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    PJA2 praja ring finger 2, E3 ubiquitin protein ligase [ Homo sapiens (human) ]

    Gene ID: 9867, updated on 5-May-2013
    Official Symbol
    PJA2provided by HGNC
    Official Full Name
    praja ring finger 2, E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:17481
    See related
    Ensembl:ENSG00000198961; HPRD:11436; Vega:OTTHUMG00000128750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF131; Neurodap1
    Location :
    5q21.3
    Sequence :
    Chromosome: 5; NC_000005.9 (108670410..108745675, complement)
    See PJA2 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene fer (fps/fes related) tyrosine kinase Neighboring gene LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) pseudogene Neighboring gene gap junction protein, alpha 1, 43kDa pseudogene 1 Neighboring gene keratin 18 pseudogene 42 Neighboring gene mannosidase, alpha, class 2A, member 1 Neighboring gene cancer/testis antigen family 45, member B1 pseudogene

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    2. Expression of the ring ligase PRAJA2 in thyroid cancer. Cantara S, et al. J Clin Endocrinol Metab, 2012 Nov. PMID 22948757.
    3. CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly. Gomez-Ferreria MA, et al. Cell Cycle, 2012 Oct 1. PMID 22895009.
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, et al. Mol Cell Proteomics, 2012 May. PMID 22505724.
    5. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.

    See all (28) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. praja2 is a novel cancer-related gene whose expression is linked to the histotype and mutational status of the thyroid tumor.
      Title: Expression of the ring ligase PRAJA2 in thyroid cancer.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    O43164 Q9Y5V3 MAGED1    HPRD  PubMed  
    O43164 P62837 UBE2D2    HPRD  PubMed  
    BioGRID:115200 BioGRID:120432 CEP192    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115200 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115200 BioGRID:108309 ELAVL1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:115200 BioGRID:116298 FAF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115200 BioGRID:116806 FAF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115200 BioGRID:114879 MAGED1    BioGRID  PubMed Two-hybrid 
    BioGRID:115200 BioGRID:111559 PRKAR1A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115200 BioGRID:111562 PRKAR2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115200 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:115200 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:115200 BioGRID:113170 UBE2D2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115200 BioGRID:113171 UBE2D3    BioGRID  PubMed Two-hybrid 
    BioGRID:115200 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:115200 BioGRID:119555 UBE2J1    BioGRID  PubMed Two-hybrid 
    BioGRID:115200 BioGRID:114672 UBE2L6    BioGRID  PubMed Two-hybrid 
    BioGRID:115200 BioGRID:113182 UBE2N    BioGRID  PubMed Two-hybrid 
    BioGRID:115200 BioGRID:120572 UBE2W    BioGRID  PubMed Two-hybrid 
    BioGRID:115200 BioGRID:119239 UBXN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115200 BioGRID:117507 UBXN7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115200 BioGRID:122327 USP46    BioGRID  PubMed Affinity Capture-MS 
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

    Markers

    Genotypes

    Homology

    Clone Names

    • KIAA0438

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein kinase A catalytic subunit binding IMP
    Inferred from Mutant Phenotype
    more info
    		  
    protein kinase A regulatory subunit binding IMP
    Inferred from Mutant Phenotype
    more info
    		  
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    long-term memory ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		  
    regulation of protein kinase A signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    E3 ubiquitin-protein ligase Praja-2
    Names
    E3 ubiquitin-protein ligase Praja-2
    praja2
    ring finger protein 131
    praja 2, RING-H2 motif containing
    NP_055634.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014819.4 → NP_055634.3  E3 ubiquitin-protein ligase Praja-2

      Status: VALIDATED

      Source sequence(s)
      AB007898, BM469517, BM681899, BP301854, BQ228553
      Consensus CDS
      CCDS4099.1
      UniProtKB/Swiss-Prot
      O43164
      Related
      ENSP00000354775, OTTHUMP00000158944, ENST00000361189, OTTHUMT00000250663
      Conserved Domains (2) summary
      cd00162
      Location:633 – 678
      Blast Score: 135
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13923
      Location:630 – 676
      Blast Score: 143
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p10 Primary Assembly

      Range
      108670410..108745675, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      103843957..103918776, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018916.1 Alternate CHM1_1.0

      Range
      108952134..109026749, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01069090.1 (160024..201020) None
    genomic ABBA01069091.1 None
    genomic ABBA01069092.1 None
    genomic AC008467.7 (100915..106729) None
    genomic AC010625.6 (81965..124951) None
    genomic AMYH01015542.1 (70159..76084) None
    genomic AMYH01015543.1 None
    genomic AMYH01015544.1 None
    genomic AMYH01015545.1 None
    genomic CH471086.2 EAW49050.1
      EAW49051.1
    mRNA AB007898.1 BAA23710.2
    mRNA AK291759.1 BAF84448.1
    mRNA BC030826.1 AAH30826.1
    mRNA BM469517.1 None
    mRNA BM681899.1 None
    mRNA BP301854.1 None
    mRNA BQ228553.1 None
    mRNA CR749579.1 CAH18371.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43164.4 GenPept UniProtKB/Swiss-Prot:O43164

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

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      • Order cDNA clone
        Order cDNA clone
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      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
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        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
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        Link to related Nucleotide entry
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        Related Probe entry
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        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
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        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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