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RUSC2 RUN and SH3 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 9853, updated on 26-May-2016
Official Symbol
RUSC2provided by HGNC
Official Full Name
RUN and SH3 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:23625
See related
Ensembl:ENSG00000198853 HPRD:18009; MIM:611053; Vega:OTTHUMG00000019861
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Iporin
Summary
This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2012]
Orthologs
Location:
9p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (35489838..35561898)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35490007..35561895)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene unc-13 homolog B (C. elegans) Neighboring gene ATPase phospholipid transporting 8B5, pseudogene Neighboring gene zinc finger AN1-type containing 6 pseudogene 1 Neighboring gene uncharacterized LOC105376026 Neighboring gene ribosomal protein L36a pseudogene 33 Neighboring gene family with sequence similarity 166 member B Neighboring gene ribosomal protein S29 pseudogene 17 Neighboring gene microRNA 4667 Neighboring gene testis-specific kinase 1

Replication interactions

Interaction Pubs
Knockdown of RUN and SH3 domain containing 2 (RUSC2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ60109, KIAA0375

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
iporin
Names
RUN and SH3 domain-containing protein 2
interacting protein of Rab1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135999.1NP_001129471.1  iporin

    See identical proteins and their annotated locations for NP_001129471.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI818507, AL133476, BC146654, DA185385
    Consensus CDS
    CCDS35008.1
    UniProtKB/Swiss-Prot
    Q8N2Y8
    Related
    ENSP00000393922, ENST00000455600
    Conserved Domains (2) summary
    pfam02759
    Location:10391149
    RUN; RUN domain
    cl17036
    Location:14511501
    SH3; Src Homology 3 domain superfamily
  2. NM_014806.3NP_055621.1  iporin

    See identical proteins and their annotated locations for NP_055621.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and thus differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI818507, BC150262, DB460837
    Consensus CDS
    CCDS35008.1
    UniProtKB/Swiss-Prot
    Q8N2Y8
    Related
    ENSP00000355177, OTTHUMP00000021331, ENST00000361226, OTTHUMT00000052309
    Conserved Domains (2) summary
    pfam02759
    Location:10391149
    RUN; RUN domain
    cl17036
    Location:14511501
    SH3; Src Homology 3 domain superfamily

RNA

  1. NR_052015.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI818507, BC150211, DB460837

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    35489838..35561898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716896.1XP_006716959.1  

    Conserved Domains (2) summary
    cd11957
    Location:573623
    SH3_RUSC2; Src homology 3 domain of RUN and SH3 domain-containing protein 2
    pfam02759
    Location:161271
    RUN; RUN domain

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    35489725..35561683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)