME)
      E2F mediated regulation of DNA replication, organism-specific biosystemProgression through G1 and G1 to S-phase transition that initiates DNA synthesis involve many complexes that are regulated by Rb:E2F pathway. Rb:E2F pathway plays a key role in gene expression regul...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • G0 and Early G1, organism-specific biosystem (from REACTOME)
      G0 and Early G1, organism-specific biosystemIn G0 and early G1 in quiescent cells, p130 (RBL2) bound to E2F4 or E2F5 and either DP1 or DP2, associates with the MuvB complex, forming an evolutionarily conserved DREAM complex, that represses tr...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • G1/S-Specific Transcription, organism-specific biosystem (from REACTOME)
      G1/S-Specific Transcription, organism-specific biosystemThe E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle. E2F activity is regulated by members of the retinoblastoma protein (pRb) family, resulti...
    • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
      G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
    • M/G1 Transition, organism-specific biosystem (from REACTOME)
      M/G1 Transition, organism-specific biosystemFinally, progression out of mitosis and division of the cell into two daughters (cytokinesis) requires the inactivation of Cyclin B - Cdc2 by ubiquitin-dependent proteolysis of Cyclin A and B, which ...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Mitotic M-M/G1 phases, organism-specific biosystem (from REACTOME)
      Mitotic M-M/G1 phases, organism-specific biosystem
      Mitotic M-M/G1 phases
    • Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
      Orc1 removal from chromatin, organism-specific biosystem
      Orc1 removal from chromatin
    • Regulation of DNA replication, organism-specific biosystem (from REACTOME)
      Regulation of DNA replication, organism-specific biosystemDNA replication is regulated at various levels via ORC proteins. This pathway includes annotation of individual events that lead to the regulation of replication.
    • Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
      Removal of licensing factors from origins, organism-specific biosystemLicensing factors are removed from the origin by various means like biochemical modification (phosphorylation) or by physical association with other proteins. This pathway includes the annotations of...
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continu...
    • Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
      Switching of origins to a post-replicative state, organism-specific biosystem
      Switching of origins to a post-replicative state
    • Synthesis of DNA, organism-specific biosystem (from REACTOME)
      Synthesis of DNA, organism-specific biosystemThe actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    		  
    nucleoside-triphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    DNA replication TAS
    Traceable Author Statement
    more info
    		  
    DNA replication checkpoint TAS
    Traceable Author Statement
    more info
    		 PubMed 
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    M/G1 transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of cell cycle cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of chromosome segregation IDA
    Inferred from Direct Assay
    more info
    		  
    regulation of cyclin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of mitotic anaphase IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of transcription involved in G1/S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    traversing start control point of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    spindle midzone IDA
    Inferred from Direct Assay
    more info
    		  
    spindle pole IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    cell division control protein 6 homolog
    Names
    cell division control protein 6 homolog
    p62(cdc6)
    CDC6-related protein
    cdc18-related protein
    CDC6 cell division cycle 6 homolog
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028240.1 RefSeqGene

      Range
      5001..20268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001254.3 → NP_001245.1  cell division control protein 6 homolog

      Status: REVIEWED

      Source sequence(s)
      AA210818, BC025232, BE296640, BE548194, BF203219, U77949
      Consensus CDS
      CCDS11365.1
      UniProtKB/Swiss-Prot
      Q99741
      Related
      ENSP00000209728, OTTHUMP00000164449, ENST00000209728, OTTHUMT00000257129
      Conserved Domains (3) summary
      cd00009
      Location:178 – 330
      Blast Score: 141
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      TIGR02928
      Location:168 – 516
      Blast Score: 380
      TIGR02928; orc1/cdc6 family replication initiation protein
      cd08768
      Location:458 – 528
      Blast Score: 164
      Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding.

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      38444146..38459413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      34237430..34252580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB010492.1 None
    genomic AC080112.15 (120537..135804) None
    genomic AJ009560.1 None
    genomic AY150310.1 AAN10296.1
    genomic CH471152.1 EAW60650.1
      EAW60651.1
    genomic CQ789346.1 CAG24445.1
    mRNA AA210818.1 None
    mRNA AF022109.1 AAC52071.1
    mRNA AK313620.1 BAG36382.1
    mRNA BC025232.1 AAH25232.1
    mRNA BE296640.1 None
    mRNA BE548194.1 None
    mRNA BF203219.1 None
    mRNA U77949.1 AAB38317.1
    other-genetic DQ892840.2 ABM83766.1
    other-genetic DQ896087.2 ABM87086.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q99741.1 GenPept UniProtKB/Swiss-Prot:Q99741
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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